Accumulation of p53 Protein Correlates with a Poor Prognosis in Human Lung Cancer

Cancer Research

Volumn 52, Issue 17, 1992, Pages 4828-4831

  Quinlan, Dennis C ^a,b,c   Davidson, Ann G ^b,c   Summers, Carol L ^b,c   Warden, Herbert E ^b,c  

^a Department of Biology ^*  (United States)

^b Surgery   (United States)

^c WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; PROTEIN P53;

ADENOCARCINOMA; ARTICLE; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOPEROXIDASE STAINING; LUNG CANCER; LYMPH NODE METASTASIS; PRIORITY JOURNAL; PROGNOSIS; SQUAMOUS CELL CARCINOMA; SURVIVAL TIME;

ADENOCARCINOMA; CARCINOMA, NON-SMALL-CELL LUNG; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; PROGNOSIS; PROTEIN P53; RETROSPECTIVE STUDIES;

EID: 0026737950     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Parada, L. F., Land, H., Weinberg, R. A., Wolf, D., and Rotter, V. Cooperation between gene encoding p53 tumor antigen and ras in cellular transformation. Nature (Lond.), 312: 649-651, 1984.
2. Mercer, W. E., Shields, M. T., Amin, M., Sauve, G. J., Appella, E., Romano, J. W., and Ullrich, S. J. Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53. Proc. Natl. Acad. Sci. USA, 87:6166-6170, 1990.
3. Baker, S. J., Markowitz, S., Fearon, E. R., Willson, J. K., and Vogelstein, B. Suppression of human colorectal carcinoma cell growth by wild-type pS3. Science (Washington DC), 249:912-915, 1990.
4. Nigro, J. M., Baker, S. J., Presinger, A. C., Jessup, J. M., Hostetter, R., Cleary, K., Bigner, S. H., Davidson, N., Baylin, S., Devilee, P., Glover, T., Collins, F. S., Weston, Al, Modali, R., Harris, C. C., and Vogelstein, B. Mutations in the pSS gene occur in diverse human tumor types. Nature (Lond.), 342: 705-708, 1989.
5. Hollstein, M., Sidransky, D., Vogelstein, B., and Harris, C. p53 mutations in human cancers. Science (Washington DC), 253:49-53, 1991.
6. Li, F. P., Fraumeni, J. F., Jr., Mulvihill, J. J., Blattner, W. A., Dreyfus, M. G., Tucker, M. A., and Miller, R. W. A cancer family syndrome in 24 kindreds. Cancer Res., 48: 5358-5362, 1988.
7. Findlay, C. A., Hinds, P. W., and Levine, A. J. The p53 proto-oncogene can act as a suppressor of transformation. Cell, 57: 1083-1093, 1989.
8. Unger, T., Nau, M. M., Segal, S., and Minna, J. D. p53 a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer. EMBO J., 11: 1383-1390, 1992.
9. El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., and Vogelstein, B. Definition of a consensus binding site for p53. Nature Genet., 1:45-49, 1992.
10. Wolf, D., Harris, N., and Rotter, V. Reconstitution of p53 expression in nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene. Cell, 38: 119-126, 1984.
11. Takahashi, T., Nau, M. M., Chiba, I., Birrer, M. J., Rosenberg, R. K., Vinocour, M., Levitt, M., Pass, H., Gazdar, A. F., and Minna, J. D. p53: a frequent target for genetic abnormalities in lung cancer. Science (Washington DC), 246: 491-494, 1989.
12. Iggo, R., Gatter, K., Bartek, J., Lane, D., and Harris, A. L. Increased expression of mutant forms of p53 oncogene in primary lung cancer. Lancet, 335: 675-679, 1990.
13. Viallet, J., and Minna, J. D. Dominant oncogenes and tumor suppressor genes in the pathogenesis of lung cancer. Am. J. Cancer Res., 83:101-106, 1992.
14. Chiba, I., Takahashi, T., Nau, M. M., Damico, D., Cunel, D. T., Mitsu-domi, T., Buchhagen, D. L., Carbone, D., Pianudosi, S., Koga, H., Reiss-man, P. T., Slamon, D. J., Holmes, E. C., and Minna, J. D. Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Oncogene, 5: 1603-1610, 1990.
15. Hiyoshi, H., Matsuno, Y., Kato, H., Shimosato, V., and Hirohashi, S. Cli-nocopathological signiflcance of nuclear accumulation of tumor suppressor gene p53 product in primary lung cancer. Jpn. J. Cancer Res., 83:101-106, 1992.
16. Suzuki, H., Takahashi, T., Kuroishi, T., Suyama, M., Anyoshi, Y., and Takahashi, T. p53 mutations in non-small cell lung cancers in Japan: association between mutations and smoking. Cancer Res., 52: 734-736, 1992.
17. Vahakangas, K. H., Samet, J. M., Metcalf, R. A., Welsh, J. A., Bennett, W. P., Lane, D. P., and Harris, C. C. Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners. Lancet, 339: 576-580, 1992.
18. Hsu, S-M., Raine, L., and Fanger, H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques. J. Histochem. Cytochem., 29: 577-580, 1981.
19. Matlashewski, G., Banks, L., Pim, D., and Crawford, L. Analysis of human p53 proteins and mRNA levels in normal and transformed cells. Eur. J. Biochem., 754: 665-672, 1986.
20. Rogel, A., Popliker, M., Webb, G. L., and Oren, M. p53 cellular tumor antigen: analysis of mRNA levels in normal cell adult tissues, embryos, and tumors. Mol. Cell. BioL, 5: 2851-2855, 1985.
21. Ostrowski, J. L., Swan, A., Henry, L., Wright, C., Hennessy, C., Lennard, T. J. W., Angus, B., and Home, C. H. W. p53 expression in human breast cancer related to survival and prognostic factors: an immunohistochemical study. J. Pathol., 164: 75-81, 1991.
22. Martin, M. M., Filipe, M. I., Morris, R. W., Lane, D. P., and Silvestre, F. p53 expression and prognosis in gastric carcinoma. Int. J. Cancer, 50:859-862, 1992.
23. Scott, N., Sagar, P., Stewart, J., Blair, G. E., Dixon, M. F., and Quirke, P. p53 in colorectal cancer clinicopathological correlation and prognostic significance. Br. J. Cancer, 63:317-319, 1991.
24. Naylor, S., Johnson, B., Minna, J., and Sakaguchi, A. Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer. Nature (Lond.), 329: 451-454, 1987.
25. Kok, K., Osinga, J., Carritt, B., Davis, M. B., van der Hout, A. H., van der Veen, A. Y., Undsvater, R. M., dcLeu, L. F. M. H., Berendsen, H. H., Postmus, P. E., Poppema, S., and Buys, C. H. C. M. Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer. Nature (Lond.), 330: 578-581, 1987.