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Volumn 10, Issue , 1992, Pages 489-518

Transgenic mice and analysis of B-cell tolerance

Author keywords

anergy; autoimmunity; B lymphocyte; deletion; immunoglobulin gene

Indexed keywords

ANERGY; ANIMAL CELL; ANIMAL EXPERIMENT; AUTOIMMUNITY; B LYMPHOCYTE; IMMUNOGLOBULIN GENE; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRANSGENIC MOUSE;

EID: 0026762942     PISSN: 03013782     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.iy.10.040192.002421     Document Type: Review
Times cited : (326)

References (206)
  • 2
    • 0000658958 scopus 로고
    • Immunogenetic consequences of vascular anastomoses between bovine twins
    • Owen, R. D. 1945. Immunogenetic consequences of vascular anastomoses between bovine twins. Science 102: 400-1
    • (1945) Science , vol.102 , pp. 400-401
    • Owen, R.D.1
  • 3
    • 85019277983 scopus 로고
    • Factors influencing the persistence of choriomeningitis virus in the blood after clinical recovery
    • Traub, E. 1938. Factors influencing the persistence of choriomeningitis virus in the blood after clinical recovery. J. Exp. Med. 68: 229-51
    • (1938) J. Exp. Med. , vol.68 , pp. 229-251
    • Traub, E.1
  • 5
    • 0005984244 scopus 로고
    • Actively acquired tolerance of foreign cells
    • Billingham, R. E., Brent, L., Medawar, P. B. 1953. Actively acquired tolerance of foreign cells. Nature 172: 603-6
    • (1953) Nature , vol.172 , pp. 603-606
    • Billingham, R.E.1    Brent, L.2    Medawar, P.B.3
  • 7
    • 0000590741 scopus 로고
    • Genes and antibodies
    • Lederberg, J. 1959. Genes and antibodies. Science 129: 1649-53
    • (1959) Science , vol.129 , pp. 1649-1653
    • Lederberg, J.1
  • 8
    • 0020977755 scopus 로고
    • Cellular mechanisms of immunologic tolerance
    • Nossal, G. J. V. 1983. Cellular mechanisms of immunologic tolerance. Annu. Rev. Immunol. 1: 33-62
    • (1983) Annu. Rev. Immunol. , vol.1 , pp. 33-62
    • Nossal, G.J.V.1
  • 9
    • 0015912922 scopus 로고
    • Lymphocytes binding human thyroglobulin in healthy people and its relevance to tolerance for autoantigens
    • Bankhurst, A. D., Torrigiani, G., Allison, A. C. 1975. Lymphocytes binding human thyroglobulin in healthy people and its relevance to tolerance for autoantigens. Lancet i: 226-29
    • (1975) Lancet , vol.1 , pp. 226-229
    • Bankhurst, A.D.1    Torrigiani, G.2    Allison, A.C.3
  • 10
    • 0015855807 scopus 로고
    • Tolerance to an autoantigen-thyroglobulin. Antigen-binding lymphocytes in thymus and blood in health and autoimmune disease
    • Roberts, I. M., Whittingham, S., Mackay, I. R. 1973. Tolerance to an autoantigen-thyroglobulin. Antigen-binding lymphocytes in thymus and blood in health and autoimmune disease. Lancet ii: 936-40
    • (1973) Lancet , vol.2 , pp. 936-940
    • Roberts, I.M.1    Whittingham, S.2    Mackay, I.R.3
  • 11
    • 0016149434 scopus 로고
    • Large numbers of cells in normal mice produce antibody to components of isologous erythrocytes
    • Cunningham, A. J. 1974. Large numbers of cells in normal mice produce antibody to components of isologous erythrocytes. Nature 252: 749
    • (1974) Nature , vol.252 , pp. 749
    • Cunningham, A.J.1
  • 12
    • 0017357082 scopus 로고
    • Characterization of self-reactive B cells by polyclonal B-cell activators
    • Primi, D., Hammarstrom, L., Smith, C. I. E., Moller, G. 1977. Characterization of self-reactive B cells by polyclonal B-cell activators. J. Exp. Med. 145: 21-30
    • (1977) J. Exp. Med. , vol.145 , pp. 21-30
    • Primi, D.1    Hammarstrom, L.2    Smith, C.I.E.3    Moller, G.4
  • 13
    • 1242335473 scopus 로고
    • Infectious immunological tolerance
    • Gershon, R. K., Kondo, K. 1971. Infectious immunological tolerance. Immunology 21: 181-92
    • (1971) Immunology , vol.21 , pp. 181-192
    • Gershon, R.K.1    Kondo, K.2
  • 15
    • 0015956495 scopus 로고
    • Towards a network theory of the immune system
    • Jerne, N. K. 1971. Towards a network theory of the immune system. Ann. Immunol. (Inst. Pasteur) 125C: 373-89
    • (1971) Ann. Immunol. (Inst. Pasteur) , vol.125 C , pp. 373-389
    • Jerne, N.K.1
  • 16
    • 0022931326 scopus 로고
    • Antibody repertoires of normal BALB/c mice: B lymphocyte populations defined by state of activation
    • Holmberg, D., Freitas, A. A., Portnoï, D., Jacquemart, F., Avrameas, S., Coutinho, A. 1986. Antibody repertoires of normal BALB/c mice: B lymphocyte populations defined by state of activation. Immunol. Rev. 93: 147-69
    • (1986) Immunol. Rev. , vol.93 , pp. 147-169
    • Holmberg, D.1    Freitas, A.A.2    Portnoï, D.3    Jacquemart, F.4    Avrameas, S.5    Coutinho, A.6
  • 17
    • 0642282753 scopus 로고
    • Tolerance to a protein antigen in adult mice and the effect of nonspecific factors
    • Claman, H. N. 1963. Tolerance to a protein antigen in adult mice and the effect of nonspecific factors. J. Immunol. 91: 833-39
    • (1963) J. Immunol. , vol.91 , pp. 833-839
    • Claman, H.N.1
  • 18
    • 0014941813 scopus 로고
    • A theory of self-nonself discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively
    • Bretscher, P., Cohn, M. 1970. A theory of self-nonself discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively. Science 163: 1042-49
    • (1970) Science , vol.163 , pp. 1042-1049
    • Bretscher, P.1    Cohn, M.2
  • 20
    • 0024327899 scopus 로고
    • Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy
    • Mueller, D. L., Jenkins, M. K., Schwartz, R. H. 1989. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7: 445-80
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 445-480
    • Mueller, D.L.1    Jenkins, M.K.2    Schwartz, R.H.3
  • 21
    • 0024955886 scopus 로고
    • Approaching the asymptote? Evolution and revolution in immunology
    • Janeway, C. A. 1989. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harbor Symp. Quant. Biol. 54: 1-13
    • (1989) Cold Spring Harbor Symp. Quant. Biol. , vol.54 , pp. 1-13
    • Janeway, C.A.1
  • 22
    • 0002480407 scopus 로고
    • Immunological tolerance of nonliving antigens
    • Smith, R. T. 1961. Immunological tolerance of nonliving antigens. Adv. Immunol. 1: 67-129
    • (1961) Adv. Immunol. , vol.1 , pp. 67-129
    • Smith, R.T.1
  • 23
    • 0014224276 scopus 로고
    • The mechanism of immunological paralysis
    • Dresser, D. W., Mitchison, N. A. 1968. The mechanism of immunological paralysis. Adv. Immunol. 8: 129-81
    • (1968) Adv. Immunol. , vol.8 , pp. 129-181
    • Dresser, D.W.1    Mitchison, N.A.2
  • 25
    • 0014555497 scopus 로고
    • The tolerance inducing properties in rats of bacterial flagellin cleaved at the methionine residues
    • Parish, C. R., Ada, G. L. 1969. The tolerance inducing properties in rats of bacterial flagellin cleaved at the methionine residues. Immunology 17: 153-64
    • (1969) Immunology , vol.17 , pp. 153-164
    • Parish, C.R.1    Ada, G.L.2
  • 26
    • 0015099286 scopus 로고
    • Immune response to chemically modified flagellin I. Induction of antibody tolerance to flagellin by acetoacetylated derivatives of the protein
    • Parish, C. R. 1971. Immune response to chemically modified flagellin I. Induction of antibody tolerance to flagellin by acetoacetylated derivatives of the protein. J. Exp. Med. 134: 1-20
    • (1971) J. Exp. Med. , vol.134 , pp. 1-20
    • Parish, C.R.1
  • 27
    • 0015546974 scopus 로고
    • Immunological unresponsiveness
    • Weigle, W. O. 1973. Immunological unresponsiveness. Adv. Immunol. 16: 61-122
