-
1
-
-
77955635811
-
National Cancer Institute drug discovery and development.
-
In: E. J. Frei and E. J. Freireich (eds.) Philadelphia: J. B. Lippincott Co.
-
Boyd, M. R. National Cancer Institute drug discovery and development. In: E. J. Frei and E. J. Freireich (eds.), Accomplishments in Oncology, pp. 68-76. Philadelphia: J. B. Lippincott Co., 1986.
-
(1986)
Accomplishments in Oncology
, pp. 68-76
-
-
Boyd, M.R.1
-
2
-
-
0000719887
-
Status of the NCI preclincial antitumor drug discovery screen.
-
In: V. T. DeVita, S. Hellman, and S. A. Rosenberg (eds.) Philadelphia: J. B. Lippincott Co.
-
Boyd, M. R. Status of the NCI preclincial antitumor drug discovery screen. In: V. T. DeVita, S. Hellman, and S. A. Rosenberg (eds.). Cancer: Principles and Practice of Oncology Updates, pp. 1-12. Philadelphia: J. B. Lippincott Co., 1989.
-
(1989)
Cancer: Principles and Practice of Oncology Updates
, pp. 1-12
-
-
Boyd, M.R.1
-
3
-
-
0025775062
-
Feasibility of a high-flux anticancer drug screen utilizing a diverse panel of human tumor cell lines in culture
-
Monks, A., Scudiero, D., Skehan, P., Shoemaker, R., Paull, K., Vistica, D., Hose, C., Langley, J., Cronise, P., Vaigro-Wolff, A., Gray-Goodrich, M., Campbell, H., Mayo, J., and Boyd, M. Feasibility of a high-flux anticancer drug screen utilizing a diverse panel of human tumor cell lines in culture. J. Natl. Cancer Inst., 8S: 757-766, 1991.
-
(1991)
J. Natl. Cancer Inst.
, pp. 757-766
-
-
Monks, A.1
Scudiero, D.2
Skehan, P.3
Shoemaker, R.4
Paull, K.5
Vistica, D.6
Hose, C.7
Langley, J.8
Cronise, P.9
Vaigro-Wolff, A.10
Gray-Goodrich, M.11
Campbell, H.12
Mayo, J.13
Boyd, M.14
-
4
-
-
0024312538
-
Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm
-
Paull, K. D., Shoemaker, R. H., Hodes, L., Monks, A., Scudiero, D. A., Rubinstein, L., Plowman, J., and Boyd, M. R. Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm. J. Natl. Cancer Inst., 81: 1088-1092, 1989.
-
(1989)
J. Natl. Cancer Inst.
, vol.81
, pp. 1088-1092
-
-
Paull, K.D.1
Shoemaker, R.H.2
Hodes, L.3
Monks, A.4
Scudiero, D.A.5
Rubinstein, L.6
Plowman, J.7
Boyd, M.R.8
-
5
-
-
0021163546
-
Separation of active tubulin and microtubule-associated proteins by ultracentrifugation and isolation of a component causing the formation of microtubule bundles
-
Hamel, E., and Lin, C. M. Separation of active tubulin and microtubule-associated proteins by ultracentrifugation and isolation of a component causing the formation of microtubule bundles. Biochemistry, 23: 4173-4184, 1984.
-
(1984)
Biochemistry
, vol.23
, pp. 4173-4184
-
-
Hamel, E.1
Lin, C.M.2
-
6
-
-
0022407184
-
Differential effects of magnesium on tubulin-nucleotide interactions
-
Huang, A. B., Lin, C. M., and Hamel, E. Differential effects of magnesium on tubulin-nucleotide interactions. Biochim. Biophys. Acta, 832: 22-32, 1985.
-
(1985)
Biochim. Biophys. Acta
, vol.832
, pp. 22-32
-
-
Huang, A.B.1
Lin, C.M.2
Hamel, E.3
-
7
-
-
0025302762
-
Synthesis and Biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization
-
Jiang, J. B., Hesson, D. P., Dusak, B. A., Dexter, D. L., Kang, G. J., and Hamel, E. Synthesis and Biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization. J. Med. Chem., 33: 1721-1728, 1990.
-
(1990)
J. Med. Chem.
, vol.33
, pp. 1721-1728
-
-
Jiang, J.B.1
Hesson, D.P.2
Dusak, B.A.3
Dexter, D.L.4
Kang, G.J.5
Hamel, E.6
-
8
-
-
0026582270
-
Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions
-
Getahun, Z., Jurd, L., Chu, P. S., Lin, C. M., and Hamel, E. Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions. J. Med. Chem., 35: 1058-1067, 1992.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 1058-1067
-
-
Getahun, Z.1
Jurd, L.2
Chu, P.S.3
Lin, C.M.4
Hamel, E.5
-
9
-
-
0015442186
-
A rapid method for quantitative determination of microtubule protein using DEAE-cellulose filters
-
Borisy, G. G. A rapid method for quantitative determination of microtubule protein using DEAE-cellulose filters. Anal. Biochem., 50: 373-385, 1972.
