Mechanisms of mouse spleen dendritic cell function in the generation of influenza-specific, cytolytic T lymphocytes

Journal of Experimental Medicine

Volumn 176, Issue 2, 1992, Pages 519-529

  Nonacs, Ruta ^a   Humborg, Cornelia ^a   Tam, James P ^b   Steinman, Ralph M ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b Laboratory of Biochemistry   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROMELAIN; CD4 ANTIGEN; HELPER FACTOR; LYMPHOKINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NUCLEOPROTEIN; VIRUS ANTIGEN; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; CELL FUNCTION; CELL LINE; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; FEMALE; HELPER CELL; INFLUENZA VIRUS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SPLEEN CELL; T LYMPHOCYTE; ULTRAVIOLET IRRADIATION; VIRUS REPLICATION;

AMINO ACID SEQUENCE; ANIMAL; ANTIGENS, CD4; CELL LINE; DENDRITIC CELLS; FEMALE; INFLUENZA A VIRUS, HUMAN; MALE; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; NUCLEOPROTEINS; SPLEEN; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, HELPER-INDUCER; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 0026750280     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.176.2.519     Document Type: Article

References (65)

1. Kees, U., and P.H. Krammer. 1984. Most influenza A virus-specific memory cytotoxic T lymphocytes react with antigenic epitopes associated with internal virus determinants. J. Exp. Med. 159:365.
2. Braciale, T.J. 1977 Immunologic recognition of influenza virus-infected. 1. Generation of a virus-strain specific and a crossreactive subpopulation of cytotoxic T cells in the response to type A influenza viruses of different subtypes. Cell. Immunol. 33:423.
3. Zweerink, H.J., B.A. Askonas, D. Millican, S.A. Courthedge, and J.J. Skehel. 1977. Cytotoxic T cells to type A hemagglutinin: Viral hemagglutinin induces A-strain-specificity while infected cells confer cross-reactive cytotoxicity. Eur. J. Immunol. 7:630.
4. McMichael, A.J., and B.A. Askonas. 1978. Influenza virus-specific cytotoxic T cells in man: induction and properties of the cytotoxic cell. Eur. J. Immunol. 8:705.
5. Lukacher, A.E., V.L. Braciale, and T.J. Braciale. 1984. In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific. J. Exp Med. 160:814.
6. Lin, Y.L., and B. Askonas. 1981. Biological properties of an influenza A virus-specific killer T cell clone: inhibition of virus replication in vivo and induction of delayed-type hypersensitivity reactions. J. Exp Med. 154:225.
7. Yap, K.L., G.L. Ada, and I.F.G. McKenzie. 1978. Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virus. Nature (Land.). 273:238.
8. McMichael, A.J., F.M. Gotch, G.R. Noble, and P.A.S. Beare. 1983. Cytotoxic T-cell immunity to influenza. N. Engl.J. Med. 309:13.
9. Zinkernagel, R.M., and P.C. Doherty. 1974. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature (Lond.). 248:701.
10. Doherty, P.C., and R.M. Zingernagel. 1975. FI-2 compatibility is required for T cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. J. Exp Med. 141:502.
11. Townsend, A.R.M., F.M. Gotch, andj. Davey. 1985. Cytotoxic T cells recognize fragments of the influenza nucleoprotein. Cell. 42:457.
12. Morrison, L.A., A.E. Lukacher, V.L. Braciale, D.P. Fan, and T.J. Braciale. 1986. Differences in antigen presentation to MHC class I- and class II-restricted influenza virus-specific cytolytic T lymphocyte clones. J. Exp Med. 163:903.
13. Macatonia, S.E., P.M. Taylor, S.D. Knight, and B. A. Askonas. 1989. Primary stimulation by dendritic cells induces anti-viral proliferative and cytotoxic T cell responses in vitro. J. Exp Med. 169:1255.
14. Hengel, H., M. Lindner, H. Wagner, and K. Heeg. 1987. Frequency of herpes simplex virus-specific murine cytotoxic T lymphocyte precursors in mitogen- and antigen-driven primary in vitro T cell responses. J. Immunol. 139:4196.
15. Kast, W.M., C.J.P. Wong, B.O. Roep, A.C. Voordouw, and CJ.M. Melief. 1988. Failure or success in the restoration of virus-specific cytotoxic T lymphocyte response defects by dendritic cells. J. Immunol. 140:3186.
