Parathyroid hormone decreases HCO3 reabsorption in the rat proximal tubule by stimulating phosphatidylinositol metabolism and inhibiting base exit

Journal of Clinical Investigation

Volumn 89, Issue 5, 1992, Pages 1485-1495

  Pastoriza Munoz, Enrique ^a   Harrington, Robin M ^b   Graber, Mark L ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NONE

Author keywords

Acidification; cAMP; Intracellular calcium; Intracellular pH; Phosphatidylinositol metabolism

Indexed keywords

BICARBONATE; PHOSPHATIDYLINOSITOL;

ACIDIFICATION; ANIMAL CELL; ANION EXCHANGE; ARTICLE; CALCIUM CELL LEVEL; CELL PH; INHIBITION KINETICS; KIDNEY PERFUSION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; LIPID METABOLISM; NONHUMAN; PARATHYROID HORMONE RELEASE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTON TRANSPORT; RAT;

ANIMAL; BICARBONATES; BIOLOGICAL TRANSPORT; CALCIUM; CARRIER PROTEINS; CYCLIC AMP; HYDROGEN-ION CONCENTRATION; KIDNEY TUBULES, PROXIMAL; PARATHYROID HORMONES; PHOSPHATIDYLINOSITOLS; PROTEIN KINASE C; RATS; RATS, INBRED STRAINS; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.;

EID: 0026763060     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI115739     Document Type: Article

References (17)

1. McKinney, T. D., and P. Myers. 1980. Bicarbonate transport by proximal tubules effect of parathyroid hormone and dibutyryl cyclic AMP. Am. J. Physiol. 238(Renal Fluid Electrolyte Physiol. 7):F 166-F174.
2. + exchanger in renal microvillous membrane vesicles. Am. J. Physiol. 238:F461-F469.
3. - transport in the rat proximal convoluted tubule: a sodium-coupled electrogenic process. J. Gen. Physiol. 86:613-636.
4. + exchange in renal brush border vesicles. Am. J. Physiol. 248(Renal Fluid Electrolyte Physiol.):F212-F218.
5. + antiporter activity in a cultured renal cell line. Am. J. Physiol. 250(Renal Fluid Electrolyte Physiol. 19):F217-F225.
6. Agus, Z. S., J. B. Puschett, D. Senesky, and M. Goldberg. 1971. Mode of action of parathyroid hormone and cyclic adenosine 3′-5′-monophosphate on renal tubular phosphate reabsorption in the dog. J. Clin. Invest. 50:617-626.
7. Pastoriza-Munoz, F., R. F. Colindres, W. E. Lassiter, and C. Lechene. 1978. Effect of parathyroid hormone on phosphate reabsorption in rat distal convolution. Am. J. Physiol. 235:F321-F330.
8. Chen, P. S., T. Y. Toribara, and H. Warner. 1956. Microdetermination of Phosphorus. Anal. Chem. 28:1756-1758.
9. Vurek, G. C., D. G. Warnock, and R. Corsey. 1978. Measurement of picomole amounts of carbon dioxide by calorimetry. Anal. Chem. 47:765-767.
10. Pastoriza-Munoz, E., R. M. Harrington, and M. I., Graber. 1987. Axial heterogeneity of intracellular pH in rat proximal convoluted tubule. J. Clin. Invest. 80:207-215.
11. DuBose, T. D., Jr., L. R. Pucacco, M. S. Lucci, and N. W. Carter. 1979.
12. 2 concentration in accessible structures of the rat renal cortex. J. Clin. Invest. 64:476-482.
13. Boron, W. F., and H. Sackin. 1983. Measurement of intracellular ionic composition and activities in renal tubules. Annu. Rev. Physiol. 45:483-496.
14. 2+ indicators with greatly improved tluorescence properties. J. Biol. Chem. 260:3440-3450.
15. 3 (OH) exit. Pfluegers Arch. Eur. J. Physiol. 402:300-305.
16. Alpern, R. J., and M. Chambers. 1986. Cell pH in rat proximal convoluted tubule. Regulation by luminal and peritubular pH and sodium concentration. J. Clin. Invest. 78:502-510.
17. Ramsammy, L. S., C. Josepovitz, and G. J. Kaloyanides. 1988. Gentamicin inhibits agonist stimulation of the phosphatidylinositol cascade in primary cultures of rabbit proximal tubular cells and in rat renal cortex. J. Pharmacol. Exp. Ther. 247:989-996.