-
(1972)
Anal. Biochem.
, vol.50
, pp. 373-385
-
-
Borisy, G.G.1
-
10
-
-
0021198812
-
Guanosine 5′-O-(3-thiotriphosphate), a potent nucleotide inhibitor of microtubule assembly
-
Hamel, E., and Lin, C. M. Guanosine 5′-O-(3-thiotriphosphate), a potent nucleotide inhibitor of microtubule assembly. J. Biol. Chem., 259: 11060-11069, 1984.
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 11060-11069
-
-
Hamel, E.1
Lin, C.M.2
-
11
-
-
0026069885
-
Halichondrin B and homohalichondrin B., marine natural products binding in the vinca domain of tubulin: discover of tubulin-based mechanism of action by analysis of differential cytotoxicity data.
-
Bai, R., Paull, K. D., Herald, C. L., Malspeis, L., Pettit, G. R., and Hamel, E. Halichondrin B and homohalichondrin B., marine natural products binding in the vinca domain of tubulin: discover of tubulin-based mechanism of action by analysis of differential cytotoxicity data. J. Biol. Chem., 266: 15882-15889, 1991.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 15882-15889
-
-
Bai, R.1
Paull, K.D.2
Herald, C.L.3
Malspeis, L.4
Pettit, G.R.5
Hamel, E.6
-
12
-
-
0022709534
-
Halichondrins-antitumor polyether macrolides from a marine sponge
-
Hirata, V., and Uemura, D. Halichondrins-antitumor polyether macrolides from a marine sponge. Pure Appl. Chem., 58: 701-710, 1986.
-
(1986)
Pure Appl. Chem.
, vol.58
, pp. 701-710
-
-
Hirata, V.1
Uemura, D.2
-
13
-
-
0026356420
-
C Isolation and structure of the cell growth inhibitory constituents from the Western Pacific marine sponge Axinella sp
-
Pettit, G. R., Herald, C. L., Boyd, M. R., Leet, J. E., Dufresne, C., Doubek, D. L., Schmidt, J. M., Cerny, R. L., Hooper, J. N. A., and Rutzler, K. C Isolation and structure of the cell growth inhibitory constituents from the Western Pacific marine sponge Axinella sp. J. Med. Chem., 34: 3339-3340, 1991.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 3339-3340
-
-
Pettit, G.R.1
Herald, C.L.2
Boyd, M.R.3
Leet, J.E.4
Dufresne, C.5
Doubek, D.L.6
Schmidt, J.M.7
Cerny, R.L.8
Hooper, J.N.A.9
Rutzler, K.10
-
14
-
-
0021912989
-
Structure-function studies with derivatives of 6-benzyl-1,3-benzodioxole, a new class of synthetic compounds which inhibit tubulin polymerization and mitosis
-
Batra, J. K., Jurd, L., and Hamel, E. Structure-function studies with derivatives of 6-benzyl-1,3-benzodioxole, a new class of synthetic compounds which inhibit tubulin polymerization and mitosis. Mol. Pharmacol., 27:94-102, 1985.
-
(1985)
Mol. Pharmacol.
, vol.27
, pp. 94-102
-
-
Batra, J.K.1
Jurd, L.2
Hamel, E.3
-
15
-
-
0023893833
-
Cornigerine, a potent antimitotic Colchicum alkaloid of unusual structure
-
Hamel, E., Ho, H. H., Kang, G-J., and Lin, C. M. Cornigerine, a potent antimitotic Colchicum alkaloid of unusual structure. Biochem. Pharmacol., 37: 2445-2449, 1988.
-
(1988)
Biochem. Pharmacol.
, vol.37
, pp. 2445-2449
-
-
Hamel, E.1
Ho, H.H.2
Kang, G.-J.3
Lin, C.M.4
-
16
-
-
0024427745
-
Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin
-
Lin, C. M., Ho, H. H., Pettit, G. R., and Hamel, E. Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin. Biochemistry, 28: 6984-6991, 1989.
-
(1989)
Biochemistry
, vol.28
, pp. 6984-6991
-
-
Lin, C.M.1
Ho, H.H.2
Pettit, G.R.3
Hamel, E.4
-
17
-
-
0020477454
-
Polymerization of the tubulin-colchicine complex and guanosine 5′-triphosphate hydrolysis
-
Saltarelli, D., and Pantaloni, D. Polymerization of the tubulin-colchicine complex and guanosine 5′-triphosphate hydrolysis. Biochemistry, 21:2996-3006, 1982.
