메뉴 건너뛰기




Volumn 52, Issue 19, 1992, Pages 5144-5153

Micropharmacology of Monoclonal Antibodies in Solid Tumors: Direct Experimental Evidence for a Binding Site Barrier

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY;

EID: 0026739369     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (378)

References (43)
  • 1
    • 84969052861 scopus 로고
    • Studies on the exchange of fluids between host and tumor. II. The blood flow of hepatomas and other tumors in rats and mice
    • Gullino, P. M., and Grantham, F. H. Studies on the exchange of fluids between host and tumor. II. The blood flow of hepatomas and other tumors in rats and mice. J. Natl. Cancer Inst., 42: 771-782, 1969.
    • (1969) J. Natl. Cancer Inst. , vol.42 , pp. 771-782
    • Gullino, P.M.1    Grantham, F.H.2
  • 2
    • 0017248152 scopus 로고
    • An experimental study in rat with a comparison of different methods for estimation of tumor blood flow
    • Kjartansson, I. An experimental study in rat with a comparison of different methods for estimation of tumor blood flow. Acta Chir. Scand. Suppl., 471: 1-74, 1976.
    • (1976) Acta Chir. Scand. Suppl. , vol.471 , pp. 1-74
    • Kjartansson, I.1
  • 3
    • 84901964707 scopus 로고
    • Antigenic heterogeneity, modulation and evolution in breast cancer lesions as defined by monoclonal antibodies
    • In: M. Rich, J. C. Hager, and P. Furmanski (eds.), New York: Marcel Dekker, Inc.
    • Schlom, J., Colcher, D., Hand, P. H., Wunderlich, D., Nuti, M., and Tera-moto, Y. A. Antigenic heterogeneity, modulation and evolution in breast cancer lesions as defined by monoclonal antibodies. In: M. Rich, J. C. Hager, and P. Furmanski (eds.), Understanding Breast Cancer. Clinical and Laboratory Concepts, pp. 315-358. New York: Marcel Dekker, Inc., 1983.
    • (1983) Understanding Breast Cancer. Clinical and Laboratory Concepts , pp. 315-358
    • Schlom, J.1    Colcher, D.2    Hand, P.H.3    Wunderlich, D.4    Nuti, M.5    Tera-moto, Y.A.6
  • 4
    • 0022531368 scopus 로고
    • Autoradiographic analysis of monoclonal antibody distribution in human colon and breast tumor xenografts
    • Jones, P. L., Gallagher, B. M., and Sands, H. Autoradiographic analysis of monoclonal antibody distribution in human colon and breast tumor xenografts. Cancer Immunol. Immunother., 22: 139-143, 1986.
    • (1986) Cancer Immunol. Immunother. , vol.22 , pp. 139-143
    • Jones, P.L.1    Gallagher, B.M.2    Sands, H.3
  • 5
    • 0023195012 scopus 로고
    • Regional localization of a glioma-associated antigen defined by monoclonal antibody 81C6 in vivo: kinetics and implications for diagnosis and therapy
    • Blasberg, R. G., Nakagawa, H., Bourdon, M. A., Groothuis, D. R., Patlak, C. S., and Binger, D. D. Regional localization of a glioma-associated antigen defined by monoclonal antibody 81C6 in vivo: kinetics and implications for diagnosis and therapy. Cancer Res., 47:4432-4443, 1987.
    • (1987) Cancer Res. , vol.47 , pp. 4432-4443
    • Blasberg, R.G.1    Nakagawa, H.2    Bourdon, M.A.3    Groothuis, D.R.4    Patlak, C.S.5    Binger, D.D.6
  • 6
    • 0023906184 scopus 로고
    • Correlation of vascular permeability and blood flow with monoclonal antibody uptake by human Clouser and renal cell xenografts
    • Sands, H., Jones, P. L., Shah, S. A., Palme, D., Vessella, R. L., and Gallagher, B. M. Correlation of vascular permeability and blood flow with monoclonal antibody uptake by human Clouser and renal cell xenografts. Cancer Res., 48: 188-193, 1988.
