Monoclonal Antibody Administration: Current Clinical Pharmacokinetic Status and Future Trends

Clinical Pharmacokinetics

Volumn 23, Issue 2, 1992, Pages 85-89

  Henry, Richard ^a   Begent, John ^a   Pedley, Rosamund Barbara ^a,b  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CARCINOEMBRYONIC ANTIGEN; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; RADIOISOTOPE; TUMOR ANTIGEN;

ANIMAL MODEL; ANTIGEN ANTIBODY COMPLEX; ANTIGEN RECOGNITION; BONE MARROW SUPPRESSION; CANCER INHIBITION; DRUG EFFICACY; DRUG TARGETING; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIOIMMUNOTHERAPY; REVIEW; TUMOR LOCALIZATION;

ANIMAL; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEOPLASM; ANTINEOPLASTIC AGENTS; DRUG CARRIERS; HUMAN; IMMUNOTOXINS; MICE; NEOPLASMS; TISSUE DISTRIBUTION;

EID: 0026715943     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.2165/00003088-199223020-00001     Document Type: Article

References (21)

1. Hypoxic cell radiosensitizers for radiotherapy
2. Experimental therapy of murine lymphoma with I-131 labelled anti-Thy 1.1 monoclonal antibody
3. Antibody-directed enzyme/prodrug therapy (ADEPT)
4. Antibody targeted therapy in cancer: comparison of murine and clinical studies
5. Chimeric B72.3 antibody for repeated radioimmunotherapy of colorectal carcinoma
6. Antibody distribution and dosimetry in patients receiving radiolabelled therapy for colorectal cancer
7. High dose radiolabeled antibody therapy of lymphoma
8. Ablation of human colon carcinoma in nude mice by 131I-labelled monoclonal anti-carcinoembryonic antigen antibody F(ab’)2 fragments
9. Experimental therapy of human breast tumours with 131I-labeled monoclonal antibodies prepared against the human milk fat globule
10. Complete tumour ablation with iodine 131I-radiolabeled disialoganglioside GD2-specific monoclonal antibody against human neuroblastoma xenografted in nude mice
11. In vivo tumor targeting of a recombinant single-chain antigen-binding protein
12. 131I distribution by gamma camera imaging
13. Nonuniformity of tumor dose in radioimmunotherapy
14. A pilot study of 131I monoclonal antibodies in the therapy of leptomeningeal tumors
15. In vivo localisation of radiolabeled antibodies to carcinoembryonic antigen in human colon carcinoma grafted into nude mice
16. The effect of circulating CEA on the distribution and clearance of anti-CEA antibody in a pancreatic tumour xenograft model
17. Preliminary observations on the microdistribution of labelled antibodies in human colonic adenocarcinoma xenografts: relevance to microdosimetry
18. 131I anti-CEA antibody in a colonic xenograft model
19. The effect of radiosensitizers on radioimmunotherapy, using 131I-labelled anti-CEA antibodies in a human colonic xenograft model
20. The effect of second antibody clearance on the distribution and dosimetry of radiolabelled anti-CEA antibody in a human co-Ionic tumor xenograft model
21. The use of paired labelling in the determination of tumour-localising antibodies