Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia

Genes and Development

Volumn 6, Issue 9, 1992, Pages 1608-1620

  Hunger, Stephen P ^a   Ohyashiki, Kazuma ^b   Toyama, Keisuke ^b   Cleary, Michael L ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

BZIP protein; Chimeric protein; Chromosomal translocation; HLH protein; Oncogenel; Transcription factor

Indexed keywords

ERAGROSTIS TEF; RICKETTSIA SP. PAR;

DNA; GENE PRODUCT; HYBRID PROTEIN; LIVER PROTEIN; TRANSCRIPTION FACTOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; AMINO TERMINAL SEQUENCE; ARTICLE; CHROMOSOME TRANSLOCATION; DIMERIZATION; DNA BINDING; GENE FUSION; GENETIC REGULATION; HUMAN; HUMAN CELL; LEUKEMOGENESIS; MALIGNANT TRANSFORMATION; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN ANALYSIS; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; BASE SEQUENCE; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; CHROMOSOMES, HUMAN, PAIR 17; CHROMOSOMES, HUMAN, PAIR 19; CLONING, MOLECULAR; DNA-BINDING PROTEINS; HUMAN; LEUCINE ZIPPERS; LEUKEMIA, LYMPHOCYTIC, ACUTE; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS, FUSION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION FACTORS; TRANSLOCATION (GENETICS); TUMOR CELLS, CULTURED;

EID: 0026761786     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.6.9.1608     Document Type: Article

References (8)

1. Agre, P., P.P. lohnson, and S.L. McKnight. 1989. Cognate DNA binding specificity retained after leucine zipper exchange between GCN4 and C/EBP. Science 246: 922-926.
2. Apian, P.D., O.P. Lombardi, A.M. Ginsburg, J. Cossman, V.L. Bertness, and I.R. Kirsch. 1990. Disruption of the human SCI locus by "illegitimate" V(D)J recombinase activity. Science 250: 1426-1429.
3. Brown, L., J.-T. Cheng, Q. Chen, M.J. Siciliano, W. Crist, G. Buchanan, and R. Baer. 1990. Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia. EMBO J. 9: 3343-3351.
4. Cleary, M.L. 1991. Oncogenic conversion of transcription factors by chromosomal translocations. Cell 66: 619-622.
5. Cleary, M.L., S.D. Smith, and J. Sklar. 1986. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell 47: 19-28.
6. de Thé, H., C. Lavau, A. Marchio, C. Chomienne, L. Degos, and A. Dejean. 1991. The PML-RARα fusion mRNA generated by the (15; 17) translocation in acute promyelocytic leukemia encodes functionally altered RAR. Cell 66: 675-684.
7. Drolet, D.W., K.M. Scully, D.M. Simmons, M. Wegner, K. Chu, L.W. Swanson, and M.G. Rosenfeld. 1991. THF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins. Genes &. Dev. 5: 1739-1753.
8. Gentz, R., F.J. Rauscher III, C. Abate, and T. Curran. 1989. Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains. Science 243: 1695-1699.