The cytotoxicity, DNA crosslinking ability and DNA sequence selectivity of the aniline mustards melphalan, chlorambucil and 4-[bis(2-chloroethyl)amino] benzoic acid

Biochemical Pharmacology

Volumn 44, Issue 1, 1992, Pages 59-64

  Sunters, Andrew ^a,b   Springer, Caroline J ^a,c   Bagshawe, Kenneth D ^a   Souhami, Robert L ^b   Hartley, John A ^b  

^a CHARING CROSS HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 BIS(2 CHLOROETHYL)AMINOBENZOIC ACID; ANILINE MUSTARD DERIVATIVE; CHLORAMBUCIL; MELPHALAN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL STRAIN K 562; COLON ADENOCARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA CROSS LINKING; DNA SEQUENCE; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

4-AMINOBENZOIC ACID; ALKYLATION; BINDING SITES; CELL SURVIVAL; CHLORAMBUCIL; CROSS-LINKING REAGENTS; DNA; HUMANS; MELPHALAN; NITROGEN MUSTARD COMPOUNDS; TUMOR CELLS, CULTURED;

EID: 0026724972     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(92)90038-K     Document Type: Article

References (20)

1. Antibody directed enzymes revive prodrugs concept
2. Comparison of half lives and cytotoxicity of N-mesyloxyethyl and N-chloroethyl-4-aminobenzoyl compounds, products of prodrugs in antibody-directed enzyme prodrug therapy (ADEPT)
3. Activation of prodrugs by antibody-enzyme conjugates, a new approach
4. A study of comparative chemical and biological activities of alkylating agents
5. Comparison of in vitro anticancer-drug screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumour cell lines
6. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability
7. An agarose gel method for the determination of DNA interstrand crosslinking applicable to the measurement of the rate of total and “second arm” crosslink
8. DNA sequence selectivity of N-7 alkylation by nitrogen mustards
9. Measurement of strand breaks and crosslinks in DNA by alkaline elution
10. Enzyme activated anti-tumour agents—III. Hydrolysis of conjugates of p-hydroxyaniline mustard in aqueous solution
11. Structure-activity relationships in antitumour aniline mustards
12. Biological aspects of DNA damage by crosslinking agents
13. Evidence for carrier-mediated transport of melphalan by L5178Y lymphoblasts in vitro
14. The selectivity of action of alkylating agents and drug resistance. 3. The uptake and degradation of alkylating drugs by Yoshida ascites sarcoma cells in vitro
15. The mechanism of the reaction of aryl nitrogen mustards with nucleophiles
16. Reaction mechanism of some aromatic nitrogen mustards
17. Molecular electrostatic potential of the nucleic acids
18. Mechanisms of selective alkylation of guanine N-7 positions by nitrogen mustards