Losartan inhibits the angiotensin II-induced stimulation of the phosphoinositide signalling system in vascular smooth muscle cells

European Journal of Pharmacology: Molecular Pharmacology

Volumn 227, Issue 2, 1992, Pages 215-219

  Ko, Yon ^a   Görg, Anette ^a   Appenheimer, Marianne ^a   Wieczorek, Andreas J ^a   Düsing, Rainer ^a   Vetter, Hans ^a   Sachinidis, Agapios ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

Hypertrophy; Losartan; Phosphoinositide signalling system; Smooth muscle cells

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN ANTAGONIST; ARGIPRESSIN; CALCIUM; INOSITOL 1,4,5 TRISPHOSPHATE; LOSARTAN; LOSARTAN POTASSIUM; PLATELET DERIVED GROWTH FACTOR;

ANIMAL CELL; AORTA; ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; HYPERTROPHY; ION EXCHANGE; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANGIOTENSIN II; ANIMAL; AORTA; BIPHENYL COMPOUNDS; CALCIUM; CELL DIVISION; CELLS, CULTURED; IMIDAZOLES; INOSITOL 1,4,5-TRISPHOSPHATE; LOSARTAN; MUSCLE, SMOOTH, VASCULAR; RATS; RATS, INBRED WKY; SIGNAL TRANSDUCTION; TETRAZOLES;

EID: 0026709601     PISSN: 09224106     EISSN: None     Source Type: Journal    
DOI: 10.1016/0922-4106(92)90130-N     Document Type: Article

References (17)

1. Early agonist-mediated ionic events in cultured vascular smooth muscle cells
2. Changes in the levels of inositol phosphates after agonists-dependent hydrolysis of membrane phosphoinositides
3. A rapid and sensitive method for the quantification of microgram quantities of protein utilising the principle of protein-dye binding
4. In vitro effects of DuP 753, a nonpeptide angiotensin II receptor antagonist on human platelets and rat vascular smooth muscle cells
5. Effects of angiotensin II and vasopressin on human smooth muscle cells in vitro
6. Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent
7. Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells
8. 2+ indicators with greatly improved fluorescence properties
9. Pharmacologic interruption of the renin-angiotensin system
10. Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands
11. Stimulation of aortic smooth muscle cell mitogenesis by serotonin
12. Calcium messenger system, an integrated view
13. The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibre
14. The renin-angiotensin system
15. 2+ and pH. Putative signals for the control of cell growth
16. Preliminary biochemical characterisation of two angiotensin II receptor subtypes in the rat
17. Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP 753, an orally active antihypertensive agent