Metabolism of calcium antagonist ro 40-5967: A case history of the use of diode-array U.V. Spectroscopy and thermospray-mass spectrometry in the elucidation of a complex metabolic pathway

Xenobiotica

Volumn 22, Issue 7, 1992, Pages 837-857

  Wiltshire, H R ^a   Harris, S R ^a   Prior, K J ^a   Kozlowski, U M ^a   Worth, E ^a  

^a ROCHE PRODUCTS LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ANTAGONIST; DRUG METABOLITE; MIBEFRADIL;

ANIMAL EXPERIMENT; ARTICLE; BILIARY EXCRETION; DRUG METABOLISM; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; ULTRAVIOLET SPECTROSCOPY;

ANIMAL; BENZIMIDAZOLES; CALCIUM CHANNEL BLOCKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIBEFRADIL; RATS; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTRUM ANALYSIS; SPECTRUM ANALYSIS, MASS; TETRAHYDRONAPHTHALENES;

EID: 0026768078     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.3109/00498259209053144     Document Type: Article

References (6)

1. Tocainide conjugation in humans: novel biotransformation pathway for a primary amine
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3. Ro 40–5967, a calcium antagonist of a new generation?
4. Characterization of a carbamic ester glucuronide of the secondary amine sertraline
5. Ro 40–5967: pharmacokinetics of a new calcium antagonist
6. Biotransformation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino [4,5-c]pyrrolidine maleate in rats