Targeting antiretroviral nucleoside analogues in phosphorylated form to macrophages: In vitro and in vivo studies

Proceedings of the National Academy of Sciences of the United States of America

Volumn 89, Issue 14, 1992, Pages 6477-6481

  Magnani, Mauro ^a   Rossi, Luigia ^a   Brandi, Giorgio ^a   Schiavano, Giuditta F ^a   Montroni, Maria ^b   Piedimonte, Giuseppe ^c  

^a UNIVERSITY OF URBINO   (Italy)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^c UNIVERSITY OF PARMA   (Italy)

Author keywords

2 ,3 dideoxycytidine 5 triphosphate; Erythrocytes; Human immunodeficiency virus inhibition; Murine acquired immunodeficiency syndrome

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MURINAE; ANIMALIA;

2',3' DIDEHYDRO 2',3' DIDEOXYCYTIDINE; AUTOANTIGEN; IMMUNOGLOBULIN G; NUCLEOSIDE ANALOG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HYPERGAMMAGLOBULINEMIA; LYMPHADENOPATHY; MOUSE; NONHUMAN; PHAGOCYTOSIS; PHOSPHORYLATION; PRIORITY JOURNAL; SPLENOMEGALY; VIRUS INFECTIVITY; VIRUS INHIBITION;

ANIMAL; ANTIVIRAL AGENTS; DEOXYCYTOSINE NUCLEOTIDES; ERYTHROCYTE MEMBRANE; HUMAN; IN VITRO; MACROPHAGES; MICE; MURINE ACQUIRED IMMUNODEFICIENCY SYNDROME; SUPPORT, NON-U.S. GOV'T; VIRUS REPLICATION;

EID: 0026770371     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.89.14.6477     Document Type: Article

References (34)

