Suppression by dynorphin A-(1-13) of the expression of opiate withdrawal and tolerance in mice

European Journal of Pharmacology

Volumn 221, Issue 2-3, 1992, Pages 223-226

  Takemori, A E ^a   Loh, Horace H ^a   Lee, Nancy M ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Dynorphin A (1 13); Morphine; Opiate tolerance; Opiate withdrawal

Indexed keywords

DYNORPHIN[1-13]; MORPHINE; NALOXONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; INTRAVENOUS DRUG ADMINISTRATION; JUMPING; MALE; MORPHINE TOLERANCE; MOUSE; NONHUMAN; OPIATE ADDICTION; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; WITHDRAWAL SYNDROME;

ANIMAL; DRUG TOLERANCE; DYNORPHINS; MALE; MICE; MORPHINE; NALOXONE; OPIOID-RELATED DISORDERS; PEPTIDE FRAGMENTS; SUBSTANCE WITHDRAWAL SYNDROME; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026730434     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(92)90705-9     Document Type: Article

References (15)

1. Dynorphin A-(1–13): effects in nontolerant and morphine-dependent rhesus monkeys
2. Failure of an opiate to protect mice against naloxone-precipitated withdrawal
3. Dynorphin A-(1–13) attenuates withdrawal in morphine-dependent rats: effect of route of administration
4. The type of analgesic-receptor interaction involved in certain analgesic assays
5. Significance of withdrawal jumping response in predicting physical dependence in mice
6. 2-dynorphin A-(1–11) (kappa opioid agonists) in morphine (mu opioid agonist)-dependent rats
7. Relationship of brain morphine levels to analgesic activity in acutely treated mice and rats and in pellet-implanted mice
8. Modulation of acute morphine tolerance by corticotropin-releasing factor and dynorphin A in the mouse spinal cord
9. Norbinaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays
10. Possible regulatory role of dynorphin A on morphine- and β-endorphin-induced analgesia
11. Simultaneous quantitative assessment of morphine tolerance and physical dependence
12. Comparison of the effectiveness of different opioid peptides in suppressing heroin withdrawal
13. Inhibition by naloxone of tolerance and dependence in mice-treated acutely and chronically with morphine