    • (1973) Adv. Immunol. , vol.16 , pp. 61-122
    • Weigle, W.O.1
  • 28
    • 0015382576 scopus 로고
    • The mechanism of antigenic stimulation of primary and secondary clonal precursor cells
    • Klinman, N. R. 1972. The mechanism of antigenic stimulation of primary and secondary clonal precursor cells. J. Exp. Med. 136: 241-60
    • (1972) J. Exp. Med. , vol.136 , pp. 241-260
    • Klinman, N.R.1
  • 29
    • 0018771525 scopus 로고
    • Murine models of tolerance induction in developing and mature B cells
    • Metcalf, E. S., Schrater, A. F., Klinman, N. R. 1979. Murine models of tolerance induction in developing and mature B cells. Immunol. Rev. 43: 143-83
    • (1979) Immunol. Rev. , vol.43 , pp. 143-183
    • Metcalf, E.S.1    Schrater, A.F.2    Klinman, N.R.3
  • 31
    • 0021801198 scopus 로고
    • A high-efficiency cloning system for single hapten-specific B lymphocytes that is suitable for assay of putative growth and differentiation factors
    • Pike, B. L., Nossal, G. J. V. 1985. A high-efficiency cloning system for single hapten-specific B lymphocytes that is suitable for assay of putative growth and differentiation factors. Proc. Natl. Acad. Sci. USA 82: 3395-99
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 3395-3399
    • Pike, B.L.1    Nossal, G.J.V.2
  • 32
    • 0014276973 scopus 로고
    • Further improvements in the plaque technique for detecting single antibody-forming cells
    • Cunningham, A. J., Szenberg, A. 1968. Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology 14: 599-601
    • (1968) Immunology , vol.14 , pp. 599-601
    • Cunningham, A.J.1    Szenberg, A.2
  • 33
    • 0017135663 scopus 로고
    • Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion
    • Kohler, G., Milstein, C. 1976. Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion. Eur. J. Immunol. 6: 511-19
    • (1976) Eur. J. Immunol. , vol.6 , pp. 511-519
    • Kohler, G.1    Milstein, C.2
  • 34
    • 0014586152 scopus 로고
    • An in vitro reaction between labelled flagellin or haemocyanin and lymphocyte-like cells from normal animals
    • Byrt, P., Ada, G. L. 1969. An in vitro reaction between labelled flagellin or haemocyanin and lymphocyte-like cells from normal animals. Immunology 17: 503-16
    • (1969) Immunology , vol.17 , pp. 503-516
    • Byrt, P.1    Ada, G.L.2
  • 35
    • 0018322485 scopus 로고
    • Cell fractionation methods and the target cells for clonal abortion of B lymphocytes
    • Nossal, G. J. V., Pike, B. L., Teale, J. M., Layton, J. E., Kay, T. W., Battye, F. L. 1979. Cell fractionation methods and the target cells for clonal abortion of B lymphocytes. Immunol. Rev. 43: 185-216
    • (1979) Immunol. Rev. , vol.43 , pp. 185-216
    • Nossal, G.J.V.1    Pike, B.L.2    Teale, J.M.3    Layton, J.E.4    Kay, T.W.5    Battye, F.L.6
  • 36
    • 0011869916 scopus 로고
    • Clonal anergy: Persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen
    • Nossal, G. J. V., Pike, B. L. 1980. Clonal anergy: persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen. Proc. Natl. Acad. Sci. USA 77: 1602-6
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 1602-1606
    • Nossal, G.J.V.1    Pike, B.L.2
  • 37
    • 0020614407 scopus 로고
    • Clonal anergy: Inhibition of antigen-driven proliferation among single B lymphocytes from tolerant animals and partial breakage of anergy by mitogens
    • Pike, B. L., Abrams, J., Nossal, G. J. V. 1983. Clonal anergy: inhibition of antigen-driven proliferation among single B lymphocytes from tolerant animals and partial breakage of anergy by mitogens. Eur. J. Immunol. 13: 214-20
    • (1983) Eur. J. Immunol. , vol.13 , pp. 214-220
    • Pike, B.L.1    Abrams, J.2    Nossal, G.J.V.3
  • 38
    • 0022931253 scopus 로고
    • Murine natural monoclonal autoantibodies: A study of their polyspecificities and their affinities
    • Ternynck, T., Avrameas, S. 1986. Murine natural monoclonal autoantibodies: a study of their polyspecificities and their affinities. Immunol. Rev. 94: 99-112
    • (1986) Immunol. Rev. , vol.94 , pp. 99-112
    • Ternynck, T.1    Avrameas, S.2
  • 39
    • 0023220849 scopus 로고
    • The autoantigen-binding B cell repertoires of normal and of chronically graft-versus-host-diseased mice
    • Rolink, A. G., Radaszkiewicz, T., Melchers, F. 1987. The autoantigen-binding B cell repertoires of normal and of chronically graft-versus-host-diseased mice. J. Exp. Med. 165: 1675-87
    • (1987) J. Exp. Med. , vol.165 , pp. 1675-1687
    • Rolink, A.G.1    Radaszkiewicz, T.2    Melchers, F.3
  • 40
    • 0023223942 scopus 로고
    • Clonal analysis of the anti-DNA repertoire of murine B lymphocytes
    • Conger, J. D., Pike, B. L., Nossal, G. J. V. 1987. Clonal analysis of the anti-DNA repertoire of murine B lymphocytes. Proc. Natl. Acad. Sci. USA 84: 2931-35
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 2931-2935
    • Conger, J.D.1    Pike, B.L.2    Nossal, G.J.V.3
  • 41
    • 0024260057 scopus 로고
    • Clonal analysis of autoantibody-producing cell precursors in the preimmune B cell repertoire
    • McHeyzer-Williams, M. G., Nossal, G. J. V. 1988. Clonal analysis of autoantibody-producing cell precursors in the preimmune B cell repertoire. J. Immunol. 141: 4118-23
    • (1988) J. Immunol. , vol.141 , pp. 4118-4123
    • McHeyzer-Williams, M.G.1    Nossal, G.J.V.2
  • 42
    • 0024374764 scopus 로고
    • Probing the human B cell repertoire with EBV: Polyreactive antibodies and CD5+ B lymphocytes
    • Casali, P., Notkins, A. L. 1989. Probing the human B cell repertoire with EBV: polyreactive antibodies and CD5+ B lymphocytes. Annu. Rev. Immunol. 7: 513-35
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 513-535
    • Casali, P.1    Notkins, A.L.2
  • 43
    • 0023103574 scopus 로고
    • Isolation of high-affinity memory B cells: Phycoerythrin as a probe for antigen-binding cells
    • Hayakawa, K., Ishi, R., Yamasaki, K., Kishimoto, T., Hardy, R. R. 1987. Isolation of high-affinity memory B cells: phycoerythrin as a probe for antigen-binding cells. Proc. Natl. Acad. Sci. USA 84: 1379-83
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 1379-1383
    • Hayakawa, K.1    Ishi, R.2    Yamasaki, K.3    Kishimoto, T.4    Hardy, R.R.5
  • 44
    • 0024989657 scopus 로고
    • Maintenance of B-cell memory by long-lived cells generated from proliferating precursors
    • Schittek, B., Rajewsky, K. 1990. Maintenance of B-cell memory by long-lived cells generated from proliferating precursors. Nature 346: 749-51
    • (1990) Nature , vol.346 , pp. 749-751
    • Schittek, B.1    Rajewsky, K.2
  • 45
    • 0025783070 scopus 로고
    • Molecular characterization of single memory B cells
    • McHeyzer-Williams, M. G., Nossal, G. J. V., Lalor, P. A. 1991. Molecular characterization of single memory B cells. Nature 350: 502-5
    • (1991) Nature , vol.350 , pp. 502-505
    • McHeyzer-Williams, M.G.1    Nossal, G.J.V.2    Lalor, P.A.3
  • 51
    • 0024603185 scopus 로고
    • The immune response of BALB/c mice to influenza hemagglutinin: Commonality of the B cell and T cell repertoires and their relevance to antigenic drift
    • Barnett, B. C., Graham, C. M., Burt, D. S., Skehel, J. J., Thomas, D. B. 1989. The immune response of BALB/c mice to influenza hemagglutinin: commonality of the B cell and T cell repertoires and their relevance to antigenic drift. Eur. J. Immunol. 19: 515-21
    • (1989) Eur. J. Immunol. , vol.19 , pp. 515-521
    • Barnett, B.C.1    Graham, C.M.2    Burt, D.S.3    Skehel, J.J.4    Thomas, D.B.5
  • 52
    • 0025275488 scopus 로고