    • (1988) Cancer Res. , vol.48 , pp. 188-193
    • Sands, H.1    Jones, P.L.2    Shah, S.A.3    Palme, D.4    Vessella, R.L.5    Gallagher, B.M.6
  • 7
    • 0024232289 scopus 로고
    • Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure
    • Jain, R. K., and Baxter, L. T. Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure. Cancer Res., 48: 7022-7032, 1988.
    • (1988) Cancer Res. , vol.48 , pp. 7022-7032
    • Jain, R.K.1    Baxter, L.T.2
  • 8
    • 0023788067 scopus 로고
    • Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules
    • Dvorak, H. F., Nagy, J. A., Dvorak, J. T., and Dvorak, A. M. Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules. Am. J. Pathol., 133:95-109, 1988.
    • (1988) Am. J. Pathol. , vol.133 , pp. 95-109
    • Dvorak, H.F.1    Nagy, J.A.2    Dvorak, J.T.3    Dvorak, A.M.4
  • 9
    • 0023821419 scopus 로고
    • Measurement of local Mr 97,000 and 250,000 protein antigen concentration in sections of human melanoma tumor using in vitro quantitative autoradiography
    • Del Vecchio, S., Reynolds, J. C., Blasberg, R. G., Neumann, R. D., Carrasquillo, J. A., Hellstrom, I., and Larson, S. M. Measurement of local Mr 97,000 and 250,000 protein antigen concentration in sections of human melanoma tumor using in vitro quantitative autoradiography. Cancer Res., 48: 5475-5481, 1988.
    • (1988) Cancer Res. , vol.48 , pp. 5475-5481
    • Del Vecchio, S.1    Reynolds, J.C.2    Blasberg, R.G.3    Neumann, R.D.4    Carrasquillo, J.A.5    Hellstrom, I.6    Larson, S.M.7
  • 11
    • 0024584819 scopus 로고
    • Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection
    • Baxter, L. T., and Jain, R. K. Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection. Microvasc. Res., 37: 77-104, 1989.
    • (1989) Microvasc. Res. , vol.37 , pp. 77-104
    • Baxter, L.T.1    Jain, R.K.2
  • 12
    • 13344259485 scopus 로고
    • Monoclonal antibody therapy of solid tumors
    • In: K. A. Foon and A. C. Morgan, Jr. (eds.), Boston: Martinus Nijhoff
    • Abrams, P. G., and Oldham, R. K. Monoclonal antibody therapy of solid tumors. In: K. A. Foon and A. C. Morgan, Jr. (eds.), Monoclonal Antibody Therapy of Human Cancer, pp. 103-120. Boston: Martinus Nijhoff, 1985.
    • (1985) Monoclonal Antibody Therapy of Human Cancer , pp. 103-120
    • Abrams, P.G.1    Oldham, R.K.2
  • 15
    • 0024433856 scopus 로고
    • Modeling analysis of the global and microscopic distribution of IgG, F(ab')2, and Fab in tumors
    • Fujimori, K., Covell, D. C., Fletcher, J. E., and Weinstein, J. N. Modeling analysis of the global and microscopic distribution of IgG, F(ab')2, and Fab in tumors. Cancer Res., 49: 5656-5663, 1989.
    • (1989) Cancer Res. , vol.49 , pp. 5656-5663
    • Fujimori, K.1    Covell, D.C.2    Fletcher, J.E.3    Weinstein, J.N.4
  • 16
    • 0024238235 scopus 로고
    • Localization of monoclonal antibody AUAI and its F(ab2 fragments in human tumour xenografts: an autoradiographic and immunohistochemical study
    • (Suppl.)
    • Pervez, S., Epenetos, A. A., Mool, W. J., Evans, D. J., Rowlinson, G., Dhokia, B., and Krausz, T. Localization of monoclonal antibody AUAI and its F(ab2 fragments in human tumour xenografts: an autoradiographic and immunohistochemical study. Int. J. Cancer, 3 (Suppl.); 23-29, 1988.
