Multistage carcinogenesis in mouse skin

Pharmacology and Therapeutics

Volumn 54, Issue 1, 1992, Pages 63-128

  DiGiovanni, John ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKANE; CARCINOGEN; FATTY ACID; HALOGENATED HYDROCARBON; PHENOL DERIVATIVE; PHORBOL ESTER; POLYCYCLIC AROMATIC HYDROCARBON; SURFACTANT; TOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CARCINOGENESIS; CONTROLLED STUDY; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; REVIEW; SKIN; TOBACCO; TUMOR GROWTH;

ANIMAL; CARCINOGENS; COCARCINOGENESIS; MICE; SKIN NEOPLASMS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026729695     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/0163-7258(92)90051-Z     Document Type: Review

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117. Tumor promotion and the induction of epidermal ornithine decarboxylase activity in mechanically stimulated mouse skin
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119. Expression of the c-fos gene and of a fos-related gene is stimulated by platelet-derived growth factor
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122. Decrease of epidermal histidase activity by tumor-promoting phorbol esters
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133. Effects of phorbol ester tumor promoters and hyperplasiogenic agents on cytoplasmic glucocorticoid receptors in epidermis
134. Glucocorticoid receptor levels in mouse skin after repetitive applications of 12-O-tetradecanoylphorbol-13-acetate and mezerin
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178. UV-induced DNA damage and its repair in human skin in vivo studied by immunohistochemical methods
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183. UVR induction of TGFα: a possible autocrine mechanism for the epidermal melanocytic response and for promotion of epidermal carcinogenesis
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185. Tumor promoter phorbol-12-myristate-13-acetate induces chromosomal damage via indirect action
186. Experimental UVL carcinogenesis
187. Defect in DNA synthesis in skin of patients with Xeroderma Pigmentosum demonstrated in vivo
188. Tumor progression in SENCAR mouse skin as a function of initiator dose and promoter dose, duration, and type
189. Enhancement of mezerein-promoted papilloma formation by treatment with 12-O-tetradecanoylphorbol-13-acetate or mezerein prior to initiation
190. Further characterization of skin tumor promotion and progression by mezerin in SENCAR mice
191. Clonal analysis of human colorectal tumors
192. Binding characteristics of Ah receptors from rats and mice before and after separation from hepatic cytosols. 7-Hydroxyellipticine as a competitive antagonist of cytochrome P-450 induction
193. TGFa stimulates growth of skin papillomas by autocrine and paracrine mechanisms but does not cause neoplastic progression
194. Suppression of tumor promoter-induced chemiluminescence in mouse epidermal cells by several inhibitors of arachidonic acid metabolism
195. Prostaglandin enhancement of skin tumor initiation and promotion
196. Prostaglandin modulation of phorbol ester skin tumor promotion
197. Indomethacin enhancement of TPA tumor promotion in mice
198. Inhibition of mouse skin tumor promotion by several inhibitors of arachidonic acid metabolism
199. Separation of epidermal cells by density centrifugation: a new technique for studies on normal and pathological differentiation
200. Retinoyl-phorbol-acetate is a complete skin tumor promoter in SENCAR mice
201. Effects of antipromoters and mouse strain on promoter-induced oxidants in murine epidermal cells
202. Events associated with mouse skin tumor promotion with respect to arachidonic acid metabolism: A comparison between SENCAR and NMRI mice
203. Phorbol ester induction of 8-lipoxygenase in inbred Sencar (SSIN) but not C57BL/6J mice, correlated with hyperplasia, edema and oxidant generation but not ornithine decarboxylase induction
204. The arachidonic acid cascade and multistage carcinogenesis in mouse skin
205. Effects of antihistamines on phorbol ester tumor promotion and vascular permeability changes
206. Suppressor T lymphocytes control the development of primary skin cancers in ultraviolet-irradiated mice
207. Interactions between adenovirus, a tumor promoter, and chemical carcinogens in transformation of rat embryo cell cultures
208. Detection of high incidence of k-ras oncogenes during human colon tumorigenesis
209. 1
210. The role of the (6-4) photoproduct in ultraviolet light-induced transition mutations in E. coli.
211. Biology of disease: free radicals and tissue injury
212. Diurnal variation in the susceptibility of mouse epidermis to carcinogen and its relationship to DNA synthesis
213. Phosphorylation at threonine-654 is not required for negative regulation of the epidermal growth factor receptor by non-phorbol tumor promoters
214. The initiating and promoting elements in tumor production An analysis of the effects of tar benzpyrene and methylcholanthrene on rabbit skin
215. New classes of tumor promoters: teleocidin, lyngbyatoxin A, and aplysiatoxin
216. Indole alkaloids: dihydroteleocidin b, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters
217. Teleocidin from Streptomyces is a potent promoter of mouse skin carcinogenesis
218. The third class of new tumor promoters, polyacetates (debromoaplysiatoxin and aplysiatoxin), can differentiate biological actions relevant to tumor promoters
219. Palytoxin is a non-12-O-tetradecanoylphorbol-13 acetate type tumor promoter in two-stage mouse skin carcinogenesis
220. Induction of orinthine decarboxylase activity in mouse skin by a possible tumor promoter, okadaic acid
221. Diversity in the chemical nature and mechanism of response to tumor promoters
222. 2 in mouse epidermis in vivo
223. Early prostaglandin E synthesis is an obligatory event in the induction of cell proliferation in mouse epidermis in vivo by the phorbol ester TPA
224. Growth stimulation and tumor promotion in skin
225. Skin tumor promotion by phorbol esters is a two-stage process
226. Tumor promotion by phorbol esters in skin: evidence for a memory effect
227. Partial inversion of the initiation-promotion sequence of multistage tumorigenesis in the skin of NMRI mice