    • A role for immunogenic DNA in the pathogenesis of systemic lupus erythematosus
    • Pisetsky, D. S., Grudier, J. P., Gilkeson, G. S. 1990. A role for immunogenic DNA in the pathogenesis of systemic lupus erythematosus. Arthritis Rheum. 33: 153-59
    • (1990) Arthritis Rheum. , vol.33 , pp. 153-159
    • Pisetsky, D.S.1    Grudier, J.P.2    Gilkeson, G.S.3
  • 53
    • 0024520930 scopus 로고
    • Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA
    • Gilkeson, G. S., Grudier, J. P., Karounos, D. G., Pisetsky, D. S. 1989. Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA. J. Immunol. 142: 1482-86
    • (1989) J. Immunol. , vol.142 , pp. 1482-1486
    • Gilkeson, G.S.1    Grudier, J.P.2    Karounos, D.G.3    Pisetsky, D.S.4
  • 55
    • 0016000312 scopus 로고
    • Modification of B lymphocyte differentiation by anti-immunoglobulins
    • Lawton, A. R., Cooper, M. D. 1974. Modification of B lymphocyte differentiation by anti-immunoglobulins. Contemp. Top. Immunobiol. 3: 193-225
    • (1974) Contemp. Top. Immunobiol. , vol.3 , pp. 193-225
    • Lawton, A.R.1    Cooper, M.D.2
  • 56
    • 0023248737 scopus 로고
    • In vivo generation and function of B cells in the presence of a monoclonal anti-IgM antibody: Implications for B cell tolerance
    • Gause, A., Yoshida, N., Kappen, C., Rajewsky, K. 1987. In vivo generation and function of B cells in the presence of a monoclonal anti-IgM antibody: implications for B cell tolerance. Eur. J. Immunol. 17: 981-90
    • (1987) Eur. J. Immunol. , vol.17 , pp. 981-990
    • Gause, A.1    Yoshida, N.2    Kappen, C.3    Rajewsky, K.4
  • 57
    • 0016849342 scopus 로고
    • Receptor-mediated inactivation of early B lymphocytes
    • Sidman, C. L., Unanue, E. R. 1975. Receptor-mediated inactivation of early B lymphocytes. Nature 257: 149-51
    • (1975) Nature , vol.257 , pp. 149-151
    • Sidman, C.L.1    Unanue, E.R.2
  • 58
    • 0016827667 scopus 로고
    • Differences in susceptibility of mature and immature mouse B lymphocytes to anti-immunoglobulin-induced immunoglobulin suppression in vitro
    • Raff, M. C., Owen, J. J. T., Cooper, M. D., Lawton, A. R., Megson, M., Gathings, W. E. 1975. Differences in susceptibility of mature and immature mouse B lymphocytes to anti-immunoglobulin-induced immunoglobulin suppression in vitro. J. Exp. Med. 142: 1052-64
    • (1975) J. Exp. Med. , vol.142 , pp. 1052-1064
    • Raff, M.C.1    Owen, J.J.T.2    Cooper, M.D.3    Lawton, A.R.4    Megson, M.5    Gathings, W.E.6
  • 62
    • 0018140688 scopus 로고
    • Stimulation of murine B lymphocytes to IgG synthesis and secretion by the mitogens lipopolysaccharide and lipoprotein and its inhibition by anti-immunoglobulin antibodies
    • Andersson, J., Coutinho, A., Melchers, F. 1978. Stimulation of murine B lymphocytes to IgG synthesis and secretion by the mitogens lipopolysaccharide and lipoprotein and its inhibition by anti-immunoglobulin antibodies. Eur. J. Immunol. 8: 336-43
    • (1978) Eur. J. Immunol. , vol.8 , pp. 336-343
    • Andersson, J.1    Coutinho, A.2    Melchers, F.3
  • 63
    • 0017891304 scopus 로고
    • B cell differentiation induced by lipopolysaccharide: V. Suppression of plasma cell maturation by anti-μ: mode of action and characteristics of suppressed cells
    • Kearney, J. F., Klein, J., Bockman, D. E., Cooper, M. D., Lawton, A. R. 1978. B cell differentiation induced by lipopolysaccharide: V. Suppression of plasma cell maturation by anti-μ: mode of action and characteristics of suppressed cells. J. Immunol. 120: 158-66
    • (1978) J. Immunol. , vol.120 , pp. 158-166
    • Kearney, J.F.1    Klein, J.2    Bockman, D.E.3    Cooper, M.D.4    Lawton, A.R.5
  • 64
    • 0011855456 scopus 로고
    • IgM RNA switch from membrane to secretory form is prevented by adding antireceptor antibody to bacterial lipopolysaccharide-stimulated murine primary B-cell cultures
    • Chen-Bettecken, U., Wecker, E., Shimpl, A. 1985. IgM RNA switch from membrane to secretory form is prevented by adding antireceptor antibody to bacterial lipopolysaccharide-stimulated murine primary B-cell cultures. Proc. Natl. Acad. Sci. USA 82: 7384-88
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 7384-7388
    • Chen-Bettecken, U.1    Wecker, E.2    Shimpl, A.3
  • 65
    • 0021847953 scopus 로고
    • Anti-IgM treatment influences immunoglobulin heavy and light chain mRNA levels in mitogen-stimulated B lymphocytes
    • Leanderson, T., Hsu, E. 1985. Anti-IgM treatment influences immunoglobulin heavy and light chain mRNA levels in mitogen-stimulated B lymphocytes. Eur. J. Immunol. 15: 641-43
    • (1985) Eur. J. Immunol. , vol.15 , pp. 641-643
    • Leanderson, T.1    Hsu, E.2
  • 66
    • 0021966190 scopus 로고
    • Monoclonal antibodies specific for murine IgM II. Activation of B lymphocytes by monoclonal antibodies specific for the four constant domains of IgM
    • Leptin, M. 1985. Monoclonal antibodies specific for murine IgM II. Activation of B lymphocytes by monoclonal antibodies specific for the four constant domains of IgM. Eur. J. Immunol. 15: 131-37
    • (1985) Eur. J. Immunol. , vol.15 , pp. 131-137
    • Leptin, M.1
  • 67
    • 0023607033 scopus 로고
    • Mechanism of suppression of lipopolysaccharide-driven B cell differentiation by anti-μ antibodies: Evidence for a trans-acting repressor of transcription
    • Flahart, R. E., Lawton, A. R. 1987. Mechanism of suppression of lipopolysaccharide-driven B cell differentiation by anti-μ antibodies: Evidence for a trans-acting repressor of transcription. J. Exp. Med. 166: 864-73
    • (1987) J. Exp. Med. , vol.166 , pp. 864-873
    • Flahart, R.E.1    Lawton, A.R.2
  • 68
    • 0023796688 scopus 로고
    • Activation events in hapten-specific B cells from tolerant mice
    • Chace, J. H., Scott, D. W. 1988. Activation events in hapten-specific B cells from tolerant mice. J. Immunol. 141: 3258-62
    • (1988) J. Immunol. , vol.141 , pp. 3258-3262
    • Chace, J.H.1    Scott, D.W.2
  • 69
    • 0019194740 scopus 로고
    • Tolerance as an active process
    • Teale, J. M., Klinman, J. M. 1980. Tolerance as an active process. Nature 288: 385-87
    • (1980) Nature , vol.288 , pp. 385-387
    • Teale, J.M.1    Klinman, J.M.2
  • 70
    • 0017098364 scopus 로고
    • Evidence for the inactivation of precursor B cells in high dose unresponsiveness
    • Desaymard, C., Waldmann, H. 1976. Evidence for the inactivation of precursor B cells in high dose unresponsiveness. Nature 264: 780-82
    • (1976) Nature , vol.264 , pp. 780-782
    • Desaymard, C.1    Waldmann, H.2
  • 71
    • 0021204064 scopus 로고
    • Membrane and metabolic requirements for tolerance induction of neonatal B cells
    • Teale, J. M., Klinman, N. R. 1984. Membrane and metabolic requirements for tolerance induction of neonatal B cells. J. Immunol. 133: 1811-17
    • (1984) J. Immunol. , vol.133 , pp. 1811-1817
    • Teale, J.M.1    Klinman, N.R.2
  • 72
    • 0019415574 scopus 로고
    • Receptor-ligand interactions and tolerance induction in mature virgin B cells
    • Desaymard, C. 1981. Receptor-ligand interactions and tolerance induction in mature virgin B cells. Cell. Immunology 62: 196-204
    • (1981) Cell. Immunology , vol.62 , pp. 196-204
    • Desaymard, C.1
  • 73
    • 0019451918 scopus 로고
    • The regulation of growth and differentiation of a murine B cell lymphoma. II. The inhibition of WEHI 231 by antiimmunoglobulin antibodies
    • Boyd, A. W., Schrader, J. W. 1981. The regulation of growth and differentiation of a murine B cell lymphoma. II. The inhibition of WEHI 231 by antiimmunoglobulin antibodies. J. Immunol. 126: 2466-69
