Faster superoxide dismutase mutants designed by enhancing electrostatic guidance

Nature

Volumn 358, Issue 6384, 1992, Pages 347-351

  Getzoff, Elizabeth D ^a   Cabelli, Diane E ^b   Fisher, Cindy L ^a   Parge, Hans E ^a   Viezzoli, Maria Silvia ^c   Banci, Lucia ^c   Hallewell, Robert A ^a,d  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b BROOKHAVEN NATIONAL LABORATORY   (United States)

^c UNIVERSITY OF FLORENCE   (Italy)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; SUPEROXIDE DISMUTASE;

ARTICLE; HUMAN; MUTANT; OXIDATION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; COMPUTER SIMULATION; ELECTROCHEMISTRY; GLUTAMATES; GLUTAMIC ACID; HUMAN; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; KINETICS; LYSINE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OSMOLAR CONCENTRATION; PROTEIN CONFORMATION; SUPEROXIDE DISMUTASE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026749389     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/358347a0     Document Type: Article

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