Conversion of human interleukin-4 into a high affinity antagonist by a single amino acid replacement

EMBO Journal

Volumn 11, Issue 9, 1992, Pages 3237-3244

  Kruse, N ^a   Tony, H P ^b   Sebald, W ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Drug design; Partial agonists; Receptor signalling

Indexed keywords

ASPARAGINE; ASPARTIC ACID; GLYCINE; HISTIDINE; INTERLEUKIN 4; INTERLEUKIN DERIVATIVE; INTERLEUKIN RECEPTOR; LIGAND; LYSINE; PHENYLALANINE; RECOMBINANT PROTEIN; TYROSINE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; Y 124D;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; DRUG DESIGN; HUMAN; LYMPHOCYTE DIFFERENTIATION; PRIORITY JOURNAL; RECEPTOR BINDING;

ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; B-LYMPHOCYTES; BINDING, COMPETITIVE; CELL DIFFERENTIATION; CELLS, CULTURED; ESCHERICHIA COLI; HUMAN; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, FC; RECEPTORS, IGE; RECEPTORS, INTERLEUKIN-4; RECEPTORS, MITOGEN; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES; VARIATION (GENETICS);

EID: 0026731478     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1992.tb05401.x     Document Type: Article

References (52)

1. Abdel-Meguid,S.S., Shieh,H.-S., Smith,W.W., Dayringer,H.E., Violand,B.N. and Bentle,L.A. (1987) Proc. Natl. Acad. Sci. USA, 84, 6434-6437.
2. Bazan,J.F. (1990a) Proc. Natl. Acad. Sci. USA, 87, 6934-6938.
3. Bazan,J.F. (1990b) Immunology Today, 11, 350-354.
4. Black,J. (1989) Science, 245, 486-493.
5. Brandhuber,B.J., Boone,T., Kenney,W.C. and McKay,D.B. (1987) Science, 238, 1707-1709.
6. Cabrillat,J., Galizzi,J.-P., Djossou,O., Arai,N., Yokota,T., Arai,K. and Banchereau,J. (1987) Biochem. Biophys. Res. Commun., 149, 995-1001.
7. Collins,L. et al. (1988) Proc. Natl. Acad. Sci. USA, 85, 7709-7713.
8. Cook,W.J., Ealick,S.E., Reichert,P., Hammond,G.S., Le,H.V., Nagabhushan,T.L., Trotta,P.P. and Bugg,C.E. (1991) J. Mol. Biol., 218, 675-678.
9. Cosman,D., Lyman,S.D., Idzerda,R.L., Beckman,M.P., Park,L.S., Goodwin,R.G. and March,C.J. (1990) Trends Biochem. Sci., 15, 265-270.
10. Cunningham,B.C. and Wells,J.A. (1991) Proc. Natl. Acad. Sci. USA, 88, 3407-3411.
11. Cunningham,B.C., Ultsch,M., De Vos,A.M., Mulkerrin,M.G., Clauser,K.R. and Wells,J.A. (1991) Science, 254, 821-825.
12. DeFrance,T. et al. (1987) J. Exp. Med., 165, 1459-1467.
13. De Vos,A.M., Ultsch,M. and Kossiakoff,A.A. (1992) Science, 255, 306-312.
14. Diederichs,K., Boone,T. and Karplus,P.A. (1991) Science, 254, 1779-1782.
15. Eisenberg,S.P., Evans,R.J., Arend,W.P., Verderber,E., Brewer,M.T., Hannum,C.H. and Thompson,R.C. (1990) Nature, 343, 341-346.
16. Finkelman,F.D. et al. (1990) Annu. Rev. Immunol., 8, 303-333.
17. Galizzi,J.-P., Zuber,C.E., Harada,N., Gorman,D.M., Djossou,O., Kastelein,R., Banchereau,J., Howard,M. and Miyajima,A. (1990) Int. Immunol., 2, 669-675.
18. Garrone,P., Djossou,O., Galizzi,J.-P. and Banchereau,J. (1991) Eur. J. Immunol., 21, 1365-1369.
