Dietary vitamin E and the attenuation of early lesion development in modified Watanabe rabbits

Atherosclerosis

Volumn 94, Issue 2-3, 1992, Pages 153-159

  Williams, Robert J ^a   Motteram, Joanne M ^a   Sharp, Catriona H ^a   Gallagher, Patrick J ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Hypercholesterolemic; LDL; LDL receptor deficiency; Oxidative modification; Vitamin E; WHHL rabbits

Indexed keywords

ALPHA TOCOPHEROL; LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; DIET; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RABBIT;

ANIMAL; AORTA; CHOLESTEROL; COPPER; DIET; HYPERLIPIDEMIA; LIPIDS; LIPOPROTEINS, LDL; MALE; OXIDATION-REDUCTION; RABBITS; VITAMIN E;

EID: 0026717156     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/0021-9150(92)90240-H     Document Type: Article

References (24)

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2. Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: Evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit
3. Deficiency of low density lipoprotein receptors in liver and adrenal gland of WHHL rabbits: an animal model of familial hypercholesterolemia
4. A novel mechanism by which probucol lowers low density lipoprotein levels demonstrated in the LDL receptor-deficient rabbit
5. Role of oxidized low density lipoprotein in atherogenesis
6. Probucol inhibits oxidative modification of low density lipoprotein
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8. Lack of effect of probucol on atheroma formation in cholesterol-fed rabbits kept at comparable plasma cholesterol levels
9. Vitamin E, antioxidants and lipid peroxidation in experimental atherosclerosis of rabbits
10. Vitamin E in a rabbit model of endogenous hypercholesterolemia and atherosclerosis
11. Potentiation of atherosclerotic lesions in rabbits by a high dietary level of vitamin E
12. Prevention and regression of primate atherosclerosis by d-alpha tocopherol
13. Biochemical and pathological features of a modified strain of Watanabe heritable hyperlipidemic rabbits
14. Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes
15. A simple test for predisposition to LDL oxidation based on the fluorescence development during copper-catalyzed oxidative modification
16. Effects of probucol on lipid metabolism and secretion in long term cultures of adult rat hepatocytes
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23. Probucol treatment affects the cellular composition but not anti-oxidized low density lipoprotein immunoreactivity of plaques from Watanabe heritable hyperlipidemic rabbits
24. Inhibition of IL-1b expression in THP-1 cells by probucol and tocopherol