    • (1988) Int. J. Cancer , vol.3 , pp. 23-29
    • Pervez, S.1    Epenetos, A.A.2    Mool, W.J.3    Evans, D.J.4    Rowlinson, G.5    Dhokia, B.6    Krausz, T.7
  • 17
    • 0025065107 scopus 로고
    • Transport of fluid and macromolecules in tumors II. Role of heterogeneous perfusion and lymphatics
    • Baxter, L. T., and Jain, R. K. Transport of fluid and macromolecules in tumors II. Role of heterogeneous perfusion and lymphatics. Microvasc. Res., 40: 246-263, 1991.
    • (1991) Microvasc. Res. , vol.40 , pp. 246-263
    • Baxter, L.T.1    Jain, R.K.2
  • 18
    • 0024311902 scopus 로고
    • Penetration and binding of antibodies in experimental human solid tumors grown in mice
    • Ong, G. L., and Mattes, M. J. Penetration and binding of antibodies in experimental human solid tumors grown in mice. Cancer Res., 49: 4264-4273, 1989.
    • (1989) Cancer Res. , vol.49 , pp. 4264-4273
    • Ong, G.L.1    Mattes, M.J.2
  • 20
    • 0026531995 scopus 로고
    • The macroscopic and microscopic pharmacology of monoclonal antibodies
    • Weinstein, J. N., and van Osdol, W. The macroscopic and microscopic pharmacology of monoclonal antibodies. Int. J. Immunopharmacol., 14: 457-463, 1992.
    • (1992) Int. J. Immunopharmacol. , vol.14 , pp. 457-463
    • Weinstein, J.N.1    van Osdol, W.2
  • 21
    • 0025376171 scopus 로고
    • A modeling analysis of monoclonal antibody percolation through tumors: a binding site barrier
    • Fujimori, K., Covell, D. G., Fletcher, J. E., and Weinstein, J. N. A modeling analysis of monoclonal antibody percolation through tumors: a binding site barrier. J. Nucl. Med., 31: 1191-1198, 1990.
    • (1990) J. Nucl. Med. , vol.31 , pp. 1191-1198
    • Fujimori, K.1    Covell, D.G.2    Fletcher, J.E.3    Weinstein, J.N.4
  • 22
    • 0026425598 scopus 로고
    • Integrated microscopic-macroscopic pharmacology of monoclonal antibody radioconjugates: the radiation dose distribution
    • Fujimori, K., Fisher, D. R., and Weinstein, J. N. Integrated microscopic-macroscopic pharmacology of monoclonal antibody radioconjugates: the radiation dose distribution. Cancer Res., 51:4821-4827, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 4821-4827
    • Fujimori, K.1    Fisher, D.R.2    Weinstein, J.N.3
  • 23
    • 0026425576 scopus 로고
    • An analysis of monoclonal antibody distribution in microscopic tumor models: consequences of a “bind-ing-site barrier”
    • van Osdol, W., Fujimori, K., and Weinstein, J. N. An analysis of monoclonal antibody distribution in microscopic tumor models: consequences of a “bind-ing-site barrier”. Cancer Res., 51:4776-4784, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 4776-4784
    • van Osdol, W.1    Fujimori, K.2    Weinstein, J.N.3
  • 26
    • 0020503030 scopus 로고
    • Guinea pig line 10 hepatocarcinoma model: characterization of monoclonal antibody and in vivo effect of unconjugated antibody and antibody conjugated to diphtheria toxin A chain
    • Bernhard, M. I., Foon, K. A., Oeltmann, T. N., Key, M. E., Hwang, K. M., Gregory, C. C., Christensen, W. L., Hoyer, L. C., Hanna, M. G., Jr., and Oldham, R. K. Guinea pig line 10 hepatocarcinoma model: characterization of monoclonal antibody and in vivo effect of unconjugated antibody and antibody conjugated to diphtheria toxin A chain. Cancer Res., 43: 4420-4428, 1983.
