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Volumn 52, Issue 14, 1992, Pages 3892-3900

Identification of Novel Antimitotic Agents Acting at the Tubulin Level by Computer-assisted Evaluation of Differential Cytotoxicity Data

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE DERIVATIVE; DOLASTATIN; HALICHONDRIN B; MAYTANSINE; PACLITAXEL; PODOPHYLLOTOXIN DERIVATIVE; TENIPOSIDE; VINBLASTINE DERIVATIVE; VINCRISTINE;

EID: 0026752669     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (203)

References (26)
  • 1
    • 77955635811 scopus 로고
    • National Cancer Institute drug discovery and development.
    • In: E. J. Frei and E. J. Freireich (eds.) Philadelphia: J. B. Lippincott Co.
    • Boyd, M. R. National Cancer Institute drug discovery and development. In: E. J. Frei and E. J. Freireich (eds.), Accomplishments in Oncology, pp. 68-76. Philadelphia: J. B. Lippincott Co., 1986.
    • (1986) Accomplishments in Oncology , pp. 68-76
    • Boyd, M.R.1
  • 2
    • 0000719887 scopus 로고
    • Status of the NCI preclincial antitumor drug discovery screen.
    • In: V. T. DeVita, S. Hellman, and S. A. Rosenberg (eds.) Philadelphia: J. B. Lippincott Co.
    • Boyd, M. R. Status of the NCI preclincial antitumor drug discovery screen. In: V. T. DeVita, S. Hellman, and S. A. Rosenberg (eds.). Cancer: Principles and Practice of Oncology Updates, pp. 1-12. Philadelphia: J. B. Lippincott Co., 1989.
    • (1989) Cancer: Principles and Practice of Oncology Updates , pp. 1-12
    • Boyd, M.R.1
  • 4
    • 0024312538 scopus 로고
    • Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm
    • Paull, K. D., Shoemaker, R. H., Hodes, L., Monks, A., Scudiero, D. A., Rubinstein, L., Plowman, J., and Boyd, M. R. Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm. J. Natl. Cancer Inst., 81: 1088-1092, 1989.
    • (1989) J. Natl. Cancer Inst. , vol.81 , pp. 1088-1092
    • Paull, K.D.1    Shoemaker, R.H.2    Hodes, L.3    Monks, A.4    Scudiero, D.A.5    Rubinstein, L.6    Plowman, J.7    Boyd, M.R.8
  • 5
    • 0021163546 scopus 로고
    • Separation of active tubulin and microtubule-associated proteins by ultracentrifugation and isolation of a component causing the formation of microtubule bundles
    • Hamel, E., and Lin, C. M. Separation of active tubulin and microtubule-associated proteins by ultracentrifugation and isolation of a component causing the formation of microtubule bundles. Biochemistry, 23: 4173-4184, 1984.
    • (1984) Biochemistry , vol.23 , pp. 4173-4184
    • Hamel, E.1    Lin, C.M.2
  • 6
    • 0022407184 scopus 로고
    • Differential effects of magnesium on tubulin-nucleotide interactions
    • Huang, A. B., Lin, C. M., and Hamel, E. Differential effects of magnesium on tubulin-nucleotide interactions. Biochim. Biophys. Acta, 832: 22-32, 1985.
    • (1985) Biochim. Biophys. Acta , vol.832 , pp. 22-32
    • Huang, A.B.1    Lin, C.M.2    Hamel, E.3
  • 7
    • 0025302762 scopus 로고
    • Synthesis and Biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization
    • Jiang, J. B., Hesson, D. P., Dusak, B. A., Dexter, D. L., Kang, G. J., and Hamel, E. Synthesis and Biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization. J. Med. Chem., 33: 1721-1728, 1990.
    • (1990) J. Med. Chem. , vol.33 , pp. 1721-1728
    • Jiang, J.B.1    Hesson, D.P.2    Dusak, B.A.3    Dexter, D.L.4    Kang, G.J.5    Hamel, E.6
  • 8
    • 0026582270 scopus 로고
    • Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions
    • Getahun, Z., Jurd, L., Chu, P. S., Lin, C. M., and Hamel, E. Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions. J. Med. Chem., 35: 1058-1067, 1992.
    • (1992) J. Med. Chem. , vol.35 , pp. 1058-1067
    • Getahun, Z.1    Jurd, L.2    Chu, P.S.3    Lin, C.M.4    Hamel, E.5