    • (1981) J. Immunol. , vol.126 , pp. 2466-2469
    • Boyd, A.W.1    Schrader, J.W.2
  • 74
    • 0345121829 scopus 로고
    • WEHI-231 as a tumor model for tolerance induction in immature B lymphocytes
    • ed. E. S. Vitetta, New York: Academic
    • DeFranco, A. L., Davis, M. M., Paul, W. E. 1982. WEHI-231 as a tumor model for tolerance induction in immature B lymphocytes. In B and T Cell Tumours, ed. E. S. Vitetta, pp. 445-50. New York: Academic
    • (1982) B and T Cell Tumours , pp. 445-450
    • DeFranco, A.L.1    Davis, M.M.2    Paul, W.E.3
  • 75
    • 0022881639 scopus 로고
    • Lymphoma models for B cell activation and tolerance. IV. Growth inhibition by anti-Ig of CH31 and CH33 B lymphoma cells
    • Pennell, C. A., Scott, D. W. 1986. Lymphoma models for B cell activation and tolerance. IV. Growth inhibition by anti-Ig of CH31 and CH33 B lymphoma cells. Eur. J. Immunol. 16: 1577-81
    • (1986) Eur. J. Immunol. , vol.16 , pp. 1577-1581
    • Pennell, C.A.1    Scott, D.W.2
  • 78
    • 0023902425 scopus 로고
    • Role of phosphoinositide-derived second messengers in mediating anti-IgM-induced growth arrest of WEHI-231 B lymphoma cells
    • Page, D. M., DeFranco, A. L. 1988. Role of phosphoinositide-derived second messengers in mediating anti-IgM-induced growth arrest of WEHI-231 B lymphoma cells. J. Immunol. 140: 3717-26
    • (1988) J. Immunol. , vol.140 , pp. 3717-3726
    • Page, D.M.1    DeFranco, A.L.2
  • 80
    • 0021076095 scopus 로고
    • Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice
    • Brinster, R. L., Ritchie, K. A., Hammer, R. E., O'Brien, R. L., Arp, B., Storb, U. 1983. Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice. Nature 306: 332-36
    • (1983) Nature , vol.306 , pp. 332-336
    • Brinster, R.L.1    Ritchie, K.A.2    Hammer, R.E.3    O'Brien, R.L.4    Arp, B.5    Storb, U.6
  • 81
    • 0021714531 scopus 로고
    • Introduction of a μ immunoglobulin gene into the mouse germ line: Specific expression in lymphoid cells and synthesis of functional antibody
    • Grosschedl, R., Weaver, D., Baltimore, D., Costantini, F. 1984. Introduction of a μ immunoglobulin gene into the mouse germ line: specific expression in lymphoid cells and synthesis of functional antibody. Cell 38: 647-58
    • (1984) Cell , vol.38 , pp. 647-658
    • Grosschedl, R.1    Weaver, D.2    Baltimore, D.3    Costantini, F.4
  • 82
    • 0021993025 scopus 로고
    • Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line
    • Rusconi, S., Köhler, G. 1985. Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line. Nature 314: 330-34
    • (1985) Nature , vol.314 , pp. 330-334
    • Rusconi, S.1    Köhler, G.2
  • 83
    • 0023068159 scopus 로고
    • Transgenic mice with immunoglobulin genes
    • Storb, U. 1987. Transgenic mice with immunoglobulin genes. Annu. Rev. Immunol. 5: 151-74
    • (1987) Annu. Rev. Immunol. , vol.5 , pp. 151-174
    • Storb, U.1
  • 84
    • 0021680505 scopus 로고
    • Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in κ transgenic mice
    • Ritchie, K. A., Brinster, R. L., Storb, U. 1984. Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in κ transgenic mice. Nature 312: 517-20
    • (1984) Nature , vol.312 , pp. 517-520
    • Ritchie, K.A.1    Brinster, R.L.2    Storb, U.3
  • 85
    • 0022385230 scopus 로고
    • A transgenic immunoglobulin Mu gene prevents rearrangement of endogenous genes
    • Weaver, D., Costantini, F., Imanishi-Kari, T., Baltimore, D. 1985. A transgenic immunoglobulin Mu gene prevents rearrangement of endogenous genes. Cell 42: 117-27
    • (1985) Cell , vol.42 , pp. 117-127
    • Weaver, D.1    Costantini, F.2    Imanishi-Kari, T.3    Baltimore, D.4
  • 87
    • 0023441052 scopus 로고
    • Activation of Vk gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains
    • Reth, M., Petrac, E., Wiese, P., Lobel, L., Alt, F. 1987. Activation of Vk gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains. EMBO J. 6: 3299-3305
    • (1987) EMBO J. , vol.6 , pp. 3299-3305
    • Reth, M.1    Petrac, E.2    Wiese, P.3    Lobel, L.4    Alt, F.5
  • 89
    • 0023685531 scopus 로고
    • Feedback inhibition of immunoglobulin gene rearrangement by membrane u, but not by secreted μ heavy chains
    • Manz, J., Denis, K., Witte, O., Brinster, R., Storb, U. 1988. Feedback inhibition of immunoglobulin gene rearrangement by membrane u, but not by secreted μ heavy chains. J. Exp. Med. 168: 1363-81
    • (1988) J. Exp. Med. , vol.168 , pp. 1363-1381
    • Manz, J.1    Denis, K.2    Witte, O.3    Brinster, R.4    Storb, U.5
  • 90
    • 0025852445 scopus 로고
    • A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene
    • Kitamura, D., Roes, J., Kühn, R., Rajewsky, K. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene. Nature 350: 423-26
    • (1991) Nature , vol.350 , pp. 423-426
    • Kitamura, D.1    Roes, J.2    Kühn, R.3    Rajewsky, K.4
  • 91
    • 0023724209 scopus 로고
    • Positive and negative selection of an antigen receptor on T cells in transgenic mice
    • Sha, W. C., Nelson, C. A., Newberry, R. D., Kranz, D. M., Russell, J. H., Loh, D. Y. 1988. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 336: 73-76
    • (1988) Nature , vol.336 , pp. 73-76
    • Sha, W.C.1    Nelson, C.A.2    Newberry, R.D.3    Kranz, D.M.4    Russell, J.H.5    Loh, D.Y.6
  • 93
    • 0025339512 scopus 로고
    • Self-nonself discrimination by T cells
    • von Boehmer, H., Kisielow, P. 1990. Self-nonself discrimination by T cells. Science 248: 1369-73
    • (1990) Science , vol.248 , pp. 1369-1373
    • Von Boehmer, H.1    Kisielow, P.2
  • 96
    • 0024523366 scopus 로고
    • Isotype exclusion and transgene down-regulation in immunoglobulin-λ transgenic mice
    • Neuberger, M. S., Caskey, H. M., Pettersson, S., Williams, G. T., Surani, M. A. 1989. Isotype exclusion and transgene down-regulation in immunoglobulin-λ transgenic mice. Nature 338: 350-52
    • (1989) Nature , vol.338 , pp. 350-352
    • Neuberger, M.S.1    Caskey, H.M.2    Pettersson, S.3    Williams, G.T.4    Surani, M.A.5
  • 98
    • 0019293065 scopus 로고
    • Transcripts of the immunoglobulin Cμ gene vary in structure and splicing during lymphoid development
    • Kemp, D., Harris, A. W., Adams, J. M. 1980. Transcripts of the immunoglobulin Cμ gene vary in structure and splicing during lymphoid development. Proc. Natl. Acad. Sci. USA 77: 7400-4
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 7400-7404
    • Kemp, D.1    Harris, A.W.2    Adams, J.M.3
  • 99
    • 0024384379 scopus 로고
    • Alteration of the B cell surface phenotype, immune response to phosphocholine, and the B cell repertoire in M167 μ plus κ transgenic mice
    • Kenny, J. J., Finkelman, F., Macchiarini, F., Kopp, W. C., Storb, U., Longo, D. L. 1989. Alteration of the B cell surface phenotype, immune response to phosphocholine, and the B cell repertoire in M167 μ plus κ transgenic mice. J. Immunol. 142: 4466-74
    • (1989) J. Immunol. , vol.142 , pp. 4466-4474
    • Kenny, J.J.1    Finkelman, F.2    Macchiarini, F.3    Kopp, W.C.4    Storb, U.5    Longo, D.L.6
  • 102
    • 85084623955 scopus 로고
    • Development and follicular localization of tolerant B lymphocytes in lysozyme/antilysozyme IgM/IgD transgenic mice
    • In press
    • Mason, D. Y., Jones, M., Goodnow, C. C. 1991. Development and follicular localization of tolerant B lymphocytes in lysozyme/antilysozyme IgM/IgD transgenic mice. Int. Immunol. In press
    • (1991) Int. Immunol.
