Expression of the tumour suppressor gene p53 in oral cancer

British Journal of Oral and Maxillofacial Surgery

Volumn 30, Issue 4, 1992, Pages 214-220

  Langdon, J D ^a   Partridge, M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEIN P53;

ALCOHOL CONSUMPTION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC DAMAGE; HUMAN; HUMAN TISSUE; LEUKOPLAKIA; MOUTH CANCER; MUTANT; SMOKING HABIT; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

ALCOHOL DRINKING; ANTIBODIES, MONOCLONAL; CARCINOMA, SQUAMOUS CELL; CELL NUCLEUS; CYTOPLASM; EPITOPES; ERYTHROPLASIA; GENE EXPRESSION; GENES, P53; HUMAN; IMMUNOENZYME TECHNIQUES; KI-67 ANTIGEN; LEUKOPLAKIA, ORAL; LYMPH NODES; MOUTH MUCOSA; MOUTH NEOPLASMS; NEOPLASM RECURRENCE, LOCAL; NUCLEAR PROTEINS; PROTEIN P53; SMOKING; SUPPORT, NON-U.S. GOV'T; SURVIVAL RATE;

EID: 0026763465     PISSN: 02664356     EISSN: None     Source Type: Journal    
DOI: 10.1016/0266-4356(92)90263-I     Document Type: Article

References (22)

1. Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro
2. Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines
3. p53 expression in breast cancer
4. The cellular protein p53 in human tumours
5. Elevated expression of the c-myc oncoprotein correlates with poor prognosis in head and neck squamous cell carcinoma
6. Elevated p53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck
7. The p53 proto-oncogene can act as a suppressor of transformation
8. Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cellular proliferation
9. Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form
10. Expression of p53 in premalignant and malignant squamous epithelium
11. Mutation is required to activate the p53 gene for co-operation with the ras oncogene and transformation
12. Increased expression of mutant forms of p53 oncogene in primary lung cancer
13. T-antigen is bound to host protein in SV 40 transformed cells
14. p53: oncogene or anti-oncogene?
15. Mutations in the p53 gene occur in diverse human tumour types
16. Specific interaction between the p53 tumour antigen and major antigen and major heat shock proteins
17. Two binding sites for Ki67 related to quiescent and cycling cells in human epidermis
18. p53 mutations in colorectal cancer
19. Low incidence of ras oncogene activation in human squamous cell carcinomas
20. Oncogene activation in squamous cell carcinoma of the oral cavity
21. Analysis of the c-Harasl gene for deletion, mutation, amplification and expression in lymph node metastases of human head and neck carcinomas
22. Precise epitope mapping of the murine transformation-associated protein, p53