The suppression of hepatic cytochrome P4504A mRNA mediated by the interferon inducer polyinosinic acid- poly cytidylic acid

Biochemical Pharmacology

Volumn 44, Issue 3, 1992, Pages 604-608

  Knickle, Leah C ^a   Spencer, David F ^a   Renton, Kenneth W ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CLOFIBRATE; CYTOCHROME P450 ISOENZYME; INTERFERON INDUCING AGENT; LAURIC ACID; MESSENGER RNA; POLYINOSINIC POLYCYTIDYLIC ACID;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER MICROSOME; MALE; NONHUMAN; NORTHERN BLOTTING; NUCLEIC ACID HYBRIDIZATION; PRIORITY JOURNAL; RAT;

ANIMAL; BASE SEQUENCE; CLOFIBRATE; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; GENE EXPRESSION REGULATION; INTERFERONS; LAURIC ACIDS; MALE; MICROSOMES, LIVER; MOLECULAR SEQUENCE DATA; POLY I-C; RATS; RATS, INBRED STRAINS; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T;

EID: 0026750741     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(92)90458-U     Document Type: Article

References (28)

1. Depression of the hepatic cytochrome P-450 mono-oxygenase system by administered tilorone {2,7-bis[2-(diethylamino)ethoxy] fluoren-9-one dihydrochloride}
2. Decrease in the activity of the drug metabolizing enzymes of rat liver following the administration of tilorone hydrochloride
3. Depression of hepatic cytochrome P-450-dependent monooxygenase systems with administered interferon inducing agents
4. Homogeneous interferon from E. coli depresses hepatic cytochrome P-450 and drug biotransformation
5. Effects of three recombinant human leukocyte interferons on drug metbolism in mice
6. Effect of interferon on murine cytochrome P-450 Effect of partially purified antigen specific interferon-gamma
7. Effect of murine gamma interferon on the mouse liver and its drug-metabolizing enzymes: Comparison with human hybrid alpha-interferon
8. Relationship between the antiviral effects of interferons and their abilities to depress cytochrome P-450
9. Rat but not human interferons suppress hepatic oxidative drug metabolism in rats
10. Effect of interferon inducing agents (polyriboinosinic acid-polyribocytidylic acid and tilorone) on the heme turnover of hepatic cytochrome P-450
11. Inhibition of the synthesis of hepatic cytochrome P-450 by the interferon-inducing agent poly rI·rC
12. 1] on hepatic cytochrome P-450 and protein synthesis and degradation in hepatic microsomes
13. Interferon down regulates the male-specific cytochrome P450IIIA2 in rat liver
14. Pretranslational suppression of cytochrome P-450h (IIC11) gene expression in rat liver after administration of interferon inducers
15. Regulation of hepatic cytochrome P-450 during infectious disease
16. Isolation, complementary DNA sequence, and regulation of rat hepatic lauric acid (ω-hydroxylase (cytochrome P-450LA ω): Identification of a new cytochrome P-450 gene family
17. Sex-dependent differences in drug metabolism in the rat. II. Qualitative changes produced by castration and the administration of steroid hormones and phenobarbital.
18. Protein measurement with the Folin phenol reagent
19. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
20. The effect of hypolipidemic agents on the hepatic microsomal drug-metabolizing enzyme system of the rat: Induction of cytochrome(s) P-450 with specificity toward terminal hydroxylation of lauric acid
21. Isolation and characterization of a cDNA clone specific for avian vitellogenin II
22. Sequencing end-labeled DNA with base-specific chemical cleavages
23. Hybridization of oligo(dT) to RNA on nitrocellulose
24. Suppression of P450IIC12 gene expression and elevation of actin messenger ribonucleic acid levels in the livers of female rats after injection of the interferon inducer poly rI·poly rC
25. Differential effects of recombinant interferon α on constitutive and inducible cytochrome P450 isozymes in mouse liver
26. Potentiation and suppression of mouse liver cytochrome P-450 isozymes during the acute-phase response induced by bacterial endotoxin
27. Regulation of cytochrome P450IIC12 expression by interleukin 1α, interleukin-6 and dexamethasone
28. Effect of interleukin 6 on phenobarbital induction of cytochrome P450IIB in cultured rat hepatocytes