Basal- and insulin-stimulated substrate metabolism in patients with active acromegaly before and after adenomectomy

Journal of Clinical Endocrinology and Metabolism

Volumn 74, Issue 5, 1992, Pages 1012-1019

  Møller, Niels ^a   Schmitz, Ole ^a   Jørgensen, Jens O L ^a   Astrup, Jens ^a   Bak, Jens F ^a   Christensen, Stig E ^a   Alberti, K George M M ^b   Weeke, JøRgen ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUCOSE; GROWTH HORMONE; INSULIN; LACTIC ACID;

ACROMEGALY; ADULT; ARTICLE; BASAL METABOLIC RATE; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY EXPENDITURE; FEMALE; FOREARM; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT SYSTEM; GROWTH HORMONE BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; HYPOPHYSECTOMY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LACTATE BLOOD LEVEL; LIPID METABOLISM; LIPID OXIDATION; MALE; PRIORITY JOURNAL; TURNOVER TIME;

ACROMEGALY; ADULT; BASAL METABOLISM; FEMALE; GLUCOSE; GROWTH HORMONE; HORMONES; HUMAN; INSULIN; LIPIDS; MALE; MIDDLE AGE; PITUITARY GLAND; PULMONARY GAS EXCHANGE; SUPPORT, NON-U.S. GOV'T;

EID: 0026715813     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jcem.74.5.1569148     Document Type: Article

References (34)

1. Ikkos D, Ljunggren H, Luft R. Basal metabolic rate in relation to body size and cell mass in acromegaly. Acta Endocrinol. 1956;21:237-44.
2. Karlander S, Vranic M, Efendic S. Increased glucose turnover and glucose cycling in acromegalic patients with normal glucose tolerance. Diabetologia. 1986;29:778-83.
3. Hansen I, Tsalikian E, Beaufrere B, Gerich J, Haymond M, Rizza R. Insulin resistance in acromegaly: Defects in both hepatic and extrahepatic insulin action. Am J Physiol. 1986;250:E269-73.
4. Mimic D, Popovic V, Nesovic M, et al. A study of beta cell sensitivity to glucose and tissue sensitivity to insulin using the hyperglycemic and euglycemic clamp techniques in patients with active acromegaly. Diab Croat. 1986;15:15-22.
5. Reaven GM. Banting Lecture 1988: Role of insulin resistance in human disease. Diabetes. 1988;37:1595-607.
6. Stout RW. Insulin and atheroma. 20 yr perspective. Diabetes Care. 1990;13:631-54.
7. Wright AD, Hill DM, Lowy C, Fraser TR. Mortality in acromegaly. Quart J Med. 1970;153:1-16.
8. Alexander L, Appleton D, Hall R, Ross WM, Wilkinson R. Epidemiology of acromegaly in the Newcastle region. Clin Endocrinol. 1980;12:71-9.
9. Bengtsson B, Eden S, Ernest I, Oden A, Sjogren B. Epidemiology and long-term survival in acromegaly. Acta Med Scand. 1988-223-327-35
10. Moller N, Butler PC, Antsiferov MA, Alberti KGMM. Effects of growth hormone on insulin sensitivity and forearm metabolism in normal man. Diabetologia. 1989;32:105-10.
11. Lloyd B, Burrin J, Smythe P, Alberti KGMM. A simple automated flourimetric assay for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-hydroxubutyrate. Clin Chem. 1978;24:1724-9.
12. Ho RJ, Meng HC. A simple and ultrasensitive method for determination of free fatty acids by radichemical assay. Ann Biochem. 1969;31:426-30.
13. Orskov H, Thomsen HG, Yde H. Wick-chromatography for rapid and reliable immunoassay of insulin, glucagon and growth hormone. Nature, 1968;219:193-95.
14. Meller N, -Jorgensen JOL, Alberti KGMM, Flyvbjerg A, Schmitz O. Short-term effects of growth hormone on fuel oxidation and regional substrate metabolism in normal man. J Clin Endocrinol Metab. 1990;70:1179-86.
15. deBodo RC, Steele R, Altszuler N, Dunn A, Bishop JS. On the hormonal regulation of carbohydrate metabolism; studies with 014-glucose. Rec Prog Horm Res. 1963;19:445-88.
16. Frayn KN. Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol. 1983;55:628-34.
17. Whitney RJ. The measurement of volume changes in human limbs. J Physiol. 1953;121:1-27.
18. Schulman GI, Ladenson PW, Wolfe MH, Ridgway EC, Wolfe RR. Substrate cycling between gluconeogenesis and glycolysis in euthyroid, hypothyroid and hyperthyroid man. J Clin Invest. 1985;76:757-64.
19. Wolfe RR, Herndon DN, Jahoor F, Miyoshi H, Wolfe M. Effect of severe burn injury on substrate cycling by glucose and fatty acids. N Engl J Med. 1987;317:403-8.
20. Zierler KL, Rabinowitz D. Roles of insulin and growth hormone based on studies of forearm metabolism in man. Medicine. 1963;42:385-402.
21. Nikkila EA, Pelkonen R. Serum lipids in acromegaly. Metabolism. 1975;24:829-38.
22. DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP. The effect of insulin on the disposal of intravenous glucose. Diabetes. 1981;30:1000-7.
23. Malier N, Jargensen JOL, Schmitz O, et al. Effects of a growth hormone pulse on total and forearm substrate fluxes in humans. Am J Physiol. 1990;258:E86-E91.
24. Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1963;i:785-89.
25. Ferranninni E, Barrett EJ, Bevilacqua S, DeFronzo RA. Effect of Fatty acids on glucose production and utilization in man. J Clin Invest. 1983;72:1737-47.
26. Rizza R, Mandarino LW, Gerich JE. Effects of growth hormone on insulin action in man. Diabetes. 1982;31:663-9.
27. Bratusch-Marrain P, Smith D, DeFronzo RA. The effect of growth hormone on glucose metabolism and insulin secretion in man. J Clin Endocrinol Metab. 1982;55:973-82.
28. Bak JF, Maller N, Schmitz O. Effects of growth hormone on fuel utilization and muscle glycogen synthase activity in normal man. Am J Physiol. 1991;260:E736-42.
29. DeFronzo RA. The triumvirate: β-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes. 1988;37:667-87.
30. Chen Y.-DI, Golay A, Swislocki ALM, Reaven GM. Resistance to insulin suppression of plasma free fatty acid concentrations and insulin stimulation of glucose uptake in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1987;64:17-21.
31. Bogardus C, Taskinen MR, Zawadzki J, Lillioja S, Mott D, Howard B. Increased resting metabolic rates in obese subjects with noninsulin-dependent diabetes mellitus and the effect of sulfonyl urea therapy. Diabetes. 1986;35:1-5.
32. Roelfsema F, Frölich M. Glucose tolerance and plasma immuno-reactive insulin levels in acromegalics before and after selective transsphenoidal surgery. Clin Endocrinol. 1985;22:531-7.
33. Nabarro JDN. Acromegaly. Clin Endocrinol. 1987;26:481-512.
34. Ferranninni E, Buzzigoli G, Bonadonna R, et al. Insulin resistance in essential hypertension. N Engl J Med. 1987;317:350-7.