Inhibition of endotoxin-mediated activation of endothelial cells by a perfluorocarbon emulsion

Biomaterials, Artificial Cells and Immobilization Biotechnology

Volumn 20, Issue 4 --Feb, 1992, Pages 1051-1057

  Lane, T ^a   Smith, P ^a   Wancewicz, E ^a   Funk, R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN-ANTIBODY REACTIONS; BIOCOMPATIBILITY; CELL CULTURE; EMULSIONS; FLUOROCARBONS; METABOLISM; TOXICITY;

E. COLI ENDOTOXIN; ENDOTHELIAL CELL ACTIVATION; ENDOTOXIN-MEDIATED INFLAMMATORY RESPONSE; FLUOROCARBON-BASED BLOOD SUBSTITUTES; INFLAMMATORY IMMUNE REACTIONS; INTERLEUKIN-1; LEUKOCYTE ADHESION; PERFLUOROCARBON EMULSIONS; PERFLUOROOCTYLBROMIDE EMULSIONS; TUMOR NECROSIS FACTOR;

BLOOD SUBSTITUTES;

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ESCHERICHIA COLI ENDOTOXIN; FLUOROCARBON; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; TUMOR NECROSIS FACTOR ALPHA;

CELL FUNCTION; CONFERENCE PAPER; DOSE RESPONSE; DRUG ACTIVITY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION;

BLOOD SUBSTITUTES; CELL ADHESION MOLECULES; CELLS, CULTURED; E-SELECTIN; EMULSIONS; ENDOTHELIUM, VASCULAR; ENDOTOXINS; FLUOROCARBONS; HUMAN; INTERCELLULAR ADHESION MOLECULE-1; LIPOPOLYSACCHARIDES; UP-REGULATION;

EID: 0026709550     PISSN: 10557172     EISSN: None     Source Type: Journal    
DOI: 10.3109/10731199209119762     Document Type: Article

References (3)

1. Lane T. A. Lamkin G. E. and Wancewicz E. Protein Kinase C Inhibitors Block The Enhanced Expression Ol’ Intercellular Adhesion Molecule 1 On Endothelial Cells Activated By Interleukin 1, Lipopolysaccharide And Tumor Necrosis Factor. Biochemical and Biophvsical Research Communications. 172:1273-1281. 1990.
2. May H. Cohen J Studies on the specificity of the L929 cell bioassay for the measurement of tumour necrosis factor. J Clin Lab Immunol. 29:151-5. 1989