228. Stimulatory role of transforming growth factors in multistage skin carcinogenesis: possible explanation for the tumor-inducing effect of wounding in initiated NMRI mouse skin
229. Tumor induction in initiated mouse skin by phorbol esters and methyl methane sulfonate: correlation between chromosomal damage and conversion (stage I of tumor promotion) in vivo
230. Phenotypic and chromosomal alterations in cell cultures are indicators of tumor-promoting activity
231. Benzo[a]pyrene metabolism, activation, and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes
232. Enhancement of chemical carcinogenesis in mice by systemic effects of ultraviolet irradiation
233. Prevention of chemically induced two-stage skin carcinogenesis in mice by systematic effects of ultraviolet irradiation
234. The effect of cortisone on chemical carcinogenesis in the mouse skin
235. DNA repair following ultraviolet and N-ethyl-N-nitrosourea treatment of cells cultured from human fetal brain, intestine, kidney, liver and skin
236. Identification of a receptor for the morphogen retinoic acid
237. Relationship between DNA adduct formation and unscheduled DNA synthesis (UDS) in cultured mouse epidermal keratinocytes
238. Analysis of point mutations in murine c-Ha-ras of skin tumors initiated with dibenz[a,j]anthracene and derivatives
239. The morphology of the denuded epidermal basal cell layer of the hairless mouse after different preparation methods, a scanning and transmission electron microscopical study
240. The influence of fixation on the morphology of mouse epidermis. A light and electron microscopical study with special reference to “dark cells” and epidermal carcinogenesis
241. Morphometric evaluation of the changes affecting the basal keratinocytes in hairless mouse epidermis during early 2-stage chemical carcinogenesis and after two different fixation methods
242. The influence of different fixatives and a tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on the induction of so-called dark cells in mouse epidermis A light microscopical study
243. The influence of fixation on the relative amount of cytoplasmic ribosomes in mouse epidermal basal keratinocytes. A morphometric study of so-called ‘dark cells’ and their putative role in epidermal carcinogenesis
244. Hypomethylation of DNA from benign and malignant human colon neoplasms
245. Diaplacental carcinogenesis: initiation with the carcinogens dimethylbenzanthracene (DMBA) and urethane during fetal life and postnatal promotion with the phorbol ester TPA in a modified 2-stage Berenblum/Mottram experiment
246. Diaplacental carcinogenesis: tumor localization and tumor incidence in NMRI mice after diaplacental initiation with DMBA and urethane and postnatal promotion with the phorbol ester TPA in a modified 2-stage Berenblum/Mottram experiment
247. Two-stage skin carcinogenesis by systemic initiation of pregnant mice with 7,12-dimethylbenz[a]anthracene during gestation days 6–20 and postnatal promotion of the F1-generation with the phorbol ester 12-tetradecanoylphorbol-13-acetate
248. 2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain
249. Stimulation of 3T3 cells induces transcription of the c-fos protooncogene
250. Maliganant conversion of murine squamous papilloma cell lines by transfection with the fos oncogene
251. Two oncogenes, v-fos and v-ras, cooperate to convert normal keratinocytes to squamous cell carcinoma
252. Effect of tumor-promoting phorbol esters on the normal and the isoproterenol-elevated level of adenosine 3′,5′ monophosphate in mouse epidermis
253. A phorbol ester and phospholipid-activated, calcium-unresponsive protein kinase in mouse epidermis: characterization and separation from protein kinase C
254. Mutational activation of oncogenes in animal model systems of carcinogenesis
255. Levels of cytochrome P-450-mediated aryl hydrocarbon hydroxylase (AHH) are higher in differentiated than in germinative cutaneous keratinocytes
256. Selective activation of some dihydrodiols of several polycylic aromatic hydrocarbons to mutagenic products by prostaglandin synthetase
257. Studies on co-carcinogenesis SH-reactors and other substances tested for co-carcinogenic action in mouse skin
258. ζ-related protein kinase C in nucleii of nerve cells
259. The metabolism of indole alkaloid tumor promoter, (−)-indolactam V, which has the fundamental structure of teleocidins, by rat liver microsomes
260. Thapsigargin a histamine secretagogue is a non-12-O-tetradecanoylphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis
261. Polycyclic aromatic hydrocarbons: metabolism, activation and tumour initiation
262. Glyceraldehydephosphate dehydrogenase and glucose-6-phosphate dehydrogenase activities in psoriasis and neurodermatitis and the effect of dithranol
263. DNA repair responses in human skin cells
264. Differential down-regulation of epidermal protein kinase C by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol: association with epidermal hyperplasia and tumor promotion
265. The association of DNA strand breaks and terminal differentiation in mouse epidermal cells exposed to tumor promoters
266. Mouse keratinocytes derived from initiated skin or papillomas are resistant to DNA strand breakage by benzoyl peroxide: a possible mechanism for tumor promotion mediated by benzoyl peroxide
267. Nutrition as a modifier of chemical carcinogenesis
268. Effects of the tumor promoter okadaic acid on intracellular protein phosphorylation and metabolism
269. A study of tobacco carcinogenesis. XIII. Tumor-promoting subfractions of the weakly acidic fraction
270. Cocarcinogenic principles from the seed oil of Croton tiglium and from other Euphorbiaceae
271. Isolation and characterization of the cocarcinogenic principles from croton oil
272. Structure-activity relationships in diterpene esters irritant and cocarcinogenic to mouse skin
273. Chemical carcinogenesis
274. Studies on the mechanism of skin tumor promotion
275. Guanine-specific DNA repair after treatment of mouse skin cells with N-methyl-N′-nitro-N-nitrosoguanidine
276. Two-stage tumor promotion in mouse skin: an alternative interpretation
277. The effect of croton oil pretreatment on skin tumor initiation in mice
278. Enhancement of skin tumorigenesis by a single application of croton iol before or soon after initiation by urethan
279. Purine-specific repair of β-propiolactone-induced DNA damage in mouse skin
