Novel Indolodioxanes with Antihypertensive Effects: Potent Ligands for the 5-HT1A Receptor

Journal of Medicinal Chemistry

Volumn 35, Issue 16, 1992, Pages 3058-3066

  Ennis, Michael D ^a   Baze, Mark E ^a   Smith, Martin W ^a   Lawson, Charles ^a   McCall, Robert B ^a   Lahti, Robert A ^a   Piercey, Montford F ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 2 [[(3 PHENYLPROPYL)AMINO]METHYL] 7H 1,4 DIOXINO[2,3 E]INDOLE 8 CARBOXYLIC ACID METHYL ESTER; ANTIHYPERTENSIVE AGENT; DIOXANE DERIVATIVE; DOPAMINE 2 RECEPTOR; INDOLE DERIVATIVE; LIGAND; SEROTONIN 1 RECEPTOR; SPIPERONE; U 86192A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BINDING AFFINITY; CAT; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG SYNTHESIS; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; SUBCUTANEOUS DRUG ADMINISTRATION; SYMPATHETIC NERVE;

ANIMAL; ANTIHYPERTENSIVE AGENTS; CATS; DIOXANES; INDOLES; LIGANDS; MALE; MICE; MOLECULAR STRUCTURE; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, ALPHA; RECEPTORS, DOPAMINE; RECEPTORS, DOPAMINE D2; RECEPTORS, OPIOID; RECEPTORS, SEROTONIN;

EID: 0026759632     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00094a021     Document Type: Article

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