The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

Cell

Volumn 70, Issue 3, 1992, Pages 431-442

  Lowenstein, E J ^a   Daly, R J ^a   Batzer, A G ^a   Li, W ^a   Margolis, B ^a   Lammers, R ^b   Ullrich, A ^c   Skolnik, E Y ^a   Bar Sagi, D ^b   Schlessinger, J ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c Simons Center for Quantitative Biology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR; GROWTH FACTOR RECEPTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE;

AMINO ACID SEQUENCE; ARTICLE; DNA SYNTHESIS; FIBROBLAST; IMMUNOBLOTTING; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; ONCOGENE RAS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; BLOTTING, NORTHERN; BLOTTING, WESTERN; CAENORHABDITIS; CELL LINE; DNA; HUMAN; MICE; MICROINJECTIONS; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEIN P21(RAS); PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTEIN-TYROSINE KINASE; PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, CELL SURFACE; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

MAMMALIA;

EID: 0026729382     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(92)90167-B     Document Type: Article

References (56)

1. The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily
2. Induction of membrane ruffling in fluid phase pinocytosis in quiescent fibroblasts by ras proteins
3. High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody and appears necessary for early responses
4. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
5. Characterization and cDNA cloning of phospholipase C-γ, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase
6. Oncogenes and signal transduction
7. High-efficiency transformation of mammalian cells by plasmid DNA
8. C. elegans cell-signaling gene sem-5 encodes a protein with SH2 and SH3 domains
9. A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine
10. cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor
11. Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells
12. Recognition of protein coding regions in DNA sequences
13. Purification and characterization of human H-ras protein expressed in Escherichia coli
14. SH2 domains: elements that control protein interactions during signal transduction
15. Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing
16. Multiple intercellular signaling systems control the development of the Caenorhabditis elegans vulva
17. Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors
18. Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins
19. Phosphorylation of the PDGF receptor β subunit creates a tight binding site for phosphatidylinositol 3 kinase
20. PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254
21. Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3′-S-monophosphate-dependent protein kinase
22. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins
23. The scanning model for translation: an update
24. Substrate specificity determinants for casein kinase II as deduced from studies with synthetic peptides
25. Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3
26. Tyrosine phosphorylation of a common 57 kd protein in growth factor-stimulated and transformed cells
27. Proteins with SH2 SH3 domains: transducers in the tyrosine kinase signaling pathway
28. EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling
29. Tyrosine kinase activity is essential for the association of phospholipase C-γ with the epidermal growth factor receptor
30. The tyrosine-phosphorylated carboxy terminus of the EGF receptor is a binding site for GAP and PLC-γ
31. Tyrosine phosphorylation of vav protooncogene product containing SH2 and SH3 domain and transcription factors motifs
32. Site specificity of casein kinase-2 (TS) from rat liver cytosol: a study with model peptide substrates
33. A novel viral oncogene with structural similarity to phospholipase C
34. Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo
35. SH2 domains of signaling proteins control specificity of binding to growth factor receptors
36. Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro
37. A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (flg) is a binding site for the SH2 domain of phospholipase C-γ1
38. A point mutation at Tyr766 of FGF receptor eliminates FGF-induced tyrosine phosphorylation of PLC-γ and phosphatidylinositol hydrolysis without affecting mitogenesis
39. Increase of the catalytic activity of phospholipase C-γ1 by tyrosine phosphorylation
40. c-src complexes, and PI3-kinase
41. Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3′-kinase SH2 domains: a model for SH2-mediated receptor-target interactions
42. SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of tyr 992 as the high-affinity binding site for SH2 domains of phospholipase Cγ
43. Presence of SH2 domains of phospholipase Cγ1 enhances substrate phosphorylation by increasing the affinity toward the EGF-receptor
44. Arg-Gly-Asp: a versatile cell recognition signal
45. A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus p130gag-fps
46. Signal transduction by allosteric receptor oligomerization
47. Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases
48. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione-S-transferase
49. Sequence similarity of phospholipase C with the non-catalytic region of src
50. Inositol phospholipid-specific phospholipase C complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products
51. Molecular cloning of two GAP complementary DNA from human placenta
52. Signal transduction by receptors with tyrosine kinase activity
53. Cloning of bovine GAP and its interaction with oncogenic ras
54. Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium
55. Fluorescent localization of contractile proteins in tissue culture cells
56. Substrate specificity of protein kinase C: use of synthetic peptides corresponding to physiological sites cis probes for substrate recognition requirements