280. Croton oil enhancement of skin tumor initiation by N-methyl-N′-nitro-N-nitrosoguanidine: Possible role of DNA replication
281. Calcium regulation of growth and differentiation of mouse epidermal cells in culture
282. Comparison of two-stage epidermal carcinogenesis initiated by 7,12-dimethylbenz[a]anthracene or N-methyl-N′-nitro-N-nitrosoguanidine
283. Retinoic acid promotion of papillomas formation in mouse skin
284. Malignant conversion of mouse skin tumors is increased by tumor initiators and unaffected by tumor promoters
285. Byrostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin
286. Okadaic acid-induced hyperphosphorylation of the epidermal growth factor receptor
287. Effects of a protein phosphatase inhibitor okadaic on membrane currents of isolated guinea pig cardiac myocytes
288. Applicability of bacterial models of DNA repair and recovery to UV-irradiated mammalian cells
289. Inhibition of mouse skin tumor promotion and of promoter-induced epidermal polyamine biosynthesis by methyl-glyoxal bis (butylamidinohydrazone)
290. PDGF-induced activation of phospholipase C is not required for induction of DNA synthesis
291. sn-1,2-Didecanoylglycerol effectively induces epidermal ornithine decarboxylase but only weak hyperplasia in mouse skin
292. Partial characterization of epidermal protein kinase C in mice sensitive or resistant to phorbol ester
293. Mechanism of H-ras oncogene activation in mouse squamous carcinoma induced by an alkylating agent
294. Relationship between amount and type of dietary fat in promotion of mammary carcinogenesis induced by 7,12,-dimethylbenz[a]anthracene
295. UV-induced unscheduled DNA synthesis in cultured human epidermal and dermal cells
296. Inhibition of tumorigenesis in mouse skin by leupeptin, a protease inhibitor from actinomycetes
297. 2+-activated and phospholipid-dependent protein kinase
298. Biocmedical characterization of rat brain protein kinase C isozymes
299. Role of ultraviolet radiation in the induction of melanocytic tumors in hairless mice following 7,12-dimethylbenz[a]anthracene application and ultraviolet irradiation'
300. Chemical changes induced in DNA by ionizing radiation
301. Essential fatty acids and immune response
302. Purification and characterization of cytochrome P-450 induced by benz[a]anthracene in mouse skin microsomes
303. Differential mechanism for the inhibition of epidermal growth factor binding to its receptor on mouse keratinocytes by anthrones and phorbol esters
304. Evidence for autocrine/paracrine growth stimulation by transforming growth6factor-α during the process of skin tumor promotion
305. Phorbol ester induces the transcriptional stimulatory activity of the SV40 enhancer
306. Effect of nocardia rubra cell-wall skeleton treatment on tumor formation in two-stage chemical carcinogenesis of mouse skin
307. The cytochrome P-450 I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals
308. In vivo studies on age dependency of DNA repair with age in mouse skin
309. DNA and RNA adducts formed in hamster embryo cell cultures exposed to benzo[a]pyrene
310. Ionizing radiation as an initiator: effects of proliferation and promotion time on tumor incidence in mice
311. Detection of distinct transforming genes in X-ray induced tumors
312. Purification and characterization of three types of protein kinase C from rabbit brain cytosol.
313. Role protein kinase C in diacylglycerol-mediated induction of ornithine decarboxylase and reduction of epidermal growth factor binding
314. Dietary effects of menhaden oil on the growth and membrane lipid composition of rat mammary tumors
315. Association of the Ah locus with specific changes in metyrapone and ethylisocyanide binding to mouse liver microsomes
316. Cis- and trans-acting genetic elements responsible for induction of specific genes by tumor promoters, serum factor, and stress
317. Inhibition of 12-O-tetradecanophorbol-13-acetate-induced tumor promotion and ornitine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition
318. 2+-dependent protein kinase in heart, and inhibition of their phosphorylation by palmitoylcarnitine
319. Free radicals in tumor promotion
320. Inhibition of phorbol ester stimulated chemiluminescence in human polymorphonuclear leukocytes by retinoic acid and 5,6-epoxyretinoic acid
321. Inhibition of tumor promotion by a biomimetic superoxide dismutase
322. The EGF/TGFα receptor in skin
323. The role of aryl hydrocarbon hydroxylase in 7,12-dimethylbenz[a]anthracene skin tumorigenesis: on the mechanism of 7,8-benzoflavone inhibition of tumorigenesis
324. Tumor promoter induces sister chromatid exchanges: relevance to mechanisms of carcinogenesis
325. Three-stage tumorigenesis in mouse skin: DNA synthesis as a prerequisite for the conversion stage induced by TPA prior to initiation
326. Oncogene activation and tumor progression
327. Morphological evaluation of tumor promoter effects on mammalian skin
328. Pathology of human and experimental skin tumors
329. Numerical variation of dark cells in normal and chemically induced hyperplastic epidermis with age of animal and efficiency of tumor promoter
330. Induction of dark keratinocytes by 12-O-tetradecanoylphorbol-13-acetate and mezerein as an indicator of tumor-promoting efficiency
331. Quantitative evaluation of dark keratinocytes induced by several promoting and hyperplasiogenic agents
332. Separation of cells from normal and abnormal epidermis
333. Hereditary cancer: oncogenes and antiocogenes
334. Dose-response wavelength dependence and time course of ultraviolet radiation-induced unscheduled DNA synthesis in mouse skin in vivo
335. Local- and systemic-mediated suppression of contact hypersensitivity in mice by several structurally unrelated classes of tumor promoters
336. Arachidonic acid metabolism in cultured mouse keratinocytes
337. Relationship between levels of aryl hydrocarbon hydroxylase activity and susceptibility to 3-methylcholanthrene and benzo[a]pyrene-induced cancers in inbred strains of mice
338. Relationship between aryl hydrocarbon hydroxylase inducibility and sensitivity to chemically induced subcutaneous sarcomas in various strains of mice
339. Genetic control of susceptibility to 3-methylcholanthrene-induced subcutaneous sarcomas