    • (1983) Cancer Res. , vol.43 , pp. 4420-4428
    • Bernhard, M.I.1    Foon, K.A.2    Oeltmann, T.N.3    Key, M.E.4    Hwang, K.M.5    Gregory, C.C.6    Christensen, W.L.7    Hoyer, L.C.8    Hanna, M.G.9    Oldham, R.K.10
  • 27
    • 0014302846 scopus 로고
    • Antigenicity of a new diethylnitrosamine-induced transplantable guinea pig hepatoma: pathology and formation of ascites variant
    • Rapp, H. J., Churchill, W. H., Jr., Kronman, B. S., Rolley, R. T., Hammond, W. G., and Boros, T. Antigenicity of a new diethylnitrosamine-induced transplantable guinea pig hepatoma: pathology and formation of ascites variant. J. Natl. Cancer Inst., 41: 1-11, 1968.
    • (1968) J. Natl. Cancer Inst. , vol.41 , pp. 1-11
    • Rapp, H.J.1    Churchill, W.H.2    Kronman, B.S.3    Rolley, R.T.4    Hammond, W.G.5    Boros, T.6
  • 28
    • 0021745313 scopus 로고
    • Pathogenesis of tumor desmoplasia. 1. Immunofluorescence identification and localization of some structural proteins in line 1 and line 10 guinea pig tumors and in healing wounds
    • Dvorak, H. F., Form, D. M., Manseaun, E., and Smith, B. D. Pathogenesis of tumor desmoplasia. 1. Immunofluorescence identification and localization of some structural proteins in line 1 and line 10 guinea pig tumors and in healing wounds. J. Natl. Cancer Inst., 73: 1195-1205, 1984.
    • (1984) J. Natl. Cancer Inst. , vol.73 , pp. 1195-1205
    • Dvorak, H.F.1    Form, D.M.2    Manseaun, E.3    Smith, B.D.4
  • 29
    • 34547383713 scopus 로고
    • Preparation of iodine-131 labeled growth hormone of high specificity
    • Hunter, W. A., and Greenwood, F. C. Preparation of iodine-131 labeled growth hormone of high specificity. Nature (Lond.), 194:495-496, 1962.
    • (1962) Nature (Lond.) , vol.194 , pp. 495-496
    • Hunter, W.A.1    Greenwood, F.C.2
  • 32
    • 0019423594 scopus 로고
    • The use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase technique: a comparison between ABC and unlabeled antibody (PAP) procedures
    • Hsu, S. M., Raine, L., and Fanger, H. The use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase technique: a comparison between ABC and unlabeled antibody (PAP) procedures. J. Histochem. Cytochem., 29: 577-580, 1981.
    • (1981) J. Histochem. Cytochem. , vol.29 , pp. 577-580
    • Hsu, S.M.1    Raine, L.2    Fanger, H.3
  • 33
    • 33749871965 scopus 로고
    • The experimental study of tumor progression: a review
    • Foulds, L. The experimental study of tumor progression: a review. Cancer Res., 14: 327-339, 1957.
    • (1957) Cancer Res. , vol.14 , pp. 327-339
    • Foulds, L.1
  • 34
    • 0020699927 scopus 로고
    • Definition of antigenic heterogeneity and modulation among human mammary carcinoma cell populations using monoclonal antibodies to tumor-associated antigens
    • Hand, P. H., Nuti, N., Colcher, D., and Schlom, J. Definition of antigenic heterogeneity and modulation among human mammary carcinoma cell populations using monoclonal antibodies to tumor-associated antigens. Cancer Res., 43: 728-735, 1983.
