Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 89, Issue 14, 1992, Pages 6403-6407

  Kato, Kiyoko ^a,b   Cox, Adrienne D ^a,c   Hisaka, Mark M ^a,c   Graham, Suzanne M ^a,c   Buss, Janice E ^a   Der, Channing J ^a,c  

^a BURNHAM INSTITUTE   (United States)

^b KYUSHU UNIVERSITY   (Japan)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

CAAX motif; Carboxyl methylation; Farnesylation

Indexed keywords

MAMMALIA;

ISOPRENOID;

AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL FREE SYSTEM; CELL TRANSFORMATION; GENETIC TRANSFECTION; METHYLATION; MUTATION; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MODIFICATION;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMAL; CELL COMPARTMENTATION; CELL MEMBRANE; CELL TRANSFORMATION, NEOPLASTIC; ENDOPEPTIDASES; FARNESOL; METHYLATION; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEIN P21(RAS); SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026747866     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.89.14.6403     Document Type: Article

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