  • 9
    • 0015442186 scopus 로고
    • A rapid method for quantitative determination of microtubule protein using DEAE-cellulose filters
    • Borisy, G. G. A rapid method for quantitative determination of microtubule protein using DEAE-cellulose filters. Anal. Biochem., 50: 373-385, 1972.
    • (1972) Anal. Biochem. , vol.50 , pp. 373-385
    • Borisy, G.G.1
  • 10
    • 0021198812 scopus 로고
    • Guanosine 5′-O-(3-thiotriphosphate), a potent nucleotide inhibitor of microtubule assembly
    • Hamel, E., and Lin, C. M. Guanosine 5′-O-(3-thiotriphosphate), a potent nucleotide inhibitor of microtubule assembly. J. Biol. Chem., 259: 11060-11069, 1984.
    • (1984) J. Biol. Chem. , vol.259 , pp. 11060-11069
    • Hamel, E.1    Lin, C.M.2
  • 11
    • 0026069885 scopus 로고
    • Halichondrin B and homohalichondrin B., marine natural products binding in the vinca domain of tubulin: discover of tubulin-based mechanism of action by analysis of differential cytotoxicity data.
    • Bai, R., Paull, K. D., Herald, C. L., Malspeis, L., Pettit, G. R., and Hamel, E. Halichondrin B and homohalichondrin B., marine natural products binding in the vinca domain of tubulin: discover of tubulin-based mechanism of action by analysis of differential cytotoxicity data. J. Biol. Chem., 266: 15882-15889, 1991.
    • (1991) J. Biol. Chem. , vol.266 , pp. 15882-15889
    • Bai, R.1    Paull, K.D.2    Herald, C.L.3    Malspeis, L.4    Pettit, G.R.5    Hamel, E.6
  • 12
    • 0022709534 scopus 로고
    • Halichondrins-antitumor polyether macrolides from a marine sponge
    • Hirata, V., and Uemura, D. Halichondrins-antitumor polyether macrolides from a marine sponge. Pure Appl. Chem., 58: 701-710, 1986.
    • (1986) Pure Appl. Chem. , vol.58 , pp. 701-710
    • Hirata, V.1    Uemura, D.2
  • 14
    • 0021912989 scopus 로고
    • Structure-function studies with derivatives of 6-benzyl-1,3-benzodioxole, a new class of synthetic compounds which inhibit tubulin polymerization and mitosis
    • Batra, J. K., Jurd, L., and Hamel, E. Structure-function studies with derivatives of 6-benzyl-1,3-benzodioxole, a new class of synthetic compounds which inhibit tubulin polymerization and mitosis. Mol. Pharmacol., 27:94-102, 1985.
    • (1985) Mol. Pharmacol. , vol.27 , pp. 94-102
    • Batra, J.K.1    Jurd, L.2    Hamel, E.3
  • 15
    • 0023893833 scopus 로고
    • Cornigerine, a potent antimitotic Colchicum alkaloid of unusual structure
    • Hamel, E., Ho, H. H., Kang, G-J., and Lin, C. M. Cornigerine, a potent antimitotic Colchicum alkaloid of unusual structure. Biochem. Pharmacol., 37: 2445-2449, 1988.
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 2445-2449
    • Hamel, E.1    Ho, H.H.2    Kang, G.-J.3    Lin, C.M.4
  • 16
    • 0024427745 scopus 로고
    • Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin
    • Lin, C. M., Ho, H. H., Pettit, G. R., and Hamel, E. Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin. Biochemistry, 28: 6984-6991, 1989.
    • (1989) Biochemistry , vol.28 , pp. 6984-6991
    • Lin, C.M.1    Ho, H.H.2    Pettit, G.R.3    Hamel, E.4
  • 17
    • 0020477454 scopus 로고
    • Polymerization of the tubulin-colchicine complex and guanosine 5′-triphosphate hydrolysis
    • Saltarelli, D., and Pantaloni, D. Polymerization of the tubulin-colchicine complex and guanosine 5′-triphosphate hydrolysis. Biochemistry, 21:2996-3006, 1982.
    • (1982) Biochemistry , vol.21 , pp. 2996-3006
    • Saltarelli, D.1    Pantaloni, D.2
  • 18
    • 0242414439 scopus 로고
    • Tubulin bound to colchicine forms polymers different from microtubules
    • Andreu, J. M., and Timasheff, S. N. Tubulin bound to colchicine forms polymers different from microtubules. Proc. Natl. Acad. Sci. USA, 79:6753-6756, 1982.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 6753-6756
