Sumatriptan: A Review of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Efficacy in the Acute Treatment of Migraine and Cluster Headache

Drugs

Volumn 43, Issue 5, 1992, Pages 776-798

  Dechant, Kerry L ^a   Clissold, Stephen P ^a  

^a ADIS INTERNATIONAL LIMITED   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CAFFEINE; ERGOTAMINE; METOCLOPRAMIDE; SEROTONIN; SEROTONIN RECEPTOR; SUMATRIPTAN;

AGE; BRAIN BLOOD VESSEL; CAROTID ARTERY FLOW; CLUSTER HEADACHE; DRUG EFFICACY; DRUG HALF LIFE; FATIGUE; GASTROINTESTINAL SYMPTOM; HUMAN; INTRANASAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY DISEASE; LIVER DISEASE; MALAISE; MIGRAINE; MUSCLE WEAKNESS; NECK PAIN; NERVE CELL; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROPHYLAXIS; RECEPTOR BINDING; RECURRENT DISEASE; RESPIRATORY TRACT DISEASE; REVIEW; SEX DIFFERENCE; SUBCUTANEOUS DRUG ADMINISTRATION; SYMPTOMATOLOGY; TASTE DISORDER; VASOCONSTRICTION; VERTIGO;

ACUTE DISEASE; ANIMAL; CLUSTER HEADACHE; HUMAN; INDOLES; MIGRAINE; SEROTONIN; SULFONAMIDES; SUMATRIPTAN;

EID: 0026724789     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.2165/00003495-199243050-00010     Document Type: Article

References (85)

1. Plasma serotonin in migraine and stress
2. The safety and tolerability of sumatriptan: an overview
3. Evidence for 5-HT1B/1D receptors mediating the antimigraine effect of sumatriptan and dihy-droergotamine
4. The antimigraine drug, sumatriptan (GR43175), selectively blocks neurogenic plasma extravasation from blood vessels in dura mater
5. Indomethacin and acetylsalicylic acid block neurogenic plasma protein extravasation in rat dura mater
6. Treatment of acute migraine with subcutaneous sumatriptan
7. Hydroxytryptamine receptor profile in healthy and diseased human epicardial coronary arteries
8. 1-like receptor agonist
9. 2receptor activation
10. Serotonin receptors. Therapeutic prospects in cardiovascular disease
11. Total plasma serotonin, 5-hydroxyindoleacetic acid and p-hydroxy-m-methoxyman-delic acid excretion in normal and migrainous subjects
12. Oral sumatriptan in pharmacokinetics in the migrainous state
13. 14C-GR43175 in rat and dog
14. 1dreceptor agonism predicts antimigraine efficacy
15. 1-like receptors in the reduction of porcine cranial arteriovenous anastomotic shunting by sumatriptan
16. 1-like receptor agonist, for the acute treatment of severe migraine
17. Histamine and 5-hydroxytryptamine (serotonin) and their antagonists
18. Extracranial vascular changes and the source of pain in migraine headache
19. Subcutaneous sumatriptan in the acute treatment of migraine
20. The selective carotid arterial vasoconstrictor action of GR43175 in anaesthetized dogs
21. 1-like agonists in the treatment of migraine
22. The acute treatment of migraine with aura with sumatriptan
23. A placebo-controlled study of intranasal sumatriptan for the acute treatment of migraine
24. Effect of prophylactic migraine medications on the pharmacokinetic and pharmacodynamic profiles of sumatriptan
25. The clinical pharmacology, pharmacokinetics and metabolism of sumatriptan
26. 1-like agonist GR43175 in healthy volunteers
27. Migraine pain associated with middle cerebral artery dilatation: reversal by sumatriptan
28. Sumatriptan reverses the changes in calcitonin gene-related peptide seen in the headache phase of migraine
29. Release of vasoactive peptides in the extracerebral circulation of man and the cat during activation of the trigeminovascular system
30. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache
31. 3H]-dihydroergotamine binding sites in the cat central nervous system: relevance to migraine
32. Differential effects on the internal and external carotid circulation of the monkey evoked by locus coeruleus stimulation
33. Effect of stimulation of nucleus raphe dorsalis on carotid blood flow. I. The monkey
34. Stimulation of the superior sagittal sinus increases metabolic activity and blood flow in certain regions of the brainstem and upper cervical spinal cord of the cat
35. Oral sumatriptan in acute migraine
36. Mechanism of migraine headache and action of ergotamine tartrate
37. 1dbinding sites
38. On pain mechanisms in cluster headache
39. Preclinical studies on the anti-migraine drug, sumatriptan
40. The vasoconstrictor action of sumatriptan on human isolated dura mater
41. 1-like receptor in dog isolated saphenous vein
42. The macro- and microvasculature of the dura mater
43. Effect of serotonin in migraine patients
44. 1e) in human brain: interaction with a GTP-binding protein
45. Pia arachnoid contains substance P originating from trigeminal neurons
46. Comparative neuropharmacology of dihydroergotamine and sumatriptan (GR 43175)
47. The neurobiology of vascular head pain
48. Neuroeffector functions of sensory fibres: implications for headache mechanisms and drug actions
49. A randomized, double-blind comparison of sumatriptan and cafergot in the acute treatment of migraine
50. Focal headache during balloon inflation in the internal carotid and middle cerebral arteries
51. Sumatriptan — an oral dose-defining study
52. Evaluation of a multiple-dose regimen of oral sumatriptan for the acute treatment of migraine
53. 1-like receptors mediate 5-hydroxytryptamine-induced contraction of human isolated basilar artery
54. 1dbinding sites
55. The selective closure of feline carotid arteriovenous anastomoses (AVAs) by GR43175
56. 1dsubtype
57. Overview of initial clinical studies with intravenous and oral GR43175 in acute migraine
58. Methodology of clinical trials of sumatriptan in migraine and cluster headache
59. Experimental studies on headache. Pain-sensitive structures of the head and their significance in headache
60. Ergot alkaloids block neurogenic extravasation in dura mater: proposed action in vascular headaches
61. 1-like receptor agonists and the pathophysiology of migraine
62. Cardiovascular effects of serotonin agonists and antagonists
63. 5-Hydroxytryptamine: a chameleon in the heart
64. 1Dreceptors
65. Lack of an interaction between propranolol and sumatriptan
66. Prophylactic and therapeutic properties of 1-methylysergic acid butanolamide in migraine: preliminary report
67. Biochemical investigations in headache: Increase in the hydroxyindoleacetic acid excretion during migraine attacks
68. Lack of antinociceptive activity of sumatriptan in rodents
69. In vivo
70. Clinical pharmacokinetics of cimetidine
71. Pizotifen (BC-105): a review of its pharmacological properties and its therapeutic efficacy in vascular headaches
72. Treatment of migraine attacks with sumatriptan
73. Self-treatment of acute migraine with subcutaneous sumatriptan using an auto-injector device
74. Treatment of acute cluster headache with sumatriptan
75. 1dbinding sites in porcine brain can be sub-divided by GR43175
76. Innervation of the feline cerebral vasculature by nerve fibres containing calcitonin gene-related peptide: trigeminal origin and co-existence with substance P
77. 1d) in the human brain by autoradiography
78. 1dagent in monkey and human brains as shown by autoradiography
79. Stimulation of cranial vessels excites nociceptive neurones in several thalamic nuclei of the cat