    • (1983) Cancer Res. , vol.43 , pp. 728-735
    • Hand, P.H.1    Nuti, N.2    Colcher, D.3    Schlom, J.4
  • 35
    • 0025743924 scopus 로고
    • Uptake and distribution of specific and control monoclonal antibodies in subcutaneous xenografts following intratumor injection
    • Rowlinson-Busza, G., Bamias, A., Krausz, T., and Epenetos, A. A. Uptake and distribution of specific and control monoclonal antibodies in subcutaneous xenografts following intratumor injection. Cancer Research, 51: 3251-3256, 1991.
    • (1991) Cancer Research , vol.51 , pp. 3251-3256
    • Rowlinson-Busza, G.1    Bamias, A.2    Krausz, T.3    Epenetos, A.A.4
  • 36
    • 0023144781 scopus 로고
    • Penetration and binding of radiolabeled anti-carcinoembrionic antigen monoclonal antibodies and their antigen binding fragments in human colon mul-ticellular tumor spheroids.
    • Sutherland, R. Buchegger, F., Schreyer, M., Vacca, A., and Mach, J-P. Penetration and binding of radiolabeled anti-carcinoembrionic antigen monoclonal antibodies and their antigen binding fragments in human colon mul-ticellular tumor spheroids. Cancer Res., 47: 1627-1633, 1987.
    • (1987) Cancer Res. , vol.47 , pp. 1627-1633
    • Sutherland, R.1    Buchegger, F.2    Schreyer, M.3    Vacca, A.4    Mach, J.-P.5
  • 37
    • 0023895360 scopus 로고
    • Uptake kinetics of monoclonal antibody by human malignant melanoma multicell spheroids
    • Kwok, C. S., Cole, S. E., and Liao, S. K. Uptake kinetics of monoclonal antibody by human malignant melanoma multicell spheroids. Cancer Res., 48: 1856-1863, 1988.
    • (1988) Cancer Res. , vol.48 , pp. 1856-1863
    • Kwok, C.S.1    Cole, S.E.2    Liao, S.K.3
  • 38
    • 0025172844 scopus 로고
    • 1125-NRLU-10 kinetic studies and BISMUTH-212-NRLU-10 toxicity in LS174T multicell spheroids
    • Langmuir, V. K., Atcher, R. W., Hines, J. J., and Brechbiel, M. W. 1125-NRLU-10 kinetic studies and BISMUTH-212-NRLU-10 toxicity in LS174T multicell spheroids. J. Nucl. Med., 31: 1527-1533, 1990.
    • (1990) J. Nucl. Med. , vol.31 , pp. 1527-1533
    • Langmuir, V.K.1    Atcher, R.W.2    Hines, J.J.3    Brechbiel, M.W.4
  • 39
    • 44949284387 scopus 로고
    • The effect of antigen concentration, antibody valency and size, and tumor architecture on antibody binding in multicell spheroids
    • Langmuir, V. K., McGann, J. K., Buchegger, F., and Sutherland, R. M. The effect of antigen concentration, antibody valency and size, and tumor architecture on antibody binding in multicell spheroids. Intl. J. Rad. Appl. Instrum. BJ, 18: 753-764, 1992.
    • (1992) Intl. J. Rad. Appl. Instrum. BJ , vol.18 , pp. 753-764
    • Langmuir, V.K.1    McGann, J.K.2    Buchegger, F.3    Sutherland, R.M.4
  • 41
    • 0025858165 scopus 로고
    • The effect of antibody protein dose on the uniformity of tumor distribution of radioantibodies: an autoradiographic study
    • Blumenthal, R. D., Fand, I., Sharkey, R. M., Boerman, O. C., Kashi, R., and Goldenberg, D. M. The effect of antibody protein dose on the uniformity of tumor distribution of radioantibodies: an autoradiographic study. Cancer Immunol. Immunother., 33: 351-358, 1991.
    • (1991) Cancer Immunol. Immunother. , vol.33 , pp. 351-358
    • Blumenthal, R.D.1    Fand, I.2    Sharkey, R.M.3    Boerman, O.C.4    Kashi, R.5    Goldenberg, D.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.