Proteolytic processing of the 72,000-Da type IV collagenase by urokinase plasminogen activator

Experimental Cell Research

Volumn 202, Issue 2, 1992, Pages 471-476

  Keski Oja, Jorma ^a   Lohi, Jouko ^a   Tuuttila, Ari ^a   Tryggvason, Karl ^a   Vartio, Tapio ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF OULU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

UNIDENTIFIED BACULOVIRUS;

COLLAGENASE; GELATINASE; METALLOPROTEINASE; UROKINASE;

ARTICLE; CONNECTIVE TISSUE; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME DEGRADATION; ENZYME INDUCTION; ENZYME SUBSTRATE; FIBRINOLYSIS; FLUOROGRAPHY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; ISOTOPE LABELING; LUNG FIBROBLAST; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; REGULATORY MECHANISM;

CELL LINE; COLLAGENASES; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; GELATIN; GELATINASE A; HUMAN; IMMUNOBLOTTING; METALLOENDOPEPTIDASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; SOLUBILITY; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T; URINARY PLASMINOGEN ACTIVATOR;

EID: 0026754414     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-4827(92)90101-D     Document Type: Article

References (33)

1. Monoclonal antibodies to type IV collagenase recognize a protein with limited sequence homology to interstitial collagenase and stromelysin
2. Transforming growth factor-beta induction of type-1 plasminogen activator inhibitor. Pericellular deposition and sensitivity to exogenous urokinase.
3. Ultrastructural localization of plasma membrane-associated urokinase- type plasminogen activator at focal contacts
4. Production of gelatin-degrading matrix metalloproteinases (‘type IV collagenases’) and inhibitors by articular chondrocytes during their dedifferentiation by serial subcultures and under stimulation by interleukin-1 and tumor necrosis factor α