    • Mason, D.Y.1    Jones, M.2    Goodnow, C.C.3
  • 104
    • 0026019627 scopus 로고
    • Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin
    • Era, T., Ogawa, M., Nishikawa, S.-I., Okamoto, M., Honjo, T., Akagi, K., Miyazaki, J.-I., Yamamura, K.-I. 1991. Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin. EMBO J. 10: 337-42
    • (1991) EMBO J. , vol.10 , pp. 337-342
    • Era, T.1    Ogawa, M.2    Nishikawa, S.-I.3    Okamoto, M.4    Honjo, T.5    Akagi, K.6    Miyazaki, J.-I.7    Yamamura, K.-I.8
  • 105
    • 0024529870 scopus 로고
    • Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes
    • Nemazee, D. A., Bürki, K. 1989. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 337: 562-66
    • (1989) Nature , vol.337 , pp. 562-566
    • Nemazee, D.A.1    Bürki, K.2
  • 106
    • 0023694520 scopus 로고
    • Rearrangement and expression of endogenous immunoglobulin genes occur in many murine B cells expressing transgenic membrane IgM
    • Stall, A. M., Kroese, F. G. M., Gadus, F. T., Sieckmann, D. G., Herzenberg, L. A., Herzenberg, L. A. 1988. Rearrangement and expression of endogenous immunoglobulin genes occur in many murine B cells expressing transgenic membrane IgM. Proc. Natl. Acad. Sci. USA 85: 3546-50
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 3546-3550
    • Stall, A.M.1    Kroese, F.G.M.2    Gadus, F.T.3    Sieckmann, D.G.4    Herzenberg, L.A.5    Herzenberg, L.A.6
  • 107
    • 0024464116 scopus 로고
    • Cellular selection leads to age-dependent and reversible downregulation of transgenic immunoglobulin light chain genes
    • Pettersson, S., Sharpe, M. J., Gilmore, D. R., Surani, M. A., Neuberger, M. S. 1989. Cellular selection leads to age-dependent and reversible downregulation of transgenic immunoglobulin light chain genes. Int. Immunol. 1: 509
    • (1989) Int. Immunol. , vol.1 , pp. 509
    • Pettersson, S.1    Sharpe, M.J.2    Gilmore, D.R.3    Surani, M.A.4    Neuberger, M.S.5
  • 109
    • 0023902072 scopus 로고
    • T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous α-and β-genes
    • Bluthmann, H., Kisielow, P., Uematsu, Y., Malissen, M., Krimpenfort, P., Berns, A., von Boehmer, H., Steinmetz, M. 1988. T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous α-and β-genes. Nature 334: 156-59
    • (1988) Nature , vol.334 , pp. 156-159
    • Bluthmann, H.1    Kisielow, P.2    Uematsu, Y.3    Malissen, M.4    Krimpenfort, P.5    Berns, A.6    Von Boehmer, H.7    Steinmetz, M.8
  • 110
    • 0025948793 scopus 로고
    • Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens
    • Hartley, S. B., Crosbie, J., Brink, R. A., Kantor, A. B., Basten, A., Goodnow, C. C. 1991. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature 353: 765-69
    • (1991) Nature , vol.353 , pp. 765-769
    • Hartley, S.B.1    Crosbie, J.2    Brink, R.A.3    Kantor, A.B.4    Basten, A.5    Goodnow, C.C.6
  • 113
    • 0025338518 scopus 로고
    • Selective peripheral expansion and activation of B cells expressing endogenous immunoglobulin in μ-transgenic mice
    • Grandien, A., Coutinho, A., Andersson, J. 1990. Selective peripheral expansion and activation of B cells expressing endogenous immunoglobulin in μ-transgenic mice. Eur. J. Immunol. 20: 991-98
    • (1990) Eur. J. Immunol. , vol.20 , pp. 991-998
    • Grandien, A.1    Coutinho, A.2    Andersson, J.3
  • 114
    • 0025323890 scopus 로고
    • Extensive splenic B cell activation in IgM-transgenic mice
    • Forni, L. 1990. Extensive splenic B cell activation in IgM-transgenic mice. Eur. J. Immunol. 20: 983-89
    • (1990) Eur. J. Immunol. , vol.20 , pp. 983-989
    • Forni, L.1
  • 115
    • 0024415591 scopus 로고
    • Quantitative analysis of idiotypic mimicry and allelic exclusion in mice with a μ Ig transgene
    • Rath, S., Durdik, J., Gerstein, R. M., Selsing, E., Nisonoff, A. 1989. Quantitative analysis of idiotypic mimicry and allelic exclusion in mice with a μ Ig transgene. J. Immunol. 143: 2074-80
    • (1989) J. Immunol. , vol.143 , pp. 2074-2080
    • Rath, S.1    Durdik, J.2    Gerstein, R.M.3    Selsing, E.4    Nisonoff, A.5
  • 116
    • 0025980973 scopus 로고
    • Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice
    • Erikson, J., Radic, M. Z., Camper, S. A., Hardy, R. R., Carmack, C., Weigert, M. 1991. Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature 349: 331-34
    • (1991) Nature , vol.349 , pp. 331-334
    • Erikson, J.1    Radic, M.Z.2    Camper, S.A.3    Hardy, R.R.4    Carmack, C.5    Weigert, M.6
  • 117
    • 85084622489 scopus 로고
    • Submitted; personal communication
    • Okamoto, M., Honjo, T. 1992. Submitted; personal communication
    • (1992)
    • Okamoto, M.1    Honjo, T.2
  • 118
    • 0024455288 scopus 로고
    • Induction of self-tolerance in mature peripheral B lymphocytes
    • Goodnow, C. C., Crosbie, J., Jorgensen, H., Brink, R. A., Basten, A. 1989. Induction of self-tolerance in mature peripheral B lymphocytes. Nature 342: 385-91
    • (1989) Nature , vol.342 , pp. 385-391
    • Goodnow, C.C.1    Crosbie, J.2    Jorgensen, H.3    Brink, R.A.4    Basten, A.5
  • 120
    • 0024514560 scopus 로고
    • Human insulin autoantibody fine specificity and H and L chain use
    • Nell, L. J., Hulbert, C., Thomas, J. W. 1989. Human insulin autoantibody fine specificity and H and L chain use. J. Immunol. 142: 3063-69
    • (1989) J. Immunol. , vol.142 , pp. 3063-3069
    • Nell, L.J.1    Hulbert, C.2    Thomas, J.W.3
  • 121
    • 0024504877 scopus 로고
    • Receptor and antibody epitopes in human growth hormone identified by homolog-scanning mutagenesis
    • Cunningham, B. C., Jhurani, P., Ng, P., Wells, J. A. 1989. Receptor and antibody epitopes in human growth hormone identified by homolog-scanning mutagenesis. Science 243: 1330-36
    • (1989) Science , vol.243 , pp. 1330-1336
    • Cunningham, B.C.1    Jhurani, P.2    Ng, P.3    Wells, J.A.4
  • 122
    • 0019287085 scopus 로고
    • Analysis of autoimmunity through experimental models of thyroiditis and allergic encephalomyelitis
    • Weigle, W. O. 1980. Analysis of autoimmunity through experimental models of thyroiditis and allergic encephalomyelitis. Adv. Immunol. 30: 159-253
    • (1980) Adv. Immunol. , vol.30 , pp. 159-253
    • Weigle, W.O.1
  • 123
    • 0023108381 scopus 로고
    • Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells
    • Adams, T. E., Alpert, S., Hanahan, D. 1987. Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells. Nature 325: 223-38
    • (1987) Nature , vol.325 , pp. 223-238
    • Adams, T.E.1    Alpert, S.2    Hanahan, D.3
  • 124
    • 0025161357 scopus 로고
    • A peripheral mechanism preserves self-tolerance to a secreted protein in transgenic mice
    • Whiteley, P. J., Poindexter, N. J., Landon, C., Kapp, J. A. 1990. A peripheral mechanism preserves self-tolerance to a secreted protein in transgenic mice. J. Immunol. 145: 1376-81
    • (1990) J. Immunol. , vol.145 , pp. 1376-1381
    • Whiteley, P.J.1    Poindexter, N.J.2    Landon, C.3    Kapp, J.A.4
  • 126
    • 0020573342 scopus 로고
    • Induction of rheumatoid antibodies in the mouse
    • Nemazee, D. A., Sato, V. L. 1983. Induction of rheumatoid antibodies in the mouse. J. Exp. Med. 158: 529-45
    • (1983) J. Exp. Med. , vol.158 , pp. 529-545
    • Nemazee, D.A.1    Sato, V.L.2
  • 128
    • 0025351749 scopus 로고
    • Intrinsic B-cell hyporesponsiveness accounts for self-tolerance in lysozyrne/antilysozyme double-transgenic mice
    • Adams, E., Basten, A., Goodnow, C. C. 1990. Intrinsic B-cell hyporesponsiveness accounts for self-tolerance in lysozyrne/antilysozyme double-transgenic mice. Proc. Natl. Acad. Sci. USA 87: 5687-91
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 5687-5691
    • Adams, E.1    Basten, A.2    Goodnow, C.C.3
  • 129
    • 0025812171 scopus 로고
    • Breakdown of self-tolerance in anergic B lymphocytes
    • Goodnow, C. C., Brink, R. A., Adams, E. 1991. Breakdown of self-tolerance in anergic B lymphocytes. Nature 352: 532-36