19. Gehrke,L., Jobling,S.A., Paik,L.S.K., McDonald,B., Rosenwasser,L.J. and Auron,P.E. (1990) J. Biol. Chem., 265, 5922-5925.
20. Grant,A.J., Roessler,E., Ju,G., Tsudo,M., Sugamura,K. and Waldmann,T.A. (1992) Proc. Natl. Acad. Sci. USA, 89, 2165-2169.
21. Hannum,C.H., Wilcox,C.J., Arend,W.P., Joslin,F.G., Dripps,D.J., Heimdal,P.L., Armes,L.G., Sommer,A., Eisenberg,S.P. and Thompson,R.C. (1990) Nature, 343, 336-340.
22. Harada,N., Castle,B.E., Gorman,D.M., Itoh,N., Schreurs,J., Barrett,R.L., Howard,M. and Miyajima,A. (1990) Proc. Natl. Acad. Sci. USA, 87, 857-861.
23. Idzerda,R.L. et al. (1990) J. Exp. Med., 171, 861-873.
24. Ju,G. et al. (1991) Proc. Natl. Acad. Sci. USA, 88, 2658-2662.
25. Kikutani,H. et al. (1986) Cell. 47, 657-665.
26. Kruse,N., Lehrnbecher,T. and Sebald,W. (1991) FEBS Lett., 286, 58-60.
27. Kühn,R., Rajewsky,K. and Müller,W. (1991) Science, 254, 707-710.
28. Labriola-Tompkins,E. et al. (1991) Proc. Natl. Acad. Sci. USA, 88, 11182-11186.
29. Liang,S.-M., Lee,N., Zoon,K.C., Manischewitz,J.F., Chollet,A., Liang, C.-M. and Quinnan,G.V. (1988) J. Biol. Chem., 263, 4768-4772.
30. Maliszewski,C.R., Sato,T.A., Vanden Bos,T., Waugh,S., Dower,S.K., Slack,J., Beckmann,M.P. and Grabstein,K.H. (1990) J. Immunol., 144, 3028-3033.
31. Mosley,B. et al. (1989) Cell, 59, 335-348.
32. Munson,P.J. (1983) Methods EnzymoL, 92, 543-576.
33. Park,L.S., Friend,D., Sassenfeld,H.M. and Urdal,D.L. (1987) J. Exp. Med., 166, 476-488.
34. Paul,W.E. and Ohara,J. (1987) Annu. Rev. Immunol., 5, 429-459.
35. Paul,W.E. (1991) Blood, 77, 1859-1870.
36. Redfield,C., Smith,L.J., Boyd,J., Lawrence,G.M.P., Edwards,R.G., Smith,R.A.G. and Dobson,C.M. (1991) Biochemistry, 30, 11029-11035.
37. Ringheim,G.E., Freimark,B.D. and Robb,R.J. (1991) Lymphokine Cytokine Res., 10, 219-224.
38. Ruffolo,R.R.Jr (1982) J. Auton. Pharmac., 2, 277-295.
39. Sanderson,C.J., Campbell,H.D. and Young,I.G. (1988) Immunol. Rev., 102, 29-50.
40. Shanafelt,A.B., Miyajima,A., Kitamura,T. and Kastelein,R.A. (1991) EMBO J., 10, 4105-4112.
41. Solari,R. et al. (1989) Biochem. J., 262, 897-908.
42. Schlessinger,J. (1988) Trends Biochem. Sci., 13, 443-447.
43. Tepper,R.I., Levinson,D.A., Stanger,B.Z., Campos-Torres,J., Abbas,A.K. and Leder,P. (1990) Cell, 62, 457-467.
44. Ullrich,A. and Schlessinger,J. (1990) Cell, 61, 203-212.
45. Urban,J.F.Jr, Katona,J.M., Paul,W.E. and Finkelman,F.D. (1991) Proc. Natl. Acad. Sci. USA, 88, 5513-5517.
46. Weigel,U., Meyer,M. and Sebald,W. (1989) Eur. J. Biochem., 180, 295-300.
47. Williams,L.T. (1989) Science, 243, 1564-1570.
48. Yamayoshi,M., Ohue,M., Kawashima,H., Kotani,H., Iida,M., Kawata,S. and Yamada,M. (1990) Lymphokine Res., 9, 405-413.
49. Yokota,T., Otsuka,T., Mosmann,T., Banchereau,J., DeFrance,T., Blanchard,D., De Vries,J.E., Lee,F. and Arai,K.-I. (1986) Proc. Natl. Acad. Sci. USA, 83, 5894-5898.
50. Zurawski,S.M. and Zurawski,G. (1989) EMBO J., 8, 2583-2590.
51. Zurawski,S.M., Imler,J.-L. and Zurawski,G. (1990) EMBO J., 9, 3899-3905.
52. Zurawski,G. (1991) Trends Biotechnol., 9, 250-257.