16. Macatonia, S.E., S. Patterson, and S.C. Knight. 1991. Primary proliferative and cytotoxic T cell response to HIV induced in vitro by human dendritic cells. Immunology. 74:399.
17. Rock, K.L., S. Gamble, andL. Rothstein. 1990. Presentation of exogenous antigen with class I major histocompatibility complex molecules. Science (Wash. DC). 249:918.
18. Carbone, F.R., and M.J. Bevan. 1990. Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo.J. Exp Med. 171:377.
19. Bevan, M.J. 1976. Cross-priming for a secondary cytotoxic response to minor H. antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.J. Exp Med. 143:1283.
20. Korngold, R., and J. Sprent. 1980. Selection of cytotoxic T-cell precursors specific for minor histocompatibility determinants. 1. Negative selection across H-2 barriers induced with disrupted cells but not with glutaraldehyde-treated cells: evidence for antigen processing. J. Exp Med. 151:314.
21. + cytotoxic T lymphocytes by dendritic cells. J. Exp Med. 166:182.
22. + helper T cells. J. Exp Med. 171:1315.
23. + helper cell requirement in cytotoxic T lymphocyte responses. Eur. J. Immunol. 18:219.
24. Brand, C.M., and J.J. Skehel. 1972. Crystalline antigen from the influenza virus envelope. Nature (Lond.). 238:145.
25. Crowley, M., K. Inaba, M. Witmer-Pack, and R.M. Steinman. 1989. The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus. Celt. Immunol. 118:108.
26. Wibo, M., and B. Poole. 1974. Protein degradation in cultured cells. II. The uptake of chloroquine by rat fibroblasts and the inhibition of cellular protein degradation and cathepsin B. J. Cell Biol. 63:430.
27. Rotzschke, O., K. Falk, K. Deres, H. Schild, M. Norda, J. Metzger, G. Jung, and H.-G. Rammensee. 1990. Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells. Nature (Lond.). 348:252.
28. Merrifield, B. 1986. Solid phase synthesis. Science (Wash. DC). 232:341.
29. Yewdell, J.W., A. Yellen, and T. Bachi. 1988. Monoclonal antibodies localize events in the folding, assembly, and intracellular transport of the influenza virus hemagglutinin glycoprotein. Cell. 52:843.
30. Steinman, R.M., B. Gutchinov, M.D. Witmer, and M.C. Nus-senzweig. 1983. Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice. J. Exp. Med. 157:613.
31. Inaba, K., R.M. Steinman, W.C. Van Voorhis, and S. Muramatsu. 1983. Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and man. Proc Natl. Acad. Sci. USA. 80:6041.
32. Matlin, K.S., H. Reggio, A. Helenius, and K. Simons. 1981. Infectious entry pathway of influenza virus in a canine kidney cell line. J. Cell Biol. 91:601.
33. Inaba, K., and R.M. Steinman. 1984. Resting and sensitized T lymphocytes exhibit distinct stimulatory (antigen-processing cell) requirements for growth and lymphokine release. J. Exp. Med. 160:1717.
34. Fetten, J.V., N. Roy, and E. Gilboa. 1991. A frameshift mutation at the NH2 terminus of the nucleoprotein gene does not affect generation of cytotoxic T lymphocyte epitopes. J. Immunol. 147:2697.
35. Ming, J.E., R.M. Steinman, and A. Granelli-Piperno. 1992. Interleukin 6 enhances the generation of CTL in the allogenic mixed leukocyte reaction. Clin. Exp Immunol. In press.
36. Inaba, K., A. Granelli-Pipemo, and R.M. Steinman. 1983. Dendritic cells induce T lymphocytes to release B cell-stimulating factors by an interleukin 2-dependent mechanism. Exp Med. 158:2040.
37. Townsend, A., and H. Bodmer. 1989. Antigen recognition by class I-restricted T lymphocytes. Annu. Rev. Immunol. 7:601.
38. Braciale, T.J., and K.L. Yap. 1978. Role of viral infectivity in the induction of influenza virus-specific cytotoxic T cells. Exp Med. 147:1236.
39. Nair, S., F. Zhou, R. Reddy, L. Huang, and B.T. Rouse. 1992. Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro. J. Exp Med. 175:609.
40. Ashman, R.B., and A. Mullbacher. 1979. A T helper cell for anti-viral cytotoxic T-cell responses. J. Exp Med. 150:1277.
41. Zinkemagel, R.M., G.N. Callahan, A. Althage, S. Cooper, J.W. Streilein, and J. Klein. 1978. The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help.J. Exp Med. 147:897.