    • (1991) Nature , vol.352 , pp. 532-536
    • Goodnow, C.C.1    Brink, R.A.2    Adams, E.3
  • 130
    • 0004776313 scopus 로고
    • Ligand-induced desensitization of B cell membrane immunoglobulin-mediated Ca2+ mobilization and protein kinase C translocation
    • Cambier, J., Chen, Z.-Z., Pasternak, J., Ransom, J., Sandoval, V., Pickles, H. 1988. Ligand-induced desensitization of B cell membrane immunoglobulin-mediated Ca2+ mobilization and protein kinase C translocation. Proc. Natl. Acad. Sci. USA 85: 6493-97
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 6493-6497
    • Cambier, J.1    Chen, Z.-Z.2    Pasternak, J.3    Ransom, J.4    Sandoval, V.5    Pickles, H.6
  • 131
    • 0025362099 scopus 로고
    • Dual molecular mechanisms mediate ligand-induced membrane Ig desensitization
    • Cambier, J. C., Fisher, C. L., Pickles, H., Morrison, D. C. 1990. Dual molecular mechanisms mediate ligand-induced membrane Ig desensitization. J. Immunol. 145: 13-19
    • (1990) J. Immunol. , vol.145 , pp. 13-19
    • Cambier, J.C.1    Fisher, C.L.2    Pickles, H.3    Morrison, D.C.4
  • 132
    • 0022374275 scopus 로고
    • Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model
    • Sibley, D. R., Lefkowitz, R. J. 1985. Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model. Nature 317: 124-29
    • (1985) Nature , vol.317 , pp. 124-129
    • Sibley, D.R.1    Lefkowitz, R.J.2
  • 133
    • 0020628152 scopus 로고
    • Tolerance of T-cell clones is associated with membrane antigen changes
    • Zanders, E. D., Lamb, J. R., Feldmann, M., Green, N., Beverley, P. C. L. 1983. Tolerance of T-cell clones is associated with membrane antigen changes. Nature 303: 625-27
    • (1983) Nature , vol.303 , pp. 625-627
    • Zanders, E.D.1    Lamb, J.R.2    Feldmann, M.3    Green, N.4    Beverley, P.C.L.5
  • 134
    • 0025908321 scopus 로고
    • Peripheral selection of the T cell repertoire
    • Rocha, B., von Boehmer, H. 1991. Peripheral selection of the T cell repertoire. Science 251: 1225-28
    • (1991) Science , vol.251 , pp. 1225-1228
    • Rocha, B.1    Von Boehmer, H.2
  • 135
  • 136
    • 0025339511 scopus 로고
    • A cell culture model for T lymphocyte clonal anergy
    • Schwartz, R. H. 1990. A cell culture model for T lymphocyte clonal anergy. Science 248: 1349-56
    • (1990) Science , vol.248 , pp. 1349-1356
    • Schwartz, R.H.1
  • 137
    • 0024338344 scopus 로고
    • Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-Ib mice with Mls-Ia expressing cells
    • Rammensee, H.-G., Kroschewski, R., Frangoulis, B. 1989. Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-Ib mice with Mls-Ia expressing cells. Nature 339: 541-44
    • (1989) Nature , vol.339 , pp. 541-544
    • Rammensee, H.-G.1    Kroschewski, R.2    Frangoulis, B.3
  • 138
    • 0024381358 scopus 로고
    • A nondeletional mechanism of thymic self tolerance
    • Ramsdell, F., Lantz, T., Fowlkes, B. J. 1989. A nondeletional mechanism of thymic self tolerance. Science 246: 1038-41
    • (1989) Science , vol.246 , pp. 1038-1041
    • Ramsdell, F.1    Lantz, T.2    Fowlkes, B.J.3
  • 140
    • 0023279398 scopus 로고
    • Molecular basis for the inhibition of LPS induced differentiation by anti-immunoglobulin
    • Yuan, D. 1987. Molecular basis for the inhibition of LPS induced differentiation by anti-immunoglobulin. J. Mol. Cell. Immunol. 3: 133-44
    • (1987) J. Mol. Cell. Immunol. , vol.3 , pp. 133-144
    • Yuan, D.1
  • 141
    • 0023390431 scopus 로고
    • Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones
    • Jenkins, M. K., Pardoll, D. M., Mizuguchi, J., Chused, T. M., Schwartz, R. H. 1987. Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones. Proc. Natl. Acad. Sci. USA 84: 5409-13
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 5409-5413
    • Jenkins, M.K.1    Pardoll, D.M.2    Mizuguchi, J.3    Chused, T.M.4    Schwartz, R.H.5
  • 142
    • 0023143676 scopus 로고
    • Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
    • Jenkins, M. K., Schwartz, R. H. 1987. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165: 302-19
    • (1987) J. Exp. Med. , vol.165 , pp. 302-319
    • Jenkins, M.K.1    Schwartz, R.H.2
  • 143
    • 0009927162 scopus 로고
    • Clonal deletion of autoreactive B lymphocytes in bone marrow chimaeras
    • Nemazee, D., Buerki, K. 1989. Clonal deletion of autoreactive B lymphocytes in bone marrow chimaeras. Proc. Natl. Acad. Sci. USA 86: 8039-43
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 8039-8043
    • Nemazee, D.1    Buerki, K.2
  • 144
    • 0019205672 scopus 로고
    • An immunological suppressor cell inactivating cytotoxic T-lymphocyte precursor cells recognizing it
    • Miller, R. G. 1980. An immunological suppressor cell inactivating cytotoxic T-lymphocyte precursor cells recognizing it. Nature 287: 544-46
    • (1980) Nature , vol.287 , pp. 544-546
    • Miller, R.G.1
  • 145
  • 146
    • 0024492086 scopus 로고
    • Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures
    • Smith, C. A., Williams, G. T., Kingston, R., Jenkinson, E. J., Owen, J. J. T. 1989. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature 337: 181-84
    • (1989) Nature , vol.337 , pp. 181-184
    • Smith, C.A.1    Williams, G.T.2    Kingston, R.3    Jenkinson, E.J.4    Owen, J.J.T.5
  • 147
    • 0025697469 scopus 로고
    • Induction by antigen of intrathymic apoptosis of CD4+ CD8+ TCRIo thymocytes in vivo
    • Murphy, K. M., Heimberger, A. B., Loh, D. Y. 1990. Induction by antigen of intrathymic apoptosis of CD4+ CD8+ TCRIo thymocytes in vivo. Science 250: 1720-23
    • (1990) Science , vol.250 , pp. 1720-1723
    • Murphy, K.M.1    Heimberger, A.B.2    Loh, D.Y.3
  • 149
    • 0023786047 scopus 로고
    • Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
    • Vaux, D. L., Cory, S., Adams, J. M. 1988. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335: 440-42
    • (1988) Nature , vol.335 , pp. 440-442
    • Vaux, D.L.1    Cory, S.2    Adams, J.M.3
  • 150
    • 0025091773 scopus 로고
    • Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis
    • Williams, G. T., Smith, C. A., Spooncer, E., Dexter, T. M., Taylor, D. R. 1990. Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature 343: 76-79
    • (1990) Nature , vol.343 , pp. 76-79
    • Williams, G.T.1    Smith, C.A.2    Spooncer, E.3    Dexter, T.M.4    Taylor, D.R.5
  • 151
    • 0021309472 scopus 로고
    • Cell death in invertebrate nervous systems
    • Truman, J. W. 1984. Cell death in invertebrate nervous systems. Annu. Rev. Neurosci. 7: 171-88
    • (1984) Annu. Rev. Neurosci. , vol.7 , pp. 171-188
    • Truman, J.W.1
  • 154
    • 0016371903 scopus 로고
    • Paralysis to serum albumins in T and B lymphocytes in mice. Dose depen dence, specificity, and kinetics of escape
    • Rajewsky, K., Brenig, C. 1974. Paralysis to serum albumins in T and B lymphocytes in mice. Dose depen dence, specificity, and kinetics of escape. Eur. J. Immunol. 4: 120-25
    • (1974) Eur. J. Immunol. , vol.4 , pp. 120-125
    • Rajewsky, K.1    Brenig, C.2
  • 155
    • 0023024754 scopus 로고
    • Allosteric regulation of the epidermal growth factor receptor kinase
    • Schlessinger, J. 1986. Allosteric regulation of the epidermal growth factor receptor kinase. J. Cell Biol. 103: 2067-72
    • (1986) J. Cell Biol. , vol.103 , pp. 2067-2072
    • Schlessinger, J.1
  • 156
    • 0024521844 scopus 로고
    • Signal transduction by the platelet-derived growth factor receptor
    • Williams, L. T. 1989. Signal transduction by the platelet-derived growth factor receptor. Science 243: 1564-70
    • (1989) Science , vol.243 , pp. 1564-1570
    • Williams, L.T.1
  • 157
    • 0025765803 scopus 로고
    • SH2 and SH3 domains: Elements that control interactions of cytoplasmic signaling proteins
    • Koch, A. E., Anderson, D., Moran, M. F., Ellis, C., Pawson, T. 1991. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science 252: 668-74
    • (1991) Science , vol.252 , pp. 668-674
