The presence of interleukln 4 during in vitro priming determines the lymphoklne-producing potential of CD4+ T cells from T cell receptor transgenic mice

Journal of Experimental Medicine

Volumn 176, Issue 4, 1992, Pages 1091-1098

  Seder, Robert A ^a   Paul, William E ^a   Davis, Mark M ^a,b   Fazekas de St Groth, Barbara ^a,b,c  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOCHROME C; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; LYMPHOKINE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE ACTIVATION; DENDRITIC CELL; FEMALE; FIBROBLAST; GENETIC TRANSFECTION; HUMAN; IMMUNOSTIMULATION; INTERFERON PRODUCTION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMAL; ANTIGENS, CD4; CELLS, CULTURED; CYTOCHROME C; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PIGEONS; RECEPTORS, ANTIGEN, T-CELL; SPLEEN; T-LYMPHOCYTE SUBSETS;

EID: 0026712313     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.176.4.1091     Document Type: Article

References (46)

1. Heinzel, F.P., M.D. Sadick, B.J. Holaday, R.L. Coffman, and R.M. Locksley. 1989. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J. Exp Med. 169:59.
2. Scott, P., P. Natovitz, R.L. Coffman, E. Pearce, and A. Sher. 1988. Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J. Exp Med. 168:1675.
3. Pearce, E.J., P. Caspar, J.M. Grzych, F.A. Lewis, and A. Sher. 1991. Downregulation of Thl cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J. Exp Med. 173:159.
4. Salgame, P., J.S. Abrams, C. Clayberger, H. Goldstein, J. Convit, R.L. Modlin, and B.R. Bloom. 1991. Differing lym-phokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science (Wash. DC). 254:279.
5. LeGros, G., S.Z. Ben-Sasson, R. Seder, F.D. Finkelman, and W.E. Paul. 1990. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp Med. 172:921.
6. Swain, S.L., A.D. Weinberg, M. English, and G. Huston. 1990. IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145:3796.
7. Betz, M., and B.S. Fox. 1990. Regulation and development of cytochrome c-specific IL-4-producing T cells. J. Immunol. 145:1046.
8. Sadick, M.D., F.P. Heinzel, B.J. Holaday, R.T. Pu, R.S. Dawkins, and R.M. Locksley. 1990. Cure of murine Leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon 7-independent mechanism. J. Exp Med. 171:115.
9. Chatelain, R., K. Varkila, and R.L. Coffman. 1992. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148:1182.
10. Hogan, B., F. Constantini, and E. Lacy. 1986. Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
11. Fink, P.J., L.A. Matis, D.L. McElligott, M. Bookman, and S.M. Hedrick. 1986. Correlations between T-cell specificity and the structure of the antigen receptor. Nature (Lond.). 321:219.
12. Unkeless, J.C. 1979. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J. Exp Med. 150:580.
13. Marshak-Rothstein, A., P. Fink, T. Gridley, D.H. Raulet, M.J. Bevan, and M.L. Gefter. 1979. Properties and applications of monoclonal antibodies directed against determinants of the Thy-1 locus. J. Immunol. 122:2491.
14. Dialynas, D.P., Z.S. Quan, K.A. Wall, A. Pierres, J. Quintan, M.R. Loken, M. Pierres, and F. Fitch. 1983. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule. J. Immunol. 131:2445.
15. Sarminento, M., A.L. Glasebrook, and F.W. Fitch. 1980. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement. J. Immunol. 125:2665.
16. Coffman, R.L. 1982. Surface antigen expression and immunoglobulin gene rearrangement during mouse Pre B cell development. Immunol. Rev. 69:5.
17. Oi, V., P.P. Jones, J.W. Goding, L.A. Herzenberg, and L.A. Herzenberg. 1978. Properties of monoclonal antibodies to mouse Ig antigen, He2 and la antigens. Curr. Top. Microbiol. Immunol. 81:115.
18. Curry, R.C., P.A. Keiner, and G.L. Spitalny. 1987. A sensitive immunochemical assay for biologically active Mu IFN-7.J. Immunol. Methods. 104:137.
19. Mosmann, T.R, and T.A.T. Fong. 1989. Specific assays for cytokine production by T cells. J. Immunol. Methods. 116:151.
20. Hu-Li, J., J. Ohara, C. Watson, W. Tsang, and W.E. Paul. 1989. Derivation of a T cell line that is highly responsive to IL4 and IL2 (CT.4R) and of an IL2 hyporesponsive mutant of that line (CT.4S). J. Immunol. 142:800.
21. Gillis, S., M.M. Ferm, W. Ou, and K.A. Smith. 1978. T cell growth factor: parameters of production and a quantitative microassay for activity. J. Immunol. 120:2027.
22. Ohara, J., and W.E. Paul. 1985. B cell stimulatory factor (BSF-1): production of a monoclonal antibody and molecular characterization. Nature (Lond.). 315:333.
