Prevention of spontaneous and cyclophosphamide‐induced diabetes in non‐obese diabetic (NOD) mice with oral 2‐acetyl‐4‐tetrahydroxybutyIimidazole (THI), a component of caramel colouring III

Clinical & Experimental Immunology

Volumn 88, Issue 3, 1992, Pages 414-419

  MANDEL, T E ^a   KOULMANDA, M ^a   MACKAY, I R ^b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

autoimmunity; diabetes; flow cytometry; histopathology; immunosuppression

Indexed keywords

2 ACETYL 4 TETRAHYDROXYBUTYLIMIDAZOLE; CYCLOPHOSPHAMIDE; FOOD ADDITIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNITY; DIABETES MELLITUS; FEMALE; FLOW CYTOMETRY; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SPLEEN CELL;

ADMINISTRATION, ORAL; ANIMAL; ANTIGENS, CD4; ANTIGENS, CD8; CYCLOPHOSPHAMIDE; DIABETES MELLITUS, INSULIN-DEPENDENT; FEMALE; FLOW CYTOMETRY; IMIDAZOLES; LYMPHOPENIA; MICE; MICE, INBRED NOD; SPLEEN; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0026753727     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.1992.tb06464.x     Document Type: Article

References (24)

1. Primary prevention of diabetes mellitus
2. Alkylating agents
3. The genetics of susceptibility to diabetics
4. Urocanic acid and immunosuppression
5. A short term study in the rat on two caramels produced by variations of the ‘ammonia process
6. Long‐term toxicity study in the rat on a caramel produced by the ‘half open‐half closed pan’ ammonia process
7. Lymphopenic effects on mice of a component of ammonia caramel. 2‐acetyl‐4(5)‐tetrahydroxybutylimidazole (THI)
8. The effect of 2‐acetyl‐4‐tetra‐hydroxybutylimidazole on lymphocyte subsets in peripheral blood of the rat
9. In vivo administration of a component of caramel coloring affects immune competence in the rat
10. Immunosuppressive effects of 2‐acetyl‐4‐teirahydroxybutyl imidazole (THI) in the rat
11. Breeding of a non‐obese diabetic strain of mice
12. Promotion of spontaneous diabetes in nonobese diabetes‐prone mice by cyclophosphamide
13. Anti‐suppressor effect of cyclophosphamide on the development of spontaneous diabetes in NOD mice
14. Cyclophosphamide‐induced diabetes in NOD/Wehi mice. Evidence for suppression in spontaneous autoimmune diabetes mellitus
15. Comparison of high‐ and low diabetes‐incidence NOD mouse strains
16. High‐ and low‐diabetes‐incidence nonobese diabetic (NOD) mice: origins and characterization
17. The effect of pyridoxine on the number of lymphocytes in blood of rats led ammonia caramel colour
18. Physiological characteristics
19. The influence of histamine on immune and inflammatory responses
20. Histamine modulation of lymphocyte biology: membrane receptors, signal transduction. and functions
21. Effect of mizoribine on lupus nephropathy of New Zealand black/white FI hybrid mice
22. Immunosuppressive effect of bredinin on cell‐mediated and humoral immune reactions in experimental animals
23. Experimental models of human autoimmune disease: overview and prototypes