    • Koch, A.E.1    Anderson, D.2    Moran, M.F.3    Ellis, C.4    Pawson, T.5
  • 158
    • 0025972582 scopus 로고
    • Association of B cell antigen receptor with protein tyrosine kinase lyn
    • Yamanashi, Y., Kakiuchi, T., Mizuguchi, J., Yamamoto, T., Toyoshima, K. 1991. Association of B cell antigen receptor with protein tyrosine kinase lyn. Science 251: 192-94
    • (1991) Science , vol.251 , pp. 192-194
    • Yamanashi, Y.1    Kakiuchi, T.2    Mizuguchi, J.3    Yamamoto, T.4    Toyoshima, K.5
  • 159
  • 160
    • 0025332477 scopus 로고
    • T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation
    • Mustelin, T., Coggeshall, K. M., Isakov, N., Altman, A. 1990. T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation. Science 247: 1584-87
    • (1990) Science , vol.247 , pp. 1584-1587
    • Mustelin, T.1    Coggeshall, K.M.2    Isakov, N.3    Altman, A.4
  • 162
    • 0025752347 scopus 로고
    • Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)
    • Cooke, M. P., Abraham, K. M., Forbush, K. A., Perlmutter, R. M. 1991. Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn). Cell 65: 281-91
    • (1991) Cell , vol.65 , pp. 281-291
    • Cooke, M.P.1    Abraham, K.M.2    Forbush, K.A.3    Perlmutter, R.M.4
  • 163
    • 0025898888 scopus 로고
    • Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45
    • Justement, L. B., Campbell, K. S., Chien, N. C., Cambier, J. C. 1991. Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45. Science 252: 1839-42
    • (1991) Science , vol.252 , pp. 1839-1842
    • Justement, L.B.1    Campbell, K.S.2    Chien, N.C.3    Cambier, J.C.4
  • 164
    • 0025849698 scopus 로고
    • Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes
    • Carter, R. H., Park, D. J., Rhee, S. G., Fearon, D. T. 1991. Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes. Proc. Natl. Acad. Sci. USA 88: 2745-49
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 2745-2749
    • Carter, R.H.1    Park, D.J.2    Rhee, S.G.3    Fearon, D.T.4
  • 165
    • 0023811099 scopus 로고
    • G protein regulation of receptor signalling
    • Harnett, M. M., Klaus, G. G. B. 1988. G protein regulation of receptor signalling. Immunol. Today 9: 315-20
    • (1988) Immunol. Today , vol.9 , pp. 315-320
    • Harnett, M.M.1    Klaus, G.G.B.2
  • 166
    • 0023082152 scopus 로고
    • Molecular mechanisms of transmembrane signaling in B lymphocytes
    • Gambier, J. C., Ransom, J. T. 1987. Molecular mechanisms of transmembrane signaling in B lymphocytes. Annu. Rev. Immunol. 5: 175-99
    • (1987) Annu. Rev. Immunol. , vol.5 , pp. 175-199
    • Gambier, J.C.1    Ransom, J.T.2
  • 167
    • 0023492340 scopus 로고
    • Molecular aspects of B-lymphocyte activation
    • DeFranco, A. L. 1987. Molecular aspects of B-lymphocyte activation. Annu. Rev. Cell Biol. 3: 143-78
    • (1987) Annu. Rev. Cell Biol. , vol.3 , pp. 143-178
    • DeFranco, A.L.1
  • 169
    • 0022519337 scopus 로고
    • Three-dimensional structure of an antigen-antibody complex at 2.8 a resolution
    • Amit, A. G., Mariuzza, R. A., Phillips, S. E. V., Poljak, R. J. 1986. Three-dimensional structure of an antigen-antibody complex at 2.8 A resolution. Science 233: 747-53
    • (1986) Science , vol.233 , pp. 747-753
    • Amit, A.G.1    Mariuzza, R.A.2    Phillips, S.E.V.3    Poljak, R.J.4
  • 172
  • 173
    • 0017725175 scopus 로고
    • Ontogeny of B-lymphocyte function. III. in vivo and in vitro studies on the ease of tolerance induction in B lymphocytes from fetal, neonatal, and adult mice
    • Szewczuk, M. R., Siskind, G. W. 1977. Ontogeny of B-lymphocyte function. III. In vivo and in vitro studies on the ease of tolerance induction in B lymphocytes from fetal, neonatal, and adult mice. J. Exp. Med. 145: 1590
    • (1977) J. Exp. Med. , vol.145 , pp. 1590
    • Szewczuk, M.R.1    Siskind, G.W.2
  • 174
    • 0023727485 scopus 로고
    • Anti-IgM-mediated B cell signalling: Molecular analysis of ligand binding requisites for human B cell clonal expansion and tolerance
    • Rudich, S. M., Roux, K. H., Winchester, R. J., Mongini, P. K. A. 1988. Anti-IgM-mediated B cell signalling: Molecular analysis of ligand binding requisites for human B cell clonal expansion and tolerance. J. Exp. Med. 168: 247-66
    • (1988) J. Exp. Med. , vol.168 , pp. 247-266
    • Rudich, S.M.1    Roux, K.H.2    Winchester, R.J.3    Mongini, P.K.A.4
  • 176
    • 0020546049 scopus 로고
    • Studies on the immunogenicity and tolerogenicity of T-independent antigens
    • Dintzis, R. Z., Middleton, M. H., Dintzis, H. M. 1983. Studies on the immunogenicity and tolerogenicity of T-independent antigens. J. Immunol. 131: 2196-2203
    • (1983) J. Immunol. , vol.131 , pp. 2196-2203
    • Dintzis, R.Z.1    Middleton, M.H.2    Dintzis, H.M.3
  • 177
    • 0024395440 scopus 로고
    • The immunogenicity of soluble haptenated polymers is determined by molecular mass and hapten valence
    • Dintzis, R. Z., Okajima, M., Middleton, M. H., Greene, G., Dintzis, H. M. 1989. The immunogenicity of soluble haptenated polymers is determined by molecular mass and hapten valence. J. Immunol. 143: 1239-44
    • (1989) J. Immunol. , vol.143 , pp. 1239-1244
    • Dintzis, R.Z.1    Okajima, M.2    Middleton, M.H.3    Greene, G.4    Dintzis, H.M.5
  • 178
    • 0025221021 scopus 로고
    • Methyl ation of an immediate-early inducible gene as a mechanism for B cell tolerance induction
    • Seyfert, V. L., McMahon, S. B., Glenn, W. D., Yellen, A. J., Sukhatme, V. P., Cao, X., Monroe, J. G. 1990. Methyl ation of an immediate-early inducible gene as a mechanism for B cell tolerance induction. Science 250: 797-800
    • (1990) Science , vol.250 , pp. 797-800
    • Seyfert, V.L.1    McMahon, S.B.2    Glenn, W.D.3    Yellen, A.J.4    Sukhatme, V.P.5    Cao, X.6    Monroe, J.G.7
  • 179
    • 0025971175 scopus 로고
    • Signaling through surface IgM in tolerance-susceptible immature murine B lymphocytes. Developmentally regulated difference in transmembrane signaling in splenic B cells from adult and neonatal mice
    • Yellen, A. J., Glenn, W., Sukhatme, V. P., Cao, S. M., Monroe, J. G. 1991. Signaling through surface IgM in tolerance-susceptible immature murine B lymphocytes. Developmentally regulated difference in transmembrane signaling in splenic B cells from adult and neonatal mice. J. Immunol. 146: 1446-54
    • (1991) J. Immunol. , vol.146 , pp. 1446-1454
    • Yellen, A.J.1    Glenn, W.2    Sukhatme, V.P.3    Cao, S.M.4    Monroe, J.G.5
  • 180
    • 0023887424 scopus 로고
    • Picogram quantities of anti-Ig antibodies coupled to dextran induce B cell proliferation
    • Brunswick, M., Finkelman, F. D., Highet, P. F., Inman, J. K., Dintzis, H. M., Mond, J. J. 1988. Picogram quantities of anti-Ig antibodies coupled to dextran induce B cell proliferation. J. Immunol. 140: 3364-72
    • (1988) J. Immunol. , vol.140 , pp. 3364-3372
    • Brunswick, M.1    Finkelman, F.D.2    Highet, P.F.3    Inman, J.K.4    Dintzis, H.M.5    Mond, J.J.6
  • 181
    • 0026052840 scopus 로고
    • Tolerance susceptibility of newly generating memory B cells
    • Linton, P. J., Rudie, A., Klinman, N. R. 1991. Tolerance susceptibility of newly generating memory B cells. J. Immunol. 146: 4099-4104
    • (1991) J. Immunol. , vol.146 , pp. 4099-4104
    • Linton, P.J.1    Rudie, A.2    Klinman, N.R.3
  • 182
    • 0025368647 scopus 로고
    • The need for central and peripheral tolerance in the B cell repertoire
    • Goodnow, C. C., Adelstein, S., Basten, A. 1990. The need for central and peripheral tolerance in the B cell repertoire. Science 248: 1373-79
    • (1990) Science , vol.248 , pp. 1373-1379
    • Goodnow, C.C.1    Adelstein, S.2    Basten, A.3
  • 183
    • 0015140466 scopus 로고
    • Nonantigenicity and immunologic tolerance: The role of the carrier in the induction of tolerance to the hapten
    • Golan, D. T., Borel, Y. 1971. Nonantigenicity and immunologic tolerance: the role of the carrier in the induction of tolerance to the hapten. J. Exp. Med. 134: 1046-60