340. 2,3,7,8-Tetrachlorodibenzo-p-dioxin as co-carcinogen causing 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically ‘nonresponsive’ at Ah locus
341. Structure specificity of the antipsoriatic anthrones
342. On the biochemical mechanism of tumorigenesis in mouse skin. V. Studies of the metabolism of tumor promoting and non-promoting phorbol derivatives in vivo and in vitro
343. Tumor promoters induce a transient expression of tumor associated genes in both basal and differentiated cells of the mouse epidermis
344. TGF-β1 and skin carcinogenesis: antiproliferative effect in vitro and TGF-β 1 mRNA expression during epidermal hyperproliferation and multistage tumorigenesis
345. Alterations in epidermal polyamine levels and DNA synthesis following topical treatment with chrysarobin in SENCAR mice
346. Characterization of skin tumor promotion and progression by chrysarobin in SENCAR mice
347. Histologic alterations produced by chrysarobin (1,8-dihydroxy-3-methyl-9-anthrone) in SENCAR mouse skin: Relationship to skin tumor promoting activity
348. Mutational specificity of depurination
349. Effect of tumor promoting agents on mutation frequency in cultured V79 Chinese hamster cells
350. Oxidants induce phosphorylation of ribosomal protein S6
351. Translocation and enhancement of phosphotransferase activity of protein kinase C following exposure of mouse epidermal cells to oxidants
352. 1 transition of cultured cells
353. Concerted nonsyntenic allelic loss in human colorectal carcinoma
354. Carcinogenesis by alkylating agents
355. Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol
356. Mechanism of tumors promoter inhibition of cellular binding of epidermal growth factor
357. Genetic differences in benzo[a]pyrene-iniated tumorigenesis in mouse skin
358. The bay region theory of polycyclic aromatic hydrocarbon carcinogenesis
359. Purification and characterization of a calcium-unresponsive, phorbol exter/phospholipid-activated protein kinase from porcine spleen
360. Protective effects of ellagic acid and other plant phenols on benzo[a]pyrene-induced neoplasia in rats
361. Induction and persistence of pyrimidine dimers n the epidermal DNA of two strains of hairless mice
362. Effects of type of dietary fat on phorbol ester-elicited tumor promotion and other events in mouse skin
363. Histone phosphorylation in phorbol ester stimulated and β-adrenergically stimulated mouse epidermis in vivo and characterization of an epidermal protein phosphorylation system
364. DNA repair in cultured keratinocytes
365. Lack of a protective effect of menhaden oil on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate
366. The effect of various dietary fats on skin tumor initiation
367. Mutagenesis by apurinic/apyrimidinic sites
368. On the persistence of tumor initiation in two-stage carcinogenesis on mouse skin
369. Ultraviolet light induces epidermal ornithine decarboxylase activity
370. Enhancement of carcinogenesis by prostaglandins in male albino Swiss mice
371. Host-environmental interaction and carcinogenesis in man
372. Effects of phorbol ester tumor promoters on the binding processing, and biological activity of epidermal growth factor
373. Significant variation in mouse-skin aryl hydrocarbon hydroxylase inducibility as a function of the hair growth cycle
374. Role of tranforming growth factor-beta in the maturation of human epidermal keratinocytes
375. Purification and characterisation of bovine brain protein kinase C isotypes α, β, and γ
376. Epidermal growth control mechanisms, hyperplasia, and tumor promotion in the skin
377. The conversion stage of skin carcinogenesis
378. Diurnal fluctuation and β-adrenergic elevation of cyclic AMP in mouse epidermis in vivo
379. Hyperplastic transformation and tumor promotion in mouse epidermis: Possible consequences of disturbances of endogenous mechanisms controlling proliferation and differentiation
380. Prostaglandin synthetase dependent activation of 7,8-dihydro-7,8-dihydroxybenzo[a]pyrene to mutagenic derivatives
381. Tumor suppressor genes
382. Activation of c-Ha-ras-1 proto-oncogene by in vitro modification with a chemical carcinogen, benzo[a]pyrene diol-epoxide
383. Free radical intermediates produced by the autoxidation of 1,8-dihydroxy-9-anthrone (dithranol) in pyridine
384. Free radicals by autooxidation of anthralin and its 10-acyl analogues
385. In vitro binding of β-propiolactone to calf thymus DNA and mouse liver DNA to form 1-(2-carboxy-ethyl)adenine
386. Ultraviolet-B (290–320 nm)-irradiation inhibits epidermal growth-factor binding to mammalian cells
387. Two independent growth factor-generated signals regulate c-fos and c-myc mRNA levels in Swiss 3T3 cells
388. Double-stranded DNA stereoselectively binds benzo[a]pyrene diol-epoxides
389. Benzo[a]pyrene diol-epoxide covalently binds deoxyguanosine and deoxyadenosine in DNA
390. Catechol induced alterations in metabolic activation and binding of enantiomeric and racemic 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrenes to DNA in mouse skin
391. Catechol induced alterations in metabolic activation and binding of enantiomeric and racemic 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrenes to DNA in mouse skin
392. Effects of catechol on the induction of tumors in mouse skin by 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrenes
393. Calcium-dependent proteases: an enzyme system active at cellular membranes
394. Independent mechanisms for tumor promoters phenobarbital and 12-O-tetradecanoylphorbol-13-acetate in reduction of epidermal growth factor binding by rat hepatocytes
395. Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential address
396. The metabolic activation and nucleic acid adducts of naturally occurring carcinogens: recent results with ethyl carbamate and the spice flavors sariole and estrogole
397. Hyperthermia and phorbol ester tumor promotion in mouse skin
398. Tumorigenesis and carcinogenesis in mouse skin treated with hyperthermia during stage I and stage II of tumor promotion
399. The effect of 12-O-tetradecanoylphorbol-13-acetate TPA on cell transformation by simian virus 40 mutants
400. Epidermal ornithine decarboxylase induction and mouse skin tumor promotion by quinones
401. Evidence that a slowly cycling subpopulation of adult murine epidermal cells retains carcinogen
