The Amygdala Is Essential for the Expression of Conditional Hypoalgesia

Behavioral Neuroscience

Volumn 106, Issue 3, 1992, Pages 518-528

  Helmstetter, Fred J ^a  

^a UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FORMALDEHYDE; IBOTENIC ACID;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; AVERSIVE BEHAVIOR; BRAIN INJURY; CONDITIONED REFLEX; CONFERENCE PAPER; CONTROLLED STUDY; DEFENSIVE BEHAVIOR; FEMALE; NONHUMAN; RAT; STRESS;

AMYGDALA; ANIMAL; AROUSAL; BRAIN MAPPING; CONDITIONING, CLASSICAL; ELECTROSHOCK; FEAR; FEMALE; MOTOR ACTIVITY; NEURAL PATHWAYS; NEURONS; NOCICEPTORS; RATS; SENSORY THRESHOLDS; SOCIAL ENVIRONMENT; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SYNAPTIC TRANSMISSION;

EID: 0026747754     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/0735-7044.106.3.518     Document Type: Article

References (45)

1. Adams D.B. Brain mechanisms of offense, defense and submission. Behavioral and Brain Sciences 2 (1979) 201-241
2. Applegate C.D., Kapp B.S., Underwood M.D., and McNall C.L. Autonomic and somatomotor effects of amygdala central n. stimulation in awake rabbits. Physiology and Behavior 31 (1983) 353-360
3. Basbaum A.I., and Fields H.L. Endogenous pain control mechanisms: Review and hypothesis. Annals of Neurology 4 (1978) 451-462
4. Basbaum A.I., and Fields H.L. Endogenous pain control systems: Brainstem spinal pathways and endorphin circuitry. Annual Review of Neuroscience 7 (1984) 309-338
5. Blanchard D.C., and Blanchard R.J. Innate and conditioned reactions to threat in rats with amygdaloid lesions. Journal of Comparative and Physiological Psychology 81 (1972) 281-290
6. Blanchard R.J., and Blanchard D.C. Ethoexperimental approaches to the biology of emotion. Annual Review of Psychology 39 (1988) 43-68
7. Bodnar R.J. Neuropharmacological and neuroendocrine substrates of stress-induced analgesia. Annals of the New York Academy of Sciences 467 (1986) 345-360
8. Chance W.T., Krynock G.M., and Rosecrans J.A. Antinociception following lesion-induced hyperemotionality and conditioned fear. Pain 4 (1978) 243-252
9. Davis M., Hitchcock J.M., and Rosen J.B. Anxiety and the amygdala: Pharmacological and anatomical analysis of the fear potentiated startle paradigm. In: Bower G.H. (Ed). The psychology of learning and motivation vol. 21 (1987), Academic Press, San Diego, CA 263-305
10. de Olmos J., Alheid G.F., and Beltramino C.A. Amygdala. In: Paxinos G. (Ed). The rat nervous system: I. Forebrain and midbrain (1985), Academic Press, San Diego, CA 223-334
11. Dubuisson D., and Dennis S.G. The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stimulation in rats and cats. Pain 4 (1977) 161-174
12. Fanselow M.S. Shock-induced analgesia on the formalin test: Effects of shock severity, naloxone, hypophysectomy and associative variables. Behavioral Neuroscience 98 (1984) 79-95
13. Fanselow M.S. Conditioned fear-induced opiate analgesia: A competing motivational state theory of stress induced analgesia. Annals of the New York Academy of Sciences 467 (1986) 40-54
14. Fanselow M.S., and Helmstetter F.J. Conditional analgesia, defensive freezing and benzodiazepines. Behavioral Neuroscience 102 (1988) 233-243
15. Gentile C.G., Jarrell T.W., Teich A., McCabe P.M., and Schneiderman N. The role of the amygdaloid central nucleus in the retention of differential Pavlovian conditioning of bradycardia in rabbits. Behavioural Brain Research 20 (1986) 263-273
16. Grau J.W., Salinas J.A., Illich P.A., and Meagher M.W. Associative learning and memory of an antinociceptive response in the spinalized rat. Behavioral Neuroscience 104 (1990) 489-494
17. Grossman S.P., Grossman L., and Walsh L. Functional organization of the rat amygdala with respect to avoidance behavior. Journal of Comparative and Physiology Psychology 88 (1975) 829-850
18. Hayes R.L., Bennet G.J., Newlon P.G., and Mayer D.J. Behavioral and physiological studies of non-narcotic analgesia in the rat elicited by certain environmental stimuli. Brain Research 155 (1978) 69-90
19. Helmstetter F.J., Calcagnetti D.J., and Fanselow M.S. The β-carboline, DMCM, produces analgesia after central administration. Psychobiology 18 (1990) 293-297
20. Helmstetter F.J., and Fanselow M.S. Effects of naltrexone on the learning and performance of conditional fear-induced freezing and opioid analgesia. Physiology and Behavior 39 (1987) 501-505
21. Helmstetter F.J., and Landeira-Fernandez J. Conditional hypoalgesia is attenuated by naltrexone applied to the PAG. Brain Research 537 (1990) 88-92