    • Andreu, J.M.1    Timasheff, S.N.2
  • 19
    • 0025099365 scopus 로고
    • Antitubulin effects of derivatives of 3-demethylthiocoichicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine
    • Muzaffar, A., Brossi, A., Lin, C. M., and Hamel, E. Antitubulin effects of derivatives of 3-demethylthiocoichicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids. J. Med. Chem., 33: 567-571, 1990.
    • (1990) Comparison with colchicinoids. J. Med. Chem. , vol.33 , pp. 567-571
    • Muzaffar, A.1    Brossi, A.2    Lin, C.M.3    Hamel, E.4
  • 20
    • 0025352537 scopus 로고
    • Dolastatin 10, a powerful cytostatic peptide derived from a marine animal: inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain
    • Bai, R., Pettit, G. R., and Hamel, E. Dolastatin 10, a powerful cytostatic peptide derived from a marine animal: inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain. Biochem. Pharmacol., 39: 1941-1949, 1990.
    • (1990) Biochem. Pharmacol. , vol.39 , pp. 1941-1949
    • Bai, R.1    Pettit, G.R.2    Hamel, E.3
  • 21
    • 0024600993 scopus 로고
    • Tubulin-dependent hydrolysis of GTP as a screening test to identify new antimitotic agents: application to carbamates of aromatic amines
    • Duanmu, C., Shahrik, L., Ho, H. H., and Hamel, E. Tubulin-dependent hydrolysis of GTP as a screening test to identify new antimitotic agents: application to carbamates of aromatic amines. Cancer Res., 49: 1344-1348, 1989.
    • (1989) Cancer Res. , vol.49 , pp. 1344-1348
    • Duanmu, C.1    Shahrik, L.2    Ho, H.H.3    Hamel, E.4
  • 22
    • 0018570883 scopus 로고
    • Effect of antimitotic drugs on tubulin GTPase activity and self-assembly
    • David-Pfeuty, T., Simon, C., and Pantaloni, D. Effect of antimitotic drugs on tubulin GTPase activity and self-assembly. J. Biol. Chem., 254: 11696-11702, 1979.
    • (1979) J. Biol. Chem. , vol.254 , pp. 11696-11702
    • David-Pfeuty, T.1    Simon, C.2    Pantaloni, D.3
  • 23
    • 0019833086 scopus 로고
    • Effects of inhibitors of tubulin polymerization on GTP hydrolysis
    • Lin, C. M., and Hamel, E. Effects of inhibitors of tubulin polymerization on GTP hydrolysis. J. Biol. Chem., 256:9242-9245, 1981.
    • (1981) J. Biol. Chem. , vol.256 , pp. 9242-9245
    • Lin, C.M.1    Hamel, E.2
  • 24
    • 0025836773 scopus 로고
    • Investigation of the mechanism of the interaction of tubulin with derivatives of 2-styrylquinazolin-4(3H)one
    • Lin, C. M., Kang, G. J., Roach, M. C., Jiang, J. B., Hesson, D. P., Luduena, R. F., and Hamel, E. Investigation of the mechanism of the interaction of tubulin with derivatives of 2-styrylquinazolin-4(3H)one. Mol. Pharmacol., 40: 827-832, 1991.
    • (1991) Mol. Pharmacol. , vol.40 , pp. 827-832
    • Lin, C.M.1    Kang, G.J.2    Roach, M.C.3    Jiang, J.B.4    Hesson, D.P.5    Luduena, R.F.6    Hamel, E.7
  • 25
    • 0026748367 scopus 로고
    • Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricuLaria: interaction with tubulin and effects on cellular microtubules
    • Bai, R., Friedman, S. J., Pettit, G. R., and Hamel, E. Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricuLaria: interaction with tubulin and effects on cellular microtubules. Biochem. Pharmacol., in press, 1992.
    • (1992) Biochem. Pharmacol.
    • Bai, R.1    Friedman, S.J.2    Pettit, G.R.3    Hamel, E.4
  • 26
    • 85063514735 scopus 로고
    • Interactions of tubulin with small ligands.
    • In: J. Avila (ed.) Boca Raton, FL: CRC Press
    • Hamel, E. Interactions of tubulin with small ligands. In: J. Avila (ed.), Microtubule Proteins, pp. 89-191. Boca Raton, FL: CRC Press, 1990.
    • (1990) Microtubule Proteins , pp. 89-191
    • Hamel, E.1


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