    • (1971) J. Exp. Med. , vol.134 , pp. 1046-1060
    • Golan, D.T.1    Borel, Y.2
  • 184
    • 0014941660 scopus 로고
    • Tolerance induction by an apparently non-immunogenic molecule
    • Roelants, G. E., Goodman, J. W. 1970. Tolerance induction by an apparently non-immunogenic molecule. Nature 227: 175-76
    • (1970) Nature , vol.227 , pp. 175-176
    • Roelants, G.E.1    Goodman, J.W.2
  • 185
    • 0014095393 scopus 로고
    • Studies on the induction of immunologic unresponsiveness I. Effects of endotoxin and phytohemagglutinin
    • Golub, E. S., Weigle, W. O. 1967. Studies on the induction of immunologic unresponsiveness I. Effects of endotoxin and phytohemagglutinin. J. Immunol. 98: 1241-47
    • (1967) J. Immunol. , vol.98 , pp. 1241-1247
    • Golub, E.S.1    Weigle, W.O.2
  • 187
    • 0025875258 scopus 로고
    • Regulation of human B-cell activation and adhesion
    • Clark, E. A., Lane, P. J. L. 1991. Regulation of human B-cell activation and adhesion. Annu. Rev. Immunol. 9: 97-127
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 97-127
    • Clark, E.A.1    Lane, P.J.L.2
  • 189
    • 0025910406 scopus 로고
    • Between B cells and T cells
    • DeFranco, A. L. 1991. Between B cells and T cells. Nature 351: 604
    • (1991) Nature , vol.351 , pp. 604
    • DeFranco, A.L.1
  • 190
    • 0022388544 scopus 로고
    • Growth control of activated, synchronized murine B cells by the C3d fragment of human complement
    • Melchers, F., Erdei, A., Schulz, T., Dierich, M. 1985. Growth control of activated, synchronized murine B cells by the C3d fragment of human complement. Nature 317: 264-67
    • (1985) Nature , vol.317 , pp. 264-267
    • Melchers, F.1    Erdei, A.2    Schulz, T.3    Dierich, M.4
  • 191
    • 0025350184 scopus 로고
    • Monovalent ligands of complement receptor 2 inhibit whereas polyvalent ligands enhance anti-Ig-induced human B cell intracytoplasmic free calcium concentration
    • Tsokos, G. C., Lambris, J. D., Finkelman, F. D., Anastossiou, E. D., June, C. H. 1990. Monovalent ligands of complement receptor 2 inhibit whereas polyvalent ligands enhance anti-Ig-induced human B cell intracytoplasmic free calcium concentration. J. Immunol. 144: 1640-45
    • (1990) J. Immunol. , vol.144 , pp. 1640-1645
    • Tsokos, G.C.1    Lambris, J.D.2    Finkelman, F.D.3    Anastossiou, E.D.4    June, C.H.5
  • 192
    • 0024518069 scopus 로고
    • Co-cross-linking of surface immunoglobulin Fcγ receptors in B lymphocytes uncouples the antigen receptors from their associated G protein
    • Rigley, K. P., Harnett, M. M., Klaus, G. G. B. 1989. Co-cross-linking of surface immunoglobulin Fcγ receptors in B lymphocytes uncouples the antigen receptors from their associated G protein. Eur. J. Immunol. 19: 481-85
    • (1989) Eur. J. Immunol. , vol.19 , pp. 481-485
    • Rigley, K.P.1    Harnett, M.M.2    Klaus, G.G.B.3
  • 193
    • 0021965499 scopus 로고
    • Follicular dendritic cells in suspension: Identification, enrichment, and initial characterization indicating immune complex trapping and lack of adherence and phagocytic activity
    • Schnizlein, C. T., Kosco, M. H., Szakal, A. K., Tew, J. G. 1985. Follicular dendritic cells in suspension: identification, enrichment, and initial characterization indicating immune complex trapping and lack of adherence and phagocytic activity. J. Immunol. 134: 1360-68
    • (1985) J. Immunol. , vol.134 , pp. 1360-1368
    • Schnizlein, C.T.1    Kosco, M.H.2    Szakal, A.K.3    Tew, J.G.4
  • 194
    • 0023821895 scopus 로고
    • The dynamic nature of the antibody repertoire
    • Berek, C., Milstein, C. 1988. The dynamic nature of the antibody repertoire. Immunol. Rev. 105: 5-26
    • (1988) Immunol. Rev. , vol.105 , pp. 5-26
    • Berek, C.1    Milstein, C.2
  • 195
    • 0023510298 scopus 로고
    • Evolutionary and somatic selection of the antibody repertoire in the mouse
    • Rajewsky, K., Forster, I., Cumano, A. 1987. Evolutionary and somatic selection of the antibody repertoire in the mouse. Science 238: 1088-94
    • (1987) Science , vol.238 , pp. 1088-1094
    • Rajewsky, K.1    Forster, I.2    Cumano, A.3
  • 196
    • 0024362047 scopus 로고
    • The role of somatic hypermutation in the generation of antibody diversity
    • French, D. L., Laskov, R., Scharff, M. D. 1989. The role of somatic hypermutation in the generation of antibody diversity. Science 244: 1152-57
    • (1989) Science , vol.244 , pp. 1152-1157
    • French, D.L.1    Laskov, R.2    Scharff, M.D.3
  • 198
    • 0023204355 scopus 로고
    • Systemic autoimmune disease arises from polyclonal B cell activation
    • Klinman, D. M., Steinberg, A. D. 1987. Systemic autoimmune disease arises from polyclonal B cell activation. J. Exp. Med. 165: 1755-60
    • (1987) J. Exp. Med. , vol.165 , pp. 1755-1760
    • Klinman, D.M.1    Steinberg, A.D.2
  • 199
    • 0017704089 scopus 로고
    • Features of systemic lupus erythematosus in mice injected with bacterial lipopolysaccharides. Identification of circulating DNA and renal localization of DNA-anti-DNA complexes
    • Izui, S., Lambert, P. H., Fournie, G., Turler, H., Miescher, P. A. 1977. Features of systemic lupus erythematosus in mice injected with bacterial lipopolysaccharides. Identification of circulating DNA and renal localization of DNA-anti-DNA complexes. J. Exp. Med. 145: 1115
    • (1977) J. Exp. Med. , vol.145 , pp. 1115
    • Izui, S.1    Lambert, P.H.2    Fournie, G.3    Turler, H.4    Miescher, P.A.5
  • 201
    • 0017039327 scopus 로고
    • Diseases caused by reactions of T lymphocytes to incompatible structures of the major histocompatibility complex
    • Gleichmann, E., Gleichmann, H. 1976. Diseases caused by reactions of T lymphocytes to incompatible structures of the major histocompatibility complex. Eur. J. Immunol. 6: 899-906
    • (1976) Eur. J. Immunol. , vol.6 , pp. 899-906
    • Gleichmann, E.1    Gleichmann, H.2
  • 202
    • 0020082244 scopus 로고
    • A systemic lupus erythematosus (SLE)-like disease in mice induced by abnormal T-B cell cooperation. Preferential formation of autoantibodies characteristic of SLE
    • Gleichmann, E., Van Elven, E. H., Van der Veen, J. P. W. 1982. A systemic lupus erythematosus (SLE)-like disease in mice induced by abnormal T-B cell cooperation. Preferential formation of autoantibodies characteristic of SLE. Eur. J. Immunol. 12: 152-59
    • (1982) Eur. J. Immunol. , vol.12 , pp. 152-159
    • Gleichmann, E.1    Van Elven, E.H.2    Van Der Veen, J.P.W.3
  • 203
    • 0019395395 scopus 로고
    • Rat erythrocyte-induced anti-erythrocyte autoantibody production and control in normal mice
    • Naysmith, J. D., Ortega-Pierres, M. G., Elson, C. J. 1981. Rat erythrocyte-induced anti-erythrocyte autoantibody production and control in normal mice. Immunol. Rev. 55: 55-87
    • (1981) Immunol. Rev. , vol.55 , pp. 55-87
    • Naysmith, J.D.1    Ortega-Pierres, M.G.2    Elson, C.J.3
  • 204
    • 0025875259 scopus 로고
    • Lpr and gld: Single gene models of systemic autoimmunity and lymphoproliferative disease
    • Cohen, P. L., Eisenberg, R. A. 1991. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9: 243-69
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 243-269
    • Cohen, P.L.1    Eisenberg, R.A.2
  • 205
    • 0024444922 scopus 로고
    • Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse
    • Forster, I., Vieira, P., Rajewsky, K. 1989. Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse. Int. Immunol. 1: 321-31
    • (1989) Int. Immunol. , vol.1 , pp. 321-331
    • Forster, I.1    Vieira, P.2    Rajewsky, K.3
  • 206
    • 0025868702 scopus 로고
    • Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
    • Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D., Hayakawa, K. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173: 1213-25
    • (1991) J. Exp. Med. , vol.173 , pp. 1213-1225
    • Hardy, R.R.1    Carmack, C.E.2    Shinton, S.A.3    Kemp, J.D.4    Hayakawa, K.5


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