Toxicity of synthetic aβ peptides and modeling of alzheimer's disease

Neurobiology of Aging

Volumn 13, Issue 5, 1992, Pages 623-625

  Price, Donald L ^a   Borchelt, David R ^a   Walker, Lary C ^a   Sisodia, Sangram S ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; SYNTHETIC PEPTIDE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BRAIN DEGENERATION; HUMAN; HUMAN TISSUE; NEUROSCIENCE; NEUROTOXICITY; NONHUMAN; RAT; SHORT SURVEY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMAL; DISEASE MODELS, ANIMAL; HUMAN; PEPTIDE FRAGMENTS;

EID: 0026739087     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/0197-4580(92)90069-A     Document Type: Article

References (40)

1. Methodological variables in the assessment of beta amyloid neurotoxicity
2. Implants containing β-amyloid protein are not neurotoxic to young and old rat brain
3. Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits
4. β-amyloid neurotoxicity: A discussion of in vitro findings
5. Alz 50 as a reagent to assess animal models of Alzheimer's disease
6. The acute neurotoxicity and effects upon cholinergic axons of intracerebrally injected βamyloid in the rat brain
7. Effects of injected Alzheimer βamyloid cores in rat brain
8. The familial Alzheimer's disease mutation does not produce gross alterations in APP synthesis or processing
9. Lack of Alzheimer pathology after β-amyloid protein injections in rat brain
10. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
11. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
12. Spontaneous neurodegeneration in transgenic mice with mutant prion protein
13. Amyloid-β peptide, substance P, and bombesin bind to the serpin-enzyme complex receptor
14. An in vivo model for the neurodegenerative effects of β-amyloid and protection by substance P
15. In vivo neurotoxicity of beta amyloid [β(1–40)] and the β(25–35) fragment
16. A68: A major subunit of paired helical filaments and derivatized forms of normal tau
17. Effect of beta amyloid peptides on neurons in hippocampal slide cultures
18. The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome
19. Amyloid precursor protein in aged nonhuman primates
20. Amyloid plaque core protein in Alzheimer disease and Down syndrome
21. β-amyloid peptide in vitro toxicity: lot-to-lot variability
22. Aggregation-related toxicity of synthetic β-amyloid protein in hippocampal cultures
23. In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity
24. Synthetic amyloid β-protein fails to produce specific neurotoxicity in monkey cerebral cortex
25. Formation of β-amyloid protein deposits in brains of transgenic mice
26. Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease
27. Intracerebral β-amyloid(25–35) produces tissue damage. Is it neurotoxic?
28. Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease
29. Sisodia, S. S.; Price, D. L. Alzheimer's disease-type brain abnormalities in animal models. Curr. Biol. (in press).
30. Failure of betaamyloid protein fragment 25–35 to cause hippocampal damage in the rat
31. Senile plaques in cortex of aged normal monkeys
32. Solvent effects on beta protein toxicity in vivo
33. The neural basis of memory decline in aged monkeys
34. Reexamination of the pathogenesis of the senile plaque
35. Alzheimer-related neuronal protein A68: Specificity and distribution
36. Commentary and perspective on studies of beta amyloid neurotoxicity
37. Nerve growth factor potentiates the neurotoxicity of a amyloid
38. Neurotrophic and neurotoxic effects of amyloid β protein: Reversal by tachykinin neuropeptides