42. Kast, M., A.M. Bronkhorst, L.R deWaal, and C.J.M. Melief. 1986. Cooperation between cytotoxic and helper T lymphocytes in protection against lethal sendai virus infection.J. Exp Med. 164:723.
43. Leist, I.P., M. Kohler, and R.M. Zinkemagel. 1989. Impaired generation of anti-viral cytotoxicity against lymphocytic choriomeningitis and vaccinia virus in mice treated with CD4-specific monoclonal antibody. Scand. J. Immunol. 30:679.
44. + and Lyt 2* T cell subsets in the control of an acute herpes simplex vims infection of the skin and nervous system. J. Virol. 68:825.
45. + T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody responses. J. Virol. 62:2102.
46. Buller, M.L., K.L. Holmes, A. Hugin, T.N. Frederickson, and H.C. Morse III. 1987. Induction of cytotoxic T-cell response in vivo in the absence of CD4 helper cells. Nature (Lond.). 328:77.
47. + cells but markedly decreased helper cell activity in mice lacking CD4. Nature (Lond.). 353:180.
48. Andrus, L., A. Granelli-Piperno, and E. Reich. 1984. Cytotoxic T cells both produce and respond to interleukin 2.J. Exp Med. 159:647.
49. Mizuochi, T., S. Ono, T.R. Malek, and A. Singer. 1986. Characterization of two distinct primary T cell populations that secrete interleukin 2 upon recognition of class I or class II major histocompatibility antigens. /. Exp Med. 163:603.
50. Klein, J.R., D.H. Raulet, M.S. Pasternack, and M.J. Bevan. 1982. Cytotoxic T lymphocytes produce immune interferon in response to antigen or mitogen. J. Exp Med. 155:1198.
51. Wysocka, M., and J.P. Bennink. 1988. Limiting dilution analysis of memory cytotoxic T lymphocytes specific for individual influenza virus gene products. Cell. Immunol. 112:425.
52. Owen, J.A., K.I. Dudzik, L. Klein, and D.R. Dorer. 1988. The kinetics of generation of influenza-specific cytotoxic T-lymphocyte precursor cells. Cell. Immunol. 111:247.
53. Deres, K., H. Schild, K.-H. Wiesmuller, G. Jung, and H.-G. Rammensee. 1989. In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine. Nature (Lond.). 342:561.
54. Carbone, F.R., and M.J. Bevan. 1989. Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization.J. Exp Med. 169:603.
55. Watari, E., B. Dietzschold, G. Szokan, and E. Heber-Katz. 1987. A synthetic peptide induces long-term protection from lethal infection with herpes simplex vims 2. J. Exp Med. 165:459.
56. + T cell help.J. Immunol. 147:4069.
57. Gao, X.-M., B. Zheng, F.Y. Liew, S. Brett, and J. Tite. 1991. Priming of influenza virus-specific cytotoxic T lymphocytes in vivo by short synthetic peptides. J. Immunol. 147:3268.
58. Hurwitz, J.L., C.J. Hackett, E.C. McAndrew, and W. Gerhard. 1985. Murine TH response to influenza vims: recognition of hemagglutinin, neuraminidase, matrix, and nucleoproteins.J. Immunol. 134:1994.
59. Mills, K.H.G., J.J. Skehel, and D.B. Thomas. 1986. Extensive diversity in the recognition of influenza vims hemagglutinin by murine T helper clones. J. Exp Med. 163:1477.
60. Burt, D.S., K.H.G. Mills, J.J. Skehel, and D.B. Thomas. 1989. Diversity of the class II (I-Ak/I-Ek)-restricted T cell repertoire for influenza hemagglutinin and antigenic drift.J. Exp Med. 170:383.
61. Ennis, F.A., M.A. Wells, G.M. Butchko, and P. Albrecht. 1978. Evidence that cytotoxic T cells are part of the host response to influenza pneumonia. J. Exp Med. 148:1241.
62. Holt, P.G., M.A. Schon-Hegrad, and J. Oliver. 1987. MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations. J. Exp Med. 167:262.
63. Schon-Hegrad, M.A., J. Oliver, P.G. McMenamin, and P.G. Holt. 1991. Studies on the density, distribution, and surface phenotype of intraepithélial class II major histocompatibility complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways. J. Exp Med. 173:1345.
64. Austyn, J.M., J.W. Kupiec-Weglinski, D.F. Hankins, and P.J. Morris. 1988. Migration patterns of dendritic cells in the mouse. Homing to T cell-dependent areas of spleen, and binding within marginal zone. J. Exp Med. 167:646.
65. Russell, S.M., and F.Y. Liew. 1979. T cells primed by influenza virion internal components can cooperate in the antibody response to haemagglutinin. Nature (Land.). 280:147.