Cis-acting sequences regulating expression of the human α-globin cluster lie within constitutively open chromatin

Cell

Volumn 69, Issue 5, 1992, Pages 781-793

  Vyas, P ^a   Vickers, M A ^a   Simmons, D L ^a   Ayyub, H ^a   Craddock, C F ^a   Higgs, D R ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLOBIN; BETA GLOBIN;

ANIMAL CELL; ARTICLE; CHROMATIN STRUCTURE; ERYTHROID CELL; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENE STRUCTURE; GLOBIN SYNTHESIS; HUMAN; HUMAN CELL; INTRON; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

ANIMAL; BLOTTING, NORTHERN; CELL LINE; CHROMATIN; DEOXYRIBONUCLEASE I; GENE EXPRESSION REGULATION; GLOBINS; HUMAN; INTRONS; METHYLATION; MULTIGENE FAMILY; REGULATORY SEQUENCES, NUCLEIC ACID; REPETITIVE SEQUENCES, NUCLEIC ACID; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0026747665     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(92)90290-S     Document Type: Article

References (92)

1. Controlled synthesis of HBsAg in a differentiated human liver carcinoma derived cell line
2. Theta, zeta and epsilon globin messenger RNAs are expressed in adults
3. DNase I sensitive domain of the gene coding for the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase
4. DNA and chromatin structure of the human α1(I) collagen gene
5. Mammalian chromosome banding — an expression of genome organization
6. CpG-rich islands and the function of DNA methylation
7. Non-methylated CpG-rich islands at the human α-globin locus: implications for evolution of the α-globin pseudogene
8. The β-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner
9. A domain model for eukaryotic DNA organization: a molecular basis for cell differentiation and chromosome evolution
10. Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice
11. Genetic activity along 315 kb of the Drosophila chromosome
12. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
13. Genomic sequencing
14. Cloning and nucleotide sequence analysis of human embryonic ζ-globin cDNA
15. Mechanisms of chromosome banding and implications for chromosome structure
16. Activation and repression of a β-globin gene in cell hybrids is accompanied by a shift in its temporal replication
17. Enhancer sequences located 3′ of the mouse immunoglobulin λ locus specify high-level expression of an immunoglobulin λ gene in B cells of transgenic mice
18. Boundary functions in the control of gene expression
19. Chromatin structure and gene activity
20. Asynchronous DNA replication within the human β-globin gene locus
21. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity
22. Long range genome structure around the human α-globin complex analysed by PFGE
23. Unusual features of CpG-rich (HTF) islands in the human α-globin complex association with non-functional pseudogenes and presence within the 3′ portion of the ζ gene
24. New human cell lines
25. A developmentally stable chromatin structure in the human β-globin gene cluster
26. Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids
27. A deletion of the human β-globin locus activation region causes a major alteration in chromatin structure and replication across the entire β-globin locus
28. Interrelationship between differentiation and malignancy-associated properties in glioma
29. CpG islands in vertebrate genomes
30. A glimpse at chromosomal order
31. Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium
32. Replication timing of genes and middle repetitive sequences
33. Characteristics of a human cell line transformed by DNA from human adenovirus type 5
34. Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice
35. Nuclease hypersensitive sites in chromatin
36. Position-independent high-level expression of the human β-globin gene in transgenic mice
37. A novel enhancer in the immunoglobulin λ locus is duplicated and functionally independent of NFκB
38. Transcripts, genes and bands in 315,000 base pairs of Drosophila DNA
39. Importance of globin gene order for correct developmental expression
40. New genes in the class II region of the human major histocompatibility complex
41. α-Thalassemia caused by a large (62 kb) deletion upstream of the human α-globin gene cluster
42. Gene within a gene: nested Drosophila genes encode unrelated proteins on opposite DNA strarids
43. A review of the molecular genetics of the human α-globin gene cluster
44. A major positive regultory region located far upstream of the human α-globin gene locus
45. Role of replication time in the control of tissue-specific gene expression
46. Characterization of Giemsa dark- and light-band DNA
47. 1 globin gene
48. The mouse surfeit locus contains a cluster of six genes associated with four CpG-rich islands in 32 kilobases of genomic DNA
49. Structure-function relationships in eukaryotic nuclei
50. The DNase I sensitive domain of the chicken lysozyme gene spans 24 kb
51. A new hypervariable marker for the human α-globin gene cluster
52. Nuclear scaffold attachment sites in the human globin gene complexes
53. Sites of attachment to the nuclear scaffold in the human α and β-globin gene complexes
54. Characterization of the major regulatory element upstream of the human α-globin gene cluster
55. A position-effect assay for boundaries of higher order chromosomal domains
56. β-Globin gene inactivation by DNA translocation in γβ-thalassaemia
57. Surface IgM specificity on cells derived from a Burkitt's lymphoma
58. The chromosomal arrangement of human α-like globin genes: sequence homology and α-globin gene deletions
59. Deoxyribonuclease I sensitivity of the nontranscribed sequences flanking the 5′ and 3′ ends of the ovomucoid gene and the ovalbumin and its related X and Y genes in hen oviduct nuclei
60. Definition of 5′ and 3′ structural boundaries of the chromatin domain containing the ovalbumin multigene family
61. New human cancer cell culture lines. I. SW-13, small-cell carcinoma of the adrenal cortex
62. Transcriptional and translational analysis of the human θ globin gene
63. A transcribed gene in an intron of the human factor VIII gene
64. Inactivation of human α-globin gene expression by a de novo deletion located upstream of the α-globin gene cluster
65. Use of restriction enzymes to detect potential gene sequences in mammalian DNA
66. Human chronic myelogenous leukaemia cell-line with positive Philadelphia chromosome
67. HEL cells: a new human erythroleukaemia cell line with spontaneous and induced globin expression
68. The establishment and characterization of a cell line and mouse xenografts from a human malignant melanoma
69. The immunoglobulin χ locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region
70. Genes and loops in 320,000 base pairs of the Drosophila melanogaster genome
71. Recombination at the human α-globin gene cluster: sequence features and topological constraints
72. Gene analysis
73. Haemoglobin switching in human embryos: asynchrony of ζ → α and ε → γ-globin switches in primitive and definitive erythropoietic lineage
74. A second B cell-specific enhancer 3′ of the immunoglobulin heavy-chain locus
75. α-Thalassernia resulting from deletion of regulatory sequences far upstream of the α-globin structural genes
76. Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region
77. LFA-3 is a phospholipid linked membrane protein homologous to its ligand CD2
78. Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system
79. A new cluster of genes within the human major histocompatibility complex
80. Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B
81. A nuclear DNA attachment element mediates elevated and position-independent gene activity
82. Alternative chromatin structure at CpG islands
83. Cloned human teratoma cells differentiate into neuron-like cells and other cell types in retinoic acid
84. Human globin locus activation region (LAR): role in temporal control
85. The ‘β-like globin’ gene domain in human erythroid cells
86. Type I neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients
87. n
88. Stable length polymorphism of up to 260 kb at the tip of the short arm of human chromosome 16
89. A mouse locus at which transcription from both DNA strands produces mRNAs complementary at their 3′ ends
90. Nucleotide sequence of the coding portion of human α-globin messenger RNA
91. Chromatin structure and developmental expression of the human α-globin cluster