23. Cherwinski, H., J. Schumacher, K. Brown, and T. Mosmann. 1987. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Thl and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J. Exp Med. 166:1229.
24. Budd, R., J. Cerottini, C. Horvath, C. Bron, T. Pedrazzini, R. Howe, and R. MacDonald. 1987. Distinction of virgin and memory T lymphocytes. J. Immunol. 138:3120.
25. Fink, P., W. Gallatin, R. Reichert, E. Butcher, and I. Weissman. 1985. Homing receptor-bearing thymocytes, an immunocompetent cortical subpopulation. Nature (Lond.). 313:233.
26. Crowley, M., K. Inaba, M. Witmer-Peck, and R.M. Steinman. 1989. The cell surface of mouse dendritic cells: FACS analysis of dendritic cells from different tissues including thymus. Cell. Immunol. 118:108.
27. Mosmann, T.R., J.H. Schumacher, D.F. Fiorentino, J. Leverah, K.W. Moore, and M.W. Bond. 1990. Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay. J. Immunol. 145:2938.
28. Seder, R.A., G. LeGros, S.Z. Ben-Sasson, J. Urban Jr., F.D. Finkelman, and W.E. Paul. 1991. Increased frequency of interleukin 4-producing T cells as a result of polyclonal priming. Use of a single-cell assay to detect interleukin 4-producing cells. Eur. J. Immunol. 21:1241.
29. Fiorentino, D.F., A. Zlotnik, P. Vieira, T.R. Mosmann, M. Howard, K.W. Moore, and A. O’Garra. 1991. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Thl cells. J. Immunol. 146:3444.
30. Gajewski, T.F., J. Joyce, and F.W. Fitch. 1989. Antigen-proliferative effect of IFN-7 in immune regulation. III. Differential selection of Thl and Th2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-7. J. Immunol. 143:15.
31. Powers, G.D., A.K. Abbas, and R.A. Miller. 1988. Frequencies of IL-2 and IL-4-secreting T cells in naive and antigen-stimulated lymphokine populations. J. Immunol. 140:3352.
32. + T cell subsets. Lymphocyte secretion of memory cells and of effector cells that develop from precursors in vitro.J. Immunol. 144:1788.
33. Pure, E., K. Inaba, and J. Metlay. 1988. Lymphokine production by murine T cells in the mixed leukocyte reaction. J. Exp Med. 168:795-800.
34. Metlay, J.P., E. Pure, and R.M. Steinman. 1989. Distinct features of dendritic cells and anti-Ig activated B cells as stimulators of the primary mixed leukocyte reaction. J. Exp Med. 169:239-254.
35. Swain, S.L., G. Huston, S. Tonkonogy, and A. Weinberg. 1991. Transforming growth factor-β and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype. J. Immunol. 147:2991.
36. Pfeiffer, C., J. Murray, J. Madri, and K. Bottomly. 1991. Selective activation of Thl- and Th2-like cells in vivo: response to human collagen IV. Immunol. Rev. 123:66.
37. Bretscher, P.A. 1983. In vitro analysis of the cellular interactions between unprimed lymphocytes responsible for determining the class of response an antigen induces: specific T cells switch a cell-mediated response to a humoral response. J. Immunol. 131:1103.
38. Ohara, J., and W.E. Paul. 1987. Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage. Nature (Lond.). 325:537.
39. Fiorentino, D.F., M.W. Bond, and T.R. Mosmann. 1989. Two types of mouse helper T cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Thl clones. J. Exp Med. 170:2081.
40. Bendelac, A., P. Matzinger, R.A. Seder, W.E. Paul, and R.H. Schwartz. 1992. Activation events during thymic selection.J. Exp Med. 175:731.
41. Ben-Sasson, S.Z., G. LeGros, D.H. Conrad, F.D. Finkelman, and W.E. Paul. 1990. Cross-linking Fc receptors stimulate splenic non-B, non-T cells to secrete interleukin 4 and other lymphokines. Proc Natl. Acad. Sci. USA. 87:1421.
42. Seder, R.A., W.E. Paul, A.M. Dvorak, S.J. Sharkis, A. Kagey-Sobotka, Y. Niv, F.D. Finkelman, S.A. Barbieri, S.J. Galli, and M. Plaut. 1991. Mouse splenic and bone marrow cell populations that express high-affinity Fee receptors and produce interleukin 4 are highly enriched in basophils. Proc. Natl. Acad. Sci. USA. 88:2835.
43. + bone marrow and splenic non-B, non-T cells are highly enriched in the capacity to produce IL-4 in response to immobilized IgE, IgG2a, or ionomycin. J. Immunol. 147:903.
44. Gajewski, T.F., M. Pinnas, T. Wong, and F.W. Fitch. 1991. Murine Thl and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations. J. Immunol. 146:1750.
45. Chang, T.-L., C.M. Shea, S. Urioste, R.C. Thompson, W.H. Boom, and A.K. Abbas. 1990. Heterogeneity of helper/inducer T lymphocytes. III. Responses of IL-2- and IL-4-producing (Thl and Th2) clones to antigens presented by different accessory cells. J. Immunol. 145:2803.
46. Koide, S., and R.M. Steinman. 1987. Induction of murine interleukin 1: stimuli and responsive primary cells. Proc. Natl. Acad. Sci. USA. 84:3802.