Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas

The Lancet

Volumn 340, Issue 8820, 1992, Pages 626-630

  Cottrell, S ^a   Bodmer, W F ^a   Bicknell, D ^b   Kaklamanis, L ^c  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOMATOUS POLYP; ARTICLE; CLINICAL ARTICLE; COLON CARCINOMA; COLON POLYPOSIS; CONTROLLED STUDY; DELETION MUTANT; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; MOLECULAR GENETICS; MUTATION; POINT MUTATION; PRIORITY JOURNAL;

ADENOMATOUS POLYPOSIS COLI; BASE SEQUENCE; BLOTTING, SOUTHERN; CHROMOSOME DELETION; COLORECTAL NEOPLASMS; DNA; DNA MUTATIONAL ANALYSIS; DNA TRANSPOSABLE ELEMENTS; GENE FREQUENCY; GENETIC COUNSELING; GENETIC SCREENING; HUMAN; MOLECULAR SEQUENCE DATA; MUTATION; PEDIGREE; RESTRICTION MAPPING;

EID: 0026726952     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/0140-6736(92)92169-G     Document Type: Article

References (30)

1. Localization of the gene for familial adenomatous polyposis on chromosome 5
2. The gene for familial polyposis coli maps to the long arm of chromosome 5
3. Identification of FAP locus genes from chromosome 5q21
4. Identification and characterization of the familial adenomatous polyposis coli gene
5. Presymptomatic diagnosis of familial adenomatous polyposis by bridging DNA markers
6. Linked DNA markers for presymptomatic diagnosis of familial adenomatous polyposis
7. A CA repeat 30-70 kb downstream from the adenomatous polyposis coli (APC) gene
8. SspI polymorphism in sequence encoding 3' untranslated region of the APC gene
9. Two intragenic polymorphisms of the APC-gene detected by PCR and enzymatic digestion
10. Two MspI polymorphisms within the APC gene
11. Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms
12. Rapid detection of single base pair mismatches as heteroduplexes on Hydrolink gels
13. Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients
14. Identification of deletion mutations and three new genes at the familial polyposis locus
15. Detecting single base substitutions as heteroduplex polymorphisms
16. Establishment of a human carcinoembryonic antigen-producing colon adenocarcinoma cell line
17. Establishment and characterization of human colorectal cancer cell lines
18. The isolation and characterization of colorectal epithelial cell lines at different stages in malignant transformation from familial polyposis coli patients
19. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
20. 2
21. TP53 tumour suppressor gene: a model for investigating human mutagenesis
22. Reactivity of cytosine and thymine in single-base-pair mismatches with hydroxylamine and osmium tetroxide and its application to the study of mutations
23. Report of the committee on chromosome changes in neoplasia
24. Loss of heterozygosity involving the APC and MCC genetic-loci occurs in the majority of human esophageal cancers
25. Loss of heterozygosity affecting the p53, Rb, and mcc/apc tumor suppressor gene loci in dysplastic and cancerous ulcerative-colitis
26. Polymorphic sites within the MCC and APC loci reveal very frequent loss of heterozygosity in human small-cell lung-cancer
27. Hereditary colorectal cancer: a commentary
28. Introduction
29. Pedigree analysis of susceptibility to colonic adenomas
30. Classification of human colorectal adenocarcinoma cell lines