The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice

Cancer and Metastasis Review

Volumn 11, Issue 2, 1992, Pages 179-195

  Potten, Christopher S ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

apoptosis; apoptosis quantification; apoptosis spatial distribution; colon; cytotoxic drugs; cytotoxic induced apoptosis; radiation; small intestine; spontaneous apoptosis; tissue homeostasis

Indexed keywords

BLEOMYCIN; CHLORMETHINE; CYCLOPHOSPHAMIDE; CYTOTOXIC AGENT; DACTINOMYCIN; DNA; DOXORUBICIN; FLUOROURACIL; HYDROXYUREA; METHOTREXATE; NITROSOUREA; SULFONIC ACID DERIVATIVE; THIOTEPA; THYMIDINE DERIVATIVE; VINCRISTINE;

APOPTOSIS; CELL GROWTH; CELL STRUCTURE; CRYPT CELL; CYTOTOXICITY; DNA DAMAGE; GASTROINTESTINAL TRACT; GROWTH REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; STEM CELL;

ANIMAL; APOPTOSIS; DNA DAMAGE; GASTRIC MUCOSA; INTESTINAL MUCOSA; MICE; MUTAGENS; SUPPORT, NON-U.S. GOV'T;

EID: 0026731996     PISSN: 01677659     EISSN: 15737233     Source Type: Journal    
DOI: 10.1007/BF00048063     Document Type: Article

References (52)

1. The stem-cell zone of the small intestinal epithelium. 1. Evidence from Paneth cells in the adult mouse
2. Identification of stem cells in the small intestine of the mouse
3. Stem cells in murine intestine
4. Cytotoxic effects in gastro-intestinal epithelium (as exemplified by small intestine)
5. The control of cell proliferation in the gastro-intestinal tract
6. Epithelial stem cells in vivo
7. Stem cells; attributes, cycles, spirals, uncertainties and pitfalls; lessons for and from the crypt
8. New estimates of the number of clonogenic cells in crypts of murine small intestine
9. The doubling time of regenerating clonogenic cells in the crypts of the small intestine
10. The spatial organisation of the hierarchical proliferative cells of the small intestine into clusters of ‘synchronised’ cells
11. The in vivo measurement of proliferation in normal human colorectal mucosa using bromodeoxyuridine
12. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics
13. An electron-microscope study of the mode of cell death induced by cancer chemotherapeutic agents in populations of proliferating normal and neoplastic cells
14. Cell death: a new classification separating apoptosis from necrosis
15. Apoptosis: cell death in tissue regulation
16. Cell death: the significance of apoptosis
17. Programmed cell death: new thoughts and relevance to aging
18. Social controls on cell survival and cell death
19. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
20. BCL-2 protein is topographically restricted in tissues characterized by apoptotic cell death
21. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
22. Extreme sensitivity of some intestinal crypt cells to χ and γ irradiation
23. Circadian rhythms of presumptive stem cells in three different epithelia of the mouse
24. Response of intestinal cells of differing topographical and hierarchial status to ten cytotoxic drugs and five sources of radiation
25. Stem cells in gastrointestinal mucosa
26. Differential radiation response amongst proliferating epithelial cells
27. The segregation of DNA in epithelial stem cells
28. Cell death (apoptosis) in the mouse small intestine after low doses: effects of dose-rate 14.7 Me V neutrons and 600 Me V (maximum enery) neutrons
29. Cell death (apoptosis) in hair follicles and consequent changes in the width of hairs after irradiation of growing hairs
30. Target cells for the cytotoxic effects of carcinogens in the murine small bowel
31. Mutation selection and the natural history of cancer
32. Further studies on the response of intestinal crypt cells of different hierarchical status to cytotoxic drugs
33. Morphological evaluation of the effects of Shiga toxin and E. coli Shiga-like toxin on the rabbit intestine
34. Cell cycles in cell hierarchies
35. A comprehensive study of the radiobiological response of the murine (BDF1) small intestine
36. Recruitment of cells in the small intestines into rapid cell cycle by small doses of external or internal radiation
37. The recruitability and cell cycle state of intestinal stem cell
38. The temporal and spatial changes in cell proliferation within the irradiated crypts of the murine small intestine
39. Clonogenic, stem and carcinogen-target cells in small intestine
40. Epidermal Cell Proliferation I. Changes with time in the proportion of isolated, paired and clustered labelled cells in sheets of murine epidermis