Reduced Leydig cell volume and function in adult rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin without a significant effect on spermatogenesis

Toxicology

Volumn 76, Issue 2, 1992, Pages 103-118

  Johnson, Larry ^a   Dickerson, Richard ^a   Safe, Stephen H ^a   Nyberg, Chris L ^a   Lewis, Richard P ^a   Welsh Jr , Thomas H ^b  

^a TEXAS A AND M UNIVERSITY   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin; Epididymis; Leydig cell; Spermatogenesis

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ANDROGEN RECEPTOR; ANDROSTANOLONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VOLUME; CONTROLLED STUDY; DOSE RESPONSE; EPIDIDYMIS; INTRAPERITONEAL DRUG ADMINISTRATION; LEYDIG CELL; MALE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RAT; SPERMATOGENESIS; TESTOSTERONE BLOOD LEVEL;

ANIMAL; BODY WEIGHT; CELL COUNT; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIDIDYMIS; LEYDIG CELLS; MALE; MICROSCOPY, ELECTRON; ORGAN WEIGHT; PROSTATE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANDROGEN; SEMINAL VESICLES; SPERMATOGENESIS; SPERMATOZOA; TESTIS; TESTOSTERONE; TETRACHLORODIBENZODIOXIN;

EID: 0026739968     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(92)90158-B     Document Type: Article

References (47)

1. PCCDs and PCDFs: Sources and environmental impact
2. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity
3. The regulation of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin
4. Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans
5. Mechanism of action
6. Results of a 2-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats
7. Response of chickens to prolonged feeding of crude toxic fat
8. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated depression of rat testicular heme synthesis and microsomal cytochrome P-450
9. Depression of rat testicular 17-hydroxylase and 17,20-lyase after administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
10. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on testosterone (T) production by isolated perfused testes
11. Inhibition of testicular steroidogenesis in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats: Evidence that the key lesion occurs prior to or during pregnenolone formation
12. Androgenic deficiency in male rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin
13. Androgen catabolism and excretion in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats
14. Effect of seasonal changes in Leydig cell number on the volume of smooth endoplasmic reticulum in Leydig cells and intratesticular testosterone content in stallions
15. Sperm production rates
16. Daily sperm production and epididymal sperm reserves of pubertal and adult rats
17. Synthesis and Ah receptor binding properties of radiolabeled polychlorinated dibenzofuran congeners
18. A comparative study of daily sperm production and testicular composition in humans and rats
19. Germ cell degeneration in normal and microwave-irradiated rats: Potential sperm production rates at different developmental steps in spermatogenesis
20. Definition of the stages of the cycle of the seminiferous epithelium in the rat
21. Effect of daily spermatozoan production but not age on transit time of spermatozoa through the human epididymis
22. Method for the quantitative morphologic analysis of tissues
23. Seasonal variation in the total volume of Leydig cells in stallions is explained by variation in cell number rather than cell size
24. Phorbol ester inhibition of ovarian and testicular steroidogenesis in vitro
25. Direct biphasic modulation of gonadotropin-stimulated testicular androgen biosynthesis by prolactin
26. Effects of estradiol-17 alpha on nuclear occupancy of the estrogen receptor, stimulation of nuclear type II sites and uterine growth
27. Comparative activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and progesterone as antiestrogens in the female rat uterus
28. Protein measurement with the Folin phenol reagent
29. Competitive binding to the cytosolic 2,3,7,8-TCDD receptor: Effects of structure on the affinities of substituted biphenyls — a QSAR approach
30. Light and electron microscopic observations in Macaca mulatta monkeys fed toxic fat
31. Increased incidence of neoplasms in rats exposed to low levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin
32. The comparative toxicity of chlorinated dibenzo-p-dioxins in mice and guinea pigs
33. The male reproductive system is highly sensitive to in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure
34. Effects of perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on the development of male rats and their androgenic status
35. The effect of a 5 alpha-reductase inhibitor on androgen physiology in the immature male rat
36. The androgen status of aging male rats
37. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): Results of a 13-week oral toxicity study in rats
38. Polychloridibenzo-p-dioxins: Perinatal effects and the dominant lethal test in Wistar rats
39. Maintenance of advanced spermatogenic cells in the adult rat testis: Quantitative relationship to testosterone concentration within the testis
40. Effect of age and dietary restriction on daily sperm production and number and transit time of epididymal spermatozoa in the mouse
41. Plasma concentrations of pituitary hormones in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated male rats
42. The effect of total parenteral nutrition on the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat
43. 3H-thymidine incorporation of epididymal principal cells in adult Syrian hamsters
44. Age-related change in numbers of other interstitial cells in testes of adult men: Evidence bearing on the fate of Leydig cells lost with increasing age
45. Testosterone secretion by rat, rabbit, guinea pig, dog and hamster testes perfused in vitro: Correlation with Leydig cell ultrastructure
46. Leydig cell cytoplasmic content is related to daily sperm production in men