-
(1982)
Biochemistry
, vol.21
, pp. 2996-3006
-
-
Saltarelli, D.1
Pantaloni, D.2
-
18
-
-
0242414439
-
Tubulin bound to colchicine forms polymers different from microtubules
-
Andreu, J. M., and Timasheff, S. N. Tubulin bound to colchicine forms polymers different from microtubules. Proc. Natl. Acad. Sci. USA, 79:6753-6756, 1982.
-
(1982)
Proc. Natl. Acad. Sci. USA
, vol.79
, pp. 6753-6756
-
-
Andreu, J.M.1
Timasheff, S.N.2
-
19
-
-
0025099365
-
Antitubulin effects of derivatives of 3-demethylthiocoichicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine
-
Muzaffar, A., Brossi, A., Lin, C. M., and Hamel, E. Antitubulin effects of derivatives of 3-demethylthiocoichicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids. J. Med. Chem., 33: 567-571, 1990.
-
(1990)
Comparison with colchicinoids. J. Med. Chem.
, vol.33
, pp. 567-571
-
-
Muzaffar, A.1
Brossi, A.2
Lin, C.M.3
Hamel, E.4
-
20
-
-
0025352537
-
Dolastatin 10, a powerful cytostatic peptide derived from a marine animal: inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain
-
Bai, R., Pettit, G. R., and Hamel, E. Dolastatin 10, a powerful cytostatic peptide derived from a marine animal: inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain. Biochem. Pharmacol., 39: 1941-1949, 1990.
-
(1990)
Biochem. Pharmacol.
, vol.39
, pp. 1941-1949
-
-
Bai, R.1
Pettit, G.R.2
Hamel, E.3
-
21
-
-
0024600993
-
Tubulin-dependent hydrolysis of GTP as a screening test to identify new antimitotic agents: application to carbamates of aromatic amines
-
Duanmu, C., Shahrik, L., Ho, H. H., and Hamel, E. Tubulin-dependent hydrolysis of GTP as a screening test to identify new antimitotic agents: application to carbamates of aromatic amines. Cancer Res., 49: 1344-1348, 1989.
-
(1989)
Cancer Res.
, vol.49
, pp. 1344-1348
-
-
Duanmu, C.1
Shahrik, L.2
Ho, H.H.3
Hamel, E.4
-
22
-
-
0018570883
-
Effect of antimitotic drugs on tubulin GTPase activity and self-assembly
-
David-Pfeuty, T., Simon, C., and Pantaloni, D. Effect of antimitotic drugs on tubulin GTPase activity and self-assembly. J. Biol. Chem., 254: 11696-11702, 1979.
-
(1979)
J. Biol. Chem.
, vol.254
, pp. 11696-11702
-
-
David-Pfeuty, T.1
Simon, C.2
Pantaloni, D.3
-
23
-
-
0019833086
-
Effects of inhibitors of tubulin polymerization on GTP hydrolysis
-
Lin, C. M., and Hamel, E. Effects of inhibitors of tubulin polymerization on GTP hydrolysis. J. Biol. Chem., 256:9242-9245, 1981.
-
(1981)
J. Biol. Chem.
, vol.256
, pp. 9242-9245
-
-
Lin, C.M.1
Hamel, E.2
-
24
-
-
0025836773
-
Investigation of the mechanism of the interaction of tubulin with derivatives of 2-styrylquinazolin-4(3H)one
-
Lin, C. M., Kang, G. J., Roach, M. C., Jiang, J. B., Hesson, D. P., Luduena, R. F., and Hamel, E. Investigation of the mechanism of the interaction of tubulin with derivatives of 2-styrylquinazolin-4(3H)one. Mol. Pharmacol., 40: 827-832, 1991.
-
(1991)
Mol. Pharmacol.
, vol.40
, pp. 827-832
-
-
Lin, C.M.1
Kang, G.J.2
Roach, M.C.3
Jiang, J.B.4
Hesson, D.P.5
Luduena, R.F.6
Hamel, E.7
-
25
-
-
0026748367
-
Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricuLaria: interaction with tubulin and effects on cellular microtubules
-
Bai, R., Friedman, S. J., Pettit, G. R., and Hamel, E. Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricuLaria: interaction with tubulin and effects on cellular microtubules. Biochem. Pharmacol., in press, 1992.
-
(1992)
Biochem. Pharmacol.
-
-
Bai, R.1
Friedman, S.J.2
Pettit, G.R.3
Hamel, E.4
-
26
-
-
85063514735
-
Interactions of tubulin with small ligands.
-
In: J. Avila (ed.) Boca Raton, FL: CRC Press
-
Hamel, E. Interactions of tubulin with small ligands. In: J. Avila (ed.), Microtubule Proteins, pp. 89-191. Boca Raton, FL: CRC Press, 1990.
-
(1990)
Microtubule Proteins
, pp. 89-191
-
-
Hamel, E.1
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