1. Mitsuya, H., Yarchoan, R. & Broder, S. (1990) Science 249, 1533-1544.
2. Mitsuya, H., Yarchoan, R., Kageyama, S. & Broder, S. (1991) FASEB J. 5, 2369-2381.
3. Yarchoan, R., Perno, C. F., Thomas, R. V., Klecker, R. W., Allain, J. P., Wills, R. J., McAtee, N., Fischl, M. A., Dubinski, R., McNeely, M. C., Mitsuya, H., Pluda, J. M., Lawley, T. J., Leuther, M., Safai, B., Collins, J. M., Myers, C. E. & Broder, S. (1988) Lancet i, 76-81.
4. Broder, S. (1990) Am. J. Med. 88, 1S-7S.
5. Cooley, T. P., Kunches, L. M., Saunders, C. A., Ritter, J. K., Perkins, C. J., McLaren, C., McCaffrey, R. P. & Liebman, H. A. (1990) N. Engl. J. Med. 322, 1340-1345.
6. Lambert, J. S., Seidlin, M., Reichman, R. C., Plank, C. S., Laverty, M., Morse, G. D., Knupp, C., McLaren, C., Pettinelli, C., Valentine, F. T. & Dolin, R. (1990) N. Engl. J. Med. 322, 1333-1340.
7. Balzarini, J., Pauwels, R., Baba, M., Herdewijn, P., De Clerq, E., Broder, S. & Johns, D. G. (1988) Biochem. Pharmacol. 37, 893-903.
8. Szebeni, J., Wahl, S. M., Popovic, M., Wahl, L. M., Gartner, S., Fine, R. L., Skaleric, U., Friedman, R. M. & Weinstein, J. N. (1989) Proc. Natl. Acad. Sci. USA 86, 3842-3846.
9. Patel, S. S., Szebeni, J., Wahl, L. M. & Weinstein, J. N. (1991) Antimicrob. Agents Chemother. 35, 1250-1253.
10. Mosier, D. E., Yetter, R. A. & Morse, H. C., III (1987) J. Exp. Med. 165, 1737-1742.
11. Brandi, G., Rossi, L., Schiavano, G. F., Salvaggio, L., Albano, A. & Magnani, M. (1991) Chem. Biol. Interactions 79, 53-64.
12. Salhany, J. M. (1990) Erythrocyte Band 3 Protein (CRC, Boca Raton, FL), p. 213.
13. Clague, M. J. & Cherry, R. J. (1989) Biochim. Biophys. Acta 920, 93-99.
14. Hui, S. W., Stewart, C. M. & Cherry, R. J. (1990) Biochim. Biophys. Acta 1023, 335-340.
15. Lelkes, G., Fodor, I., Lelkes, G. & Hollman, S. (1986) J. Cell Sci. 86, 57-67.
16. Low, P. S. (1989) in Red Blood Cell Membranes, eds. Agre, P. & Parker, J. C. (Dekker, New York), pp. 237-260.
17. Lutz, H. U., Bussolino, F., Flepp, R., Fasler, S., Kazatchkine, M. D. & Arese, P. (1987) Proc. Natl. Acad. Sci. USA 84, 7368-7372.
18. Turrini, F., Arese, P., Yuan, J. & Low, P. S. (1991) J. Biol. Chem. 266, 23611-23617.
19. Meltzer, M. S., Skillman, D. R., Gomatos, P. J., Kalter, D. C. & Gendelmen, H. E. (1990) Annu. Rev. Immunol. 8, 169-194.
20. Gartner, S., Markovitz, P., Markovitz, D. M., Kaplan, M. H., Gallo, R. C. & Popovic, M. (1986) Science 233, 215-219.
21. Valentin, A., Jan, A., Fenyo, E. M. & Asjo, E. M. (1990) Virology 177, 790-794.
22. Yarchoan, R. & Broder, S. (1989) in Fundamental Immunology, ed. Paul, E. (Raven, New York), pp 1059-1079.
23. Jolicoeur, P. (1991) FASEB J. 5, 2398-2405.
24. Gangemi, J. D., Cozens, R. M., De Clerq, E., Balzarini, J. & Hochkeppel, H. K. (1989) Antimicrob. Agents Chemother. 33, 1864-1868.
25. Ohnota, H., Okada, Y., Ushijima, H., Kitamura, T., Komuro, K. & Mizuochi, T. (1990) Antimicrob. Agents Chemother. 34, 605-609.
26. Basham, T., Holdener, T. & Merigan, T. (1991) J. Infect. Dis. 163, 869-872.
27. Hersh, E. M., Funk, C. Y., Ryschon, K. L., Petersen, E. A. & Mosier, D. E. (1991) AIDS Res. Hum. Retroviruses 7, 553-561.
28. Mitsuya, H. & Broder, S. (1987) Nature (London) 325, 773-778.
29. Cooney, D. A., Dalal, M., Mitsuya, N., McMahon, J. B., Nadkarni, M., Baizarini, J., Broder, S. & Johns, D. G. (1986) Biochem. Pharmacol. 35, 2065-2068.
30. Starnes, M. C. & Cheng, Y. C. (1987) J. Biol. Chem. 262, 988-991.
31. Ahluwalia, G., Cooney, D. A., Mitsuya, H., Fridland, A., Flora, K. P., Hao, A., Dalal, M., Broder, S. & Johns, D. G. (1987) Biochem. Pharmacol. 36, 3797-3800.
32. Carson, D. A., Haertle, T., Wasson, D. B. & Richman, D. D. (1988) Biochem. Biophys. Res. Commun. 151, 788-793.
33. Johnson, M. A., Ahluwalia, G., Connelly, M. C., Cooney, D. A., Broder, S., Johns, D. G. & Fridland, A. (1988) J. Biol. Chem. 23, 15354-15357.
34. Green, R. & DeLoach, J. R., eds. (1991) Resealed Erythrocytes as Carriers and Bioreactors (Pergamon, Oxford), p. 252.