Arachidonic acid release and platelet-activating factor formation by staurosporine in human neutrophils challenged with n-formyl peptide

European Journal of Pharmacology

Volumn 218, Issue 2-3, 1992, Pages 251-258

  Müller, Stefan ^a   Nigam, Santosh ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Arachidonic acid; Neutrophils; PAF (platelet activating factor, PAF acether); Phospholipase A2; Staurosporine

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 1 O ALKYLGLYCERO 3 PHOSPHORYLCHOLINE; ACETYL COENZYME A ACETYLTRANSFERASE; ARACHIDONIC ACID; FORMYLMETHIONYLLEUCYLPHENYLALANINE; LEUKOTRIENE B4; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE A2; PROTEIN KINASE INHIBITOR; RADIOISOTOPE; SEROTONIN; SPHINGOSINE; STAUROSPORINE; SUPEROXIDE; THROMBOCYTE ACTIVATING FACTOR;

ARACHIDONIC ACID METABOLISM; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL;

ALKALOIDS; ARACHIDONIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMAN; IN VITRO; LEUKOTRIENE B4; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PHOSPHOLIPASES A; PLATELET ACTIVATING FACTOR; PROTEIN KINASE C; STAUROSPORINE; SUPPORT, NON-U.S. GOV'T;

EID: 0026773947     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(92)90176-5     Document Type: Article

References (36)

1. Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers
2. Staurosporine inhibits the soluble and membrane bound tyrosine kinases of human neutrophil
3. Inositol triphosphate and diacylglycerol: two interacting second messengers
4. A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
5. Metabolism of arachidonic acid in polymorphonuclear leukocytes. Effects of the ionosphere A23187
6. 1-Ether-linked phosphoglycerides. Major sources of arachidonate in the human neutrophil
7. Staurosporine, a protein kinase inhibitor, up-regulates the stimulation of human neutrophil respiratory burst by n-formyl peptides and platelet-activating factor
8. Inhibition of protein kinase C by H-7 potentiates the release of oleic, linoleic and arachidonic acids in A23187-stimulated human neutrophils
9. 2 in human neutrophils
10. Staurosporine inhibits the respiratory burst and induces exocytosis in human neutrophils
11. K252a is a potent and selective inhibitor of phosphorylase kinase
12. Effect of protein kinase C inhibitors on calcium ionophore-induced arachidonic acid mobilization in human leukocytes
13. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets
14. Protein phosphorylation associated with the stimulation of neutrophils. Modulation of superoxide production by protein kinase C and calcium
15. Isoqinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C
16. Mechanism of N-formyl-methionyl-leucyl-phenylalanine- and platelet-activating factor-induced arachidonic acid release in guinea pig alveolar macrophages: Involvement of a GTP-binding protein and role of protein kinase A and protein kinase C
17. Arachidonate release in neutrophils: does a lack of effect of protein kinase C inhibitors imply no involvement of protein kinase C?
18. Function, metabolism and regulation of platelet-activating factor and related ether lipids
19. Biosynthesis of paf-acether. X. Phorbol myristate acetate-induced paf-acether biosynthesis and acetyltransferase activation in human neutrophils
20. Phorbol myristate acetate and the calcium ionophore A23187 synergistically induce release of LTB4 by human neutrophils: involvement of protein kinase C activation in regulation of the 5-lipoxygenase pathway
21. Protein kinase C isotypes and signaling in neutrophils
22. 4 by human neutrophils
23. 14C-serotonin release assay for platelet-activiting factor (PAF) in human neutrophils
24. Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action
25. Modulation of acetyl-CoA: 1-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PAF) acetyltransferase in human polymorphonuclears. The role of cyclic AMP-dependent and phospholipid sensitive, calcium-dependent protein kinases
26. Extraction of eicosanoids from biological samples
27. Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in culture using an automatic enzyme immunoassay reader
28. Utility of staurosporine in uncovering differences in the signal transduction pathways for superoxide production in neutrophils
29. Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases
30. Modulation of PAF biosynthesis in human polymorphonuclear leukocyte. The role of phorbol esters and protein kinases
31. 2+ dependent protein kinase
32. Arachidonic acid release in rabbit neutrophils
33. Phorbol-12-myristate, 13-acetate potentiates the action of the calcium ionophore in stimulating arachidonic acid release and production of phosphatidic acid in rabbit neutrophils
34. Release and metabolism of arachidonic acid in human neutrophils
35. The protein kinase inhibitor staurosporine, like phorbolesters, induces the association of protein kinase C with membranes
36. 2+/calmodulin-dependent protein kinase II