402. Quantitation of primary in vitro clonogenic keratinocytes from normal adult murine epidermis, following initiation, and during promotion of epidermal tumors
403. Subpopulations of primary adult murine epidermal basal cells sedimented on density gradients
404. A developing factor in experimental blastogenesis
405. The relationship of alterations in phospholipid metabolism to the mechanism of action of phorbol ester tumor promoters
406. The effect of the phorbol ester tumor promoters on the basal and catecholamine-stimulated levels of cyclic adenosine 3′,5′-monophosphate in mouse skin and epidermis in vivo
407. Effets of 12-O-tetradecanoylphorbol-13-acetate and mezerein on epidermal ornithine decarboxylase activity, isoproterenol-stimulated levels of cyclic adenosine 3′,5′-monophosphate, and induction of mouse skin tumors in vivo
408. Protection against 3-methylcholanthrene-induced skin tumorgenenisis in BALB/c mice by ellagic acid
409. Inhibition of methylcholanthrene-induced skin tumorigenesis in BALB/c mice by chronic oral feeding of trace amounts of ellagic acid in drinking water
410. Appearance of dark keratinocytes following intracutaneous injection of cholera toxin in mouse skin
411. Irritation, staining and antipsoriatic activity of 10-acyl analogues of anthralin
412. 3H]phorbol 12,13-dibutyrate binding to brain
413. Characterization of covalently modified deoxyribonucleosides formed from dibenz[a,j]anthracene in primary cultures of mouse keratinocytes
414. Genetic background and development of skin tumors
415. Comparison of the histological changes in the skin of DBA/2 and C57BL/6 mice following exposure to various promoting agents
416. Susceptibility to phorbol ester skin tumor promotion in (C57BL/6 × DBA/2) F1 mice is inherited as an incomplete dominant trait: evidence for multi-locus involvement
417. 2 inhibitor
418. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced increase in vascular permeability in mouse skin by lipoxygenase inhibitors
419. Some properties of lupoxygenase activities in cytosol and microsomal fractions of mouse epidermal homogenate
420. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and epidermal ornithine decarboxylase activity in mouse skin by palmitoylcarnitine
421. Benzo[a]pyrene-DNA adduct formation and removal in mouse epidermis in vivo and in vitro: relationship of DNA binding to initiation of carcinogenesis
422. Pharmacogenetics: an approach to understanding chemical and biologic aspects of cancer
423. The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states
424. P-450 genes: structure, evolution and regulation
425. The Ah locus: genetic regulation of the metabolism of carcinogens, drugs, and other environmental chemicals by cytochrome P-450-mediated monooxygenases
426. Aryl hydrocarbon hydroxylase, epoxide hydrase, and 7,12-dimethylbenz[a]anthracene produced skin tumorigenesis in the mouse
427. Genetic differences in mouse cytochrome P1-450-mediated metabolism of benzo[a]pyrene in vitro and carcinogenic index in vivo
428. The Ah locus: genetic regulation of the enzymes which metabolize polycyclic hydrocarbons and the risk for cancer
429. Effect of inhibitors of tumor promotion on 12-O-tetradecanoylphorbol-13-acetate-induced keratin modification in mouse epidermis
430. Tumorigenesis of diesel exhaust, gasoline exhaust, and related emission extracts on SENCAR mouse skin
431. Phorbol diester receptor copurifies with protein kinase C
432. Phospholipid degradation and signal translation for protein phosphorylation
433. Perspectives on the role of protein kinase C in stimulus-response coupling
434. The molecular heterogeneity of protein kinase C and its implications for cellular regulation
435. Studies and prospectives of protein kinase C family for cellular regulation
436. The induction of ornithine decarboxylase as an early possibly obligatory event in mouse skin carcinogenesis
437. Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumor-promoting agents
438. Induction of the polyamine-biosynthetic enzymes in mouse epidermis and their specificity for tumor promotion
439. Malignant progression of mouse skin papillomas treated with ethylnitrosourea, N-methyl-N′-nitro-N-soguanidine, or 12-O-tetradecanoylphorbol-13-acetate
440. Enhanced malignant progression of mouse skin tumors by the free-radical generator benzoyl peroxide
441. Regulatory gene product of the Ah locus. Characterization of the cytosolic inducer-receptor complex and evidence for its nuclear translocation
442. The structure, expression, and properties of additional members of the protein kinase C family
443. Protein kinase C ζ subspecies from rat brain: Its structure, expression, and properties
444. Tetradecanoyl-phorbol-13-acetate promotes tumors prior to initiation in two-stage promotion
445. A phorbol ester receptor/protein kinase, nPKCη, a new member of the protein kinase C family predominantly expressed in lung and skin
446. 7-position of guanine moieties
447. Minor products from the reaction of (+) and (-) benzo[a]-pyrene-anti-diolepoxide with DNA
448. The reaction of a 3-methylcholanthrene diol epoxide with DNA in relation to the binding of 3-methylcholanthrene to the DNA of mammalian cells
449. Transmembrane signalling at the epidermal growth factor receptor
450. Protein kinase C phosphorylates a component of NADPH oxidase of neutrophils
451. 1 events and regulation of cell proliferation
452. Defective responses of transformed keratinocytes to terminal differentiation stimuli. Their role in epidermal tumour promotion by phorbol esters and by deep skin wounding
453. Chalones revisited—a possible role for transforming growth factor β in tumour promotion
454. Tumor promoters induce mitotic aneuploidy in yeast
455. ‘Dark cells’ in normal, hyperplastic, and promoter-treated mouse epidermis studied by conventional and high-voltage electron microscopy
456. Production of TGFα and TGFβ by cultured keratinocytes, skin, and oral squamous carcinomas: potential autocrine regulation of normal and malignant epithelial cell proliferation
457. On the biochemical mechanism of tumorigenesis in mouse skin. II. Early effects on the biosynthesis of nucleic acids induced by initiating doses of DMBA and by promoting doses of phorbol-12,13-diester TPA
458. Influence of sendai virus on carcinogenesis in strain A mice
459. 6-alkylguanine necessary for initiation of carcinogenesis by alkylating agents?
460. Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis
461. Epidermal papillomas and carcinomas induced in unitiated mouse skin by tumor promoters alone contain a point mutation in the 61st codon of the Ha-ras oncogene
462. Characterization of the hydroperoxide response observed in mouse skin treated with tumor promoters in vivo
463. Stimulation of hydroperoxide generation in mouse skins treated with tumor-promoting or carcinogenic agents in vivo and in vitro
464. Phorbol ester tumor promoters and multistage skin carcinogenesis
465. Inhibitor effects of glutathione level-raising agents and D-α-tocopherol on ornithine decarboxylase induction and mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate
466. Inhibition of the effects of 12-O-tetradecanoylphorbol-13-acetate on mouse epidermal glutathione peroxidase and ornithine decarboxylase activities by glutathione level-raising agents and selenium-containing compounds
467. Decreased ratio of reduced/oxidized glutathione in mouse epidermal cells treated with tumor promoters
468. Effects of combined treatments with selenium, glutathione, and vitamin E on glutathione peroxidase activity, ornithine decarboxylase induction and complete and multistage carcinogenesis in mouse skin
469. Inhibition of multistage tumor promotion in mouse skin by diethyldithiocarbamate
470. Skin tumorigenesis research data base
471. A human retinoic acid receptor which belongs to the family of nuclear receptors
472. Cancer and aging in mice and man
473. Cytogenetic effects caused by phorbol ester tumor promoters in primary mouse keratinocytes: correlation with the convertogenic activity of TPA in multistage skin carcinogenesis
474. Ras gene mutation and amplification in human nonmelanoma skin cancers
475. Ras gene mutations in ultraviolet radiation-induced mouse skin tumors
476. Induction of transforming growth factor-α expression in human keratinocytes by phorbol esters
477. Cytochrome P-450 content and mixed-function oxidase activity in microsomes isolated from mouse skin
478. Ethoxycoumarin-o-deethylation activity in viable basal and differentiated keratinocytes isolated from the skin of the hairless mouse
479. 2+-dependent proteolysis of the Ah receptor
480. Tumor-promotion by TCDD in skin of HRS/J hairless mice
481. Stem cells in epidermis from the back of the mouse
482. Induced cell proliferation and the initiation of skin tumor formation in mice by ultraviolet light
483. The role of free radical reactions in biological systems
484. A measure of the stimulating effect of simple injury combineed with carcinogenic chemicals on tumor formation in mice
485. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis
486. Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo
487. Ultrastructural histological, and biochemical alterations produced by 12-O-tetradecanoylphorbol-13-acetate on mouse epidermis and their relevance to skin tumor promotion
488. Late ultrastructural changes induced by 12-O-tetradecanoylphorbol-13-acetate in mouse epidermis and their reversal
489. Ultrastructural and biochemical changes induced in mouse epidermis by a hyperplastic agent, ethylphenylpropiolate
490. Stimulation of the phosphorylation of mouse epidermal histones by tumor-promoting agents
491. Stimulation of the synthesis of the H1 and H3 histone fractions of mouse epidermis by 12-O-tetradecanoylphorbol-13-acetate
492. Influence of dose of initiator on two-stage skin carcinogenesis in BALB/c mice with cellular mosaicism
493. Studies of skin tumorigenesis in PGK mosaic mice: many promoter-independent papillomas and carcinomas do not develop from pre-existing promoter-dependent papillomas
494. Review of the current status of calcium and thiols in cellular injury
495. Effect of dietary lipid on UV light carcinogenesis in the hairless mouse
496. Effects of tumor promoters on the rate and commitment to terminal differentiation of subpopulatons of murine keratinocytes
497. Murine susceptibility to two-stage skin carcinogenesis is influenced by the agent used for promotion
498. Tumor copromoting activity of λ-interferon in the murine skin multistage carcinogenesis mode
499. 2+ concentration
500. Distribution of constitutive and polycyclic aromatic hydrocarbon-induced cytochrome P-450 activities in murine epidermal cells that differ in their stages of differentiation
501. Assessment of the antioxidant/prooxidant status of murine skin following topical treatment with 12-O-tetradecanoylphorbol-13-acetate and throughout the ontogeny of skin cancer. Part II: quantitation of glutathione and glutathione disulfide
502. Assessment of the antioxidant/prooxidant status of murine skin following topical treatment with 12-O-tetradecanoylphorbol-13-acetate and throughout the ontogeny of skin cancer. Part I: quantitation of superoxide dismutase, catalase, glutathione peroxidase and xanthine oxidase
503. The influence of phorbol myristate acetate on oxygen consumption by polymorphonuclear leukocytes
504. Major differences between lung, skin and liver in the microsomal metabolism of homologous series of resorufin and coumarin ethers
505. 2+ release from mitochondria induced by prooxidants
506. Orally administered 2-acetylaminofluorene as an initiator and as a promoter in epidermal carcinogenesis in the mouse
507. Transforming growth factor-β: possible roles in carcinogenesis
508. Cellular responses to carcinogen-induced DNA damage and the role in DNA repair
509. Activation of some aromatic amines to mutagenic products by prostaglandin endoperoxide synthetase
510. On the persistence of tumour initiation and the acceleration of tumour progression in mouse skin tumorigenesis
511. The stimulation of phospholipid metabolism in mouse skin following phorbol ester treatment
512. Keratin gene expression in mouse epidermis and cultured epidermal cells
513. An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue
514. Differential effects of phorbol esters on c-fos and c-myc and ornithine decarboxylase gene expression in mouse skin in vivo
515. Effect of exogenous glutathione on tumor progression in the murine skin multistage carcinogenesis model
516. A possible role for free radicals in tumor progression
517. Conditional neoplasms and subthreshold neoplastic states A study of the tar tumors of rabbits
518. Alterations of the p53 tumor suppressor gene during mouse skin tumor progression
519. Tumor suppressor genes: the puzzle and the promise
520. Identification of phorbol ester receptors in T-growth factor-producing and nonproducing EL4 mouse thymoma cells
521. 2 phase repair of radiation-induced chromatin damage in the SENCAR mouse
522. Measurement of unscheduled DNA synthesis in primary cultures of adult mouse epidermal keratinocytes
523. Expression, purification, and characterization of protein kinase C-ϵ
524. Role of depurination in mutagenesis by chemical carcinogens
525. Fluocinolone acetonide: A potent inhibitor of mouse skin tumor promotion and epidermal DNA synthesis
526. Changes in regional keratin polypeptide patterns during phorbol ester-mediated reversible and permanently sustained hyperplasia of mouse epidermis
527. Tumor initiation and promotion
528. Evidence for a new model of tumor progression from carcinogenesis and tumor promotion studies with 7-bromomethylbenz(a)anthracene
