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Tetrahedron Letters

Volumn 33, Issue 35, 1992, Pages 5133-5136

Synthesis of potential inhibitors of the enzyme pantothenate synthetase

(4) Baillie, Alister C a Cornell, Clive L a Wright, Brian J a Wright, Kenneth a

a Schering Agrochemicals Limited Chesterford Park Research Station ^* (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; PHOSPHINIC ACID DERIVATIVE;

ARTICLE; PRIORITY JOURNAL; SYNTHESIS;

EID: 0026760245 PISSN: 00404039 EISSN: None Source Type: Journal
DOI: 10.1016/S0040-4039(00)61210-8 Document Type: Article

Times cited : (14)

References (17)

1
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3
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- Organophosphorus intermediates. VI. The acid-catalysed reaction of trialkyl orthoformates with phosphinic acid
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10
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- (1989) Tetrahedron , vol.33 , pp. 287
- Dingwall¹ Ehrenfreund² Hall³

11
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- Marschall¹ Tantau² Weyerstah³

12
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- A Convenient Synthesis of Dialkyl 1-Hydroxyalkanephosphonates using Potassium or Caesium Fluoride without Solvent
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13
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15
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- All new compounds exhibited physical and spectroscopic properties consistent with their structure. All yields quoted are unoptimised.

16
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- No compound gave evidence of competitive inhibition (at 0.3mM; [ATP] was 1OmM, [pantoate] was 5 mM and [β-alanine] was 5mM) nor was there any time-dependent inhibition observed following various conditions of preincubation (enzyme + compound, 5mM) + (i) ATP (ii) ATP + β-alanine (iii) ATP + pantoate (iv) pantoate + β-alanine); ATP, pantoate and β-alanine were at the concentrations given above. A parallel set of experiments was carried out in which AMP replaced ATP.

17
- 0000208152
- (1981) J. Am. Chem. Soc. , vol.103 , pp. 1214
- Kluger¹ Smyth²

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.