22. Hitchcock J.M., and Davis M. Fear-potentiated startle using an auditory conditioned stimulus: Effect of lesions of the amygdala. Physiology and Behavior 39 (1987) 403-409
23. Hitchcock J.M., Sananes C.B., and Davis M. Sensitization of the startle reflex by footshock: Blockade by lesions of the central nucleus of the amygdala or its efferent pathway to the brainstem. Behavioral Neuroscience 103 (1989) 509-518
24. Hopkins A., and Holstege G. Amygdaloid projections to the mesencephalon, pons and medulla oblonggata in the cat. Experimental Brain Research 32 (1978) 529-547
25. Iwata J., Chida K., and LeDoux J.E. Cardiovascular responses elicited by stimulation of neurons in the central amygdaloid nucleus in awake but not anesthetized rats resemble conditioned emotional responses. Brain Research 418 (1987) 183-188
26. Iwata J., LeDoux J.E., Meeley M.P., Arneric S., and Reis D.J. Intrinsic neurons in the amygdaloid field projected to by the medial geniculate body mediate emotional responses conditioned to acoustic stimuli. Brain Research 371 (1986) 395-399
27. Jellestad F.K., and Bakke H.K. Passive avoidance after ibotenic acid and radio frequency lesions in the rat amygdala. Physiology and Behavior 34 (1985) 299-305
28. Kapp B.S., Frysinger R.C., Gallagher M., and Haselton J. Amygdala central nucleus lesions: Effects on heart rate conditioning in the rabbit. Physiology and Behavior 23 (1979) 1109-1117
29. Kinscheck I.B., Watkins L.R., and Mayer D.J. Fear is not critical to classically conditioned analgesia: The effects of periaqueductal gray lesions and administration of chlordiazepoxide. Brain Research 298 (1984) 33-44
30. Kohler C., and Schwartz R. Comparison of ibotenate and kainate neurotoxicity in rat brain: A histological study. Neuroscience 8 (1983) 819-835
31. Krettek J.E., and Price J.L. Amygdaloid projections to subcortical structures within the basal forebrain and brainstem in the rat and cat. Journal of Comparative Neurology 178 (1978) 225-254
32. LeDoux J.E., Cicchetti P., Xagoraris A., and Romanski L.M. The lateral amygdaloid nucleus: Sensory interface of the amygdala in fear conditioning. Journal of Neuroscience 10 (1990) 1062-1069
33. LeDoux J.E., Iwata J., Cicchetti P., and Reis D.J. Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear. Journal of Neuroscience 8 (1988) 2517-2529
34. LeDoux J.E., Ruggiero D.A., and Reis D.J. Projections to the subcortical forebrain from anatomically defined regions of the medial geniculate body in the rat. Journal of Comparative Neurology 242 (1985) 182-213
35. Miczek K.A., Thompson M.L., and Shuster L. Naloxone injections into the periaqueductal gray and arcuate nucleus block analgesia in defeated mice. Psychopharmacology 87 (1985) 39-42
36. Miserendino M.J.D., Sananes C.B., Melia K.R., and Davis M. Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala. Nature 345 (1990) 716-718
37. Nagel J.A., and Kemble E.D. Effects of amygdaloid lesions on the performance of rats in four passive avoidance tasks. Physiology and Behavior 17 (1976) 245-250
38. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates. 2nd ed. (1986), Academic Press, San Diego, CA
39. Pellegrino L.J., Pellegrino A.S., and Cushman A.J. A stereotaxic atlas of the rat brain. 2nd ed. (1979), Plenum, New York
40. Riolobos A.S., and Martin Garcia A.I. Open field activity and passive avoidance responses in rats after lesion of the central amygdaloid nucleus by electro coagulation and ibotenic acid. Physiology and Behavior 39 (1987) 715-720
41. Rizvi T.A., Ennis M., Behbehani M.M., and Shipley M.T. Connections between the central nucleus of the amygdala and the midbrain periaqueductal gray: Topography and reciprocity. Journal of Comparative Neurology 303 (1991) 121-131
42. Terman G.W., Shavit Y., Lewis J.W., Cannon J.T., and Liebeskind J.C. Intrinsic mechanisms of pain inhibition: Activation by stress. Science 226 (1984) 1270-1277
43. Watkins L.R., and Mayer D.J. Organization of endogenous opiate and nonopiate pain control systems. Science 216 (1982) 1185-1192
44. Watkins L.R., and Mayer D.J. Multiple endogenous opiate and nonopiate analgesia systems: Evidence of their existence and clinical applications. Annals of the New York Academy of Sciences 467 (1986) 273-299
45. Watkins L.R., Cobelli D.A., and Mayer D.J. Classical conditioning of front paw and hind paw footshock induced analgesia (FSIA): Naloxone reversibility and descending pathways. Brain Research 243 (1982) 119-132