529. Separation of initiating and promoting effects of the skin carcinogen, 7-bromomethylbenz(a)anthracene
530. The isolation and characterization of 3-(2-carboxyethyl) cytosine following in vitro reaction of β-propiolactone with calf thymus DNA
531. Metabolism of benzo[a]pyrene. Effect of 3-methylcholanthrene pretreatment on metabolism by microsomes from lungs of genetically “responsive” and “nonresponsive” mice
532. Relationship of selenium to cancer. I. Inhibitory effect of selenium on carcinogenesis
533. Protection against cocarcinogenesis by antioxidants
534. Competitive inhibition of diacyglycerol of specific phorbol ester binding
535. Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter
536. Reversible inhibition of normal human prokeratinocyte proliferation by type beta transforming growth factor-growth inhibitor in serum-free medium
537. Specific high affinity cell membrane receptors for biologically active phorbol and ingenol esters
538. Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors
539. The growth potentialities of induced skin tumors in mice. The effects of different methods of chemical carcinogenesis
540. The life and progression of induced skin tumors in mice
541. Latent carcinogenic action of beta-irradiation on mouse epidermis
542. Chemical carcinogenesis
543. 6 of guanine is only one of many chemical events that may initiate carcinogenesis
544. O-Alkyl pyrimidines in mutagenesis and carcinogenesis: occurrence and significance
545. Site-specific mutagenesis: retrospective and prospective
546. Correlation between sensitivity to tumor promotion and sustained epidermal hyperplasia of mice and rats treated with 12-O-tetradecanoylphorbol- 13-acetate
547. Cancer: etiology, mechanisms, and prevention—a summary
548. Overview of tumor promotion in animals
549. Mechanisms involved in two-stage carcinogenesis in mouse skin
550. Multistage skin tumor promotion and specificity
551. Mechanisms involved in multistage skin tumorigenesis
552. Cellular and molecular mechanisms involved in multistage skin carcinogenesis
553. Inhibition of chemical carcinogenesis
554. Strain differences and solvent effects in mouse skin carcinogenesis experiments using carcinogens, tumor initiators and promoters
555. Initiation-promotion versus complete skin carcinogenesis in mice: Importance of dark basal keratinocytes (stem cells)
556. SENCAR mouse skin tumorigenesis
557. Inhibition of tumor initiation and promotion by anti-inflammatory agents
558. Macromolecular synthesis following a single application of alkylating agents used as initiators of mouse skin tumorigenesis
559. Macromolecular synthesis following a single application of polycyclic hydrocarbons used as initiators of mouse skin tumorigenesis
560. Acetic acid, a potent stimulator of mouse epidermal macromolecular synthesis and hyperplasia but with weak tumor-promoting ability
561. The effects of weak or non-carcinogenic polycyclic hydrocarbons on 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene skin tumor-initiation
562. Studies on the mechanism of skin tumor promotion: evidence for several stages in promotion
563. Studies on mechanism of action of anti-tumor-promoting agents: their specificity in two-stage promotion
564. Skin tumor-promoting activity of benzoyl peroxide, a widely used free radical-generating compound
565. Comparison of complete carcinogenesis and tumor initiation and promotion in mouse skin: the induction of papillomas by tumor initiation-promotion, a reliable short term assay
566. Studies on the mechanisms involved in multistage carcinogenesis in mouse skin
567. Specificity and mechanisms of promoter inhibitors in multistage promotion
568. Studies on the mechanism of action of antitumor promoting agents: Suggestive evidence for the involvement of free radicals in promotion
569. sn-1,2-Diacylglycerols mimic the effects of 12-O-tetradecanoylphorbol-13-acetate in vivo by inducing biochemical changes associated with tumor promotion in mouse epidermis
570. Inhibition of 12-O-tetradecanoylphorbol-13-acetate induction of ornithine decarboxylase activity, DNA synthesis, and tumor promotion in mouse skin by ascorbic acid and ascorbyl palmitate
571. Synthetic lipid second messenger sn-1,2-didecanoylglycerol: a complete promoter in mouse skin
572. Benzo[e]pyrene-induced alterations in the binding of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene to DNA in SENCAR mouse epidermis
573. Specific binding of phorbol ester tumor promoters to intact primary epidermal cells from SENCAR mice
574. Diminution of mouse epidermal superoxide dismutase and catalase activities by tumor promoters
575. Down regulation of specific binding of [20-3H]phorbol-12,13-dibutyrate and pphorbol ester-induced differentiation of human promyelocytic leukemia cells
576. Autocrine growth factors and cancer
577. Human tumor suppressor genes
578. Ultraviolet light irradiation as an initiating agent in skin tumor formation by two-stage method
579. Present status of the concept of promoting action of cocarcinogenesis in skin
580. Effect of ALS or ATS administration on tumor formation in two-stage skin carcinogenesis
581. Puva and the induction of skin cancer
582. Identification of the major adducts formed by reaction of benzo[a]pyrene diolepoxide with DNA in vitro
583. Host cell reactivation studies with epidermal cells of mice sensitive and resistant to carcinogenesis
584. Tumor induction in SENCAR mice in response to ultraviolet radiation
585. Enhancement of two-stage skin carcinogenesis by exposure of distant skin to radiation
586. Existence of an optimal dose of dihydroteleocidin B for skin tumor promotion
587. Okadaic acid: An additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter
588. Specific binding of okadaic acid, a new tumor promoter in mouse skin
589. Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin
590. Potent tumor promoters other than phorbol ester and their significance
591. 1 stimulates lipid synthesis in cell cultures
592. DNA photoreactivating enzyme from placental mammals: origin and characteristics
593. Pyrimidine dimer formation and repair in human skin
594. Tumor promotion by a hydroperoxide metabolite of butylated hydroxytoluene, 2,6-di-tert-butyl-4-hydroperoxy-4-methyl-2,5-cyclohexadienone, in mouse skin
595. Generation of free radicals from organic hydroperoxide tumor promoters in isolated mouse keratinocytes
596. Generation of reactive intermediates from tumor promoter butylated hydroxytoluene hydroperoxide in isolated murine keratinocytes or by hematin
597. Repair of ultraviolet light damage of the DNA of cultured human epidermal keratinocytes and fibroblasts
598. Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool, and not an inositol phosphate, regulates calcium fluxes at the plasma membrane
599. Oligodeoxynucleotides containing synthetic abasic sites
600. Polyamine biosynthesis and skin tumor promotion. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase α-difluoromethyl-ornithine
601. Relationship of body weight to cancer incidence
602. Mechanisms of cocarcinogenesis involving endogenous retroviruses
603. Radiation-induced DNA damage and its repair
604. A study of skin carcinogenesis in the mouse with single applications of 910-dimethyl-12-benzathracene at different dosages
605. 2+-ATPase
606. Mouse epidermal aryl hydrocarbon hydroxylase
607. The effects of dexamethasone on mouse skin tumor-initiation and aryl hydrocarbon hydroxylase
608. Failure of phorbol ester TPA to enhance sister chromatid exchanges, mitotic segregations or expression of mutations in chinese hamster cells
609. The mechanism of bromobenzene-induced cytotoxicity studied with isolated hepatocytes
610. A cytoplasmic protein stimulates normal N-ras p21 GTPase but does not affect oncogenic mutants
611. Tumorigenesis in mouse skin: inhibition by synthetic inhibitors of proteases
612. The role of free oxygen radicals in tumor promotion and carcinogenesis
613. Anticarcinogenic action of protease inhibitors
614. The role of DNA repair and somatic mutation in carcinogenesis
615. Ion regulation, cell injury and carcinogenesis
616. Influence of dose on skin tumor induced in mice by single application of 7,12-dimethylbenz[a]anthracene
617. Comparative activity of some carcinogenic hydrocarbons
618. Signal transduction by receptors with tyrosine kinase activity
619. Interactions of radiation and chemical carcinogens
620. Possible mechanism of phorbol ester-induced maturation of human promyelocytic leukemia cells
621. Tumor-promoting agents in two-stage carcinogenesis
622. Cocarcinogenic and tumor-promoting agents in tobacco carcinogenesis
623. The tumor-enhancing principles of Croton tiglium L
624. The effect of aging and interval between primary and secondary treatment in two-stage carcinogenesis on mouse skin
625. Effect of aging in two-stage carcinogenesis on mouse skin with phorbol myristate acetate as promoting agent
626. Structure-activity relationships of tumor promoters and cocarcinogens and interaction of phorbol myristate acetate and related esters with plasma membranes
627. N-ras mutations in human cutaneous melanoma from sun-exposed body sites
628. Inhibition of both stage I and stage II mouse skin tumor promotion by retinoic acid and the dependence of inhibition of tumor promotion on the duration of retinoic acid treatment
629. Inhibition of tumor promoter 12-O-tetradecanoylphorbol-13-acetate-induced synthesis of mouse epidermal ornithine decarboxylase messenger RNA and diacyglycerol-promoted mouse skin tumor formation by retinoic acid
630. Effects of dose and duration of treatment with the tumor-promoting agent, 12-O-tetradecanoylphorbol-13-acetate on mouse skin carcinogenesis
631. The effect of benzo[a]pyrene on the basal and isoproterenol-stimulated levels of cyclic adenosine 3′,5′-cyclic monophosphate in mouse epidermis in vivo
632. Induction of mouse epidermal ornithine decarboxylase activity and DNA synthesis by ultraviolet light
633. Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and of skin promotion
634. Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity the accumulation of prostaglandins, and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate
635. Induction of mouse epidermal ornithine decarboxylase activity and skin tumors by 7,12-dimethylbenz[a]anthracene: modulation by retinoic acid and 7,8-benzoflavone
636. Inhibition of 7-bromomethylbenz[a]anthracene-promoted mouse skin tumor formation by retinoic acid and dexamethasone
637. Modulation of mouse skin tumor promotion by dietary 13-cis-retinoic acid and α-difluromethylornithine
638. Increased mouse epidermal ornithine decarboxylase activity by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate involves increased amounts of both enzyme protein and messenger RNA
639. Involvement of protein kinase C activation in ornithine decarboxylase gene expression in primary culture of newborn mouse epidermal cells and in skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate
640. The effects of anti-inflammatory agents on mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation and production of plasminogen activator
641. Inhibition of the binding of 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene to DNA in mouse skin epidermis by 1-ethynylpyrene
642. Genetic alterations during colorectal tumorigenesis
643. Genetic alterations during colorectal tumor development
644. Mutations activating human c-Ha-ras-l-protooncogene (HRAS1) induced by chemical carcinogens and depurination
645. Signal transduction in proliferating normal and transformed cells
646. Phorbol ester tumor promoter treated epidermis, papillomas, carcinomas, and tumor derived epidermal cell lines have decreased levels of the glucocorticoid receptor
647. Increase in histidine decarbocylase activity in mouse skin after application of the tumor promoter tetradecanoylphorbol acetate
648. Palytoxin down-modulates the epidermal growth factor receptor through a sodium-dependent pathway
649. Inhibition of phorbol ester-induced polyamine accumulation in mouse epidermis by anti-inflammatory steroid
650. α-Difluoromethyl-ornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter induced polyamine accumulation and carcinogenesis in mouse skin
651. The role of polyamines in tumor promotion
652. Aryl hydrocarbon (benzo[a]pyrene) hydroxylase a mixed-function oxygenase in mouse skin
653. The action of oncogenes in the cytoplasm and nucleus
654. Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis
655. Protein kinase, phospholipid and control of growth
656. The origins of human cancer: molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment
657. In vitro inhibition of mouse epidermal cell lipoxygenase by flavonoids: Structure-activity relationships
658. Pharmaceutical formulations of anthralin
659. Integrated control of growth and differentiation of normal human prokeratinocytes cultured in serum-free medium: clonal analyses, growth kinetics, and cell cycle studies
660. A study of tobacco carcinogenesis. VIII. The role of the acidic fractions as promoters
661. Tumor promotion and cocarcinogenesis as related to man and his environment
662. Excision repair of mouse and human fibroblast cells, and a factor affecting the amount of UV-induced unscheduled DNA synthesis
663. Differential inhibition by staurosporine, a potent kinase C inhibitor, of 12-O-tetradecanoylphorbol-13-acetate-caused skin tumor promotion epidermal ornithine decarboxylase induction, hyperplasia and inflammation
664. Cellular and molecular changes during chemical carcinogenesis in mouse skin cells
665. Altered differentiation of mouse epidermal cells treated with retinyl acetate in vitro
666. Mouse skin cells resistant to terminal differentiation associated with initiation of carcinogenesis
667. Chemical carcinogenesis: from animal models to molecular models in one decade
668. Phorbol esters stimulate DNA synthesis and ornithine decarboxylase activity in mouse epidermal cell cultures
669. The study of tumor promotion in a cell culture model for mouse skin—A tissue that exhibits multistage carcinogenesis in vivo
670. Direct mutagenesis of Ha-ras-1 oncogene by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats
671. Active oxygen acts as a promoter of transformation in mouse embryo C3H/10Tl/2 fibroblasts
672. Persisting oncogenic herpes virus induced by the tumor promoter TPA
673. Tumor initiators and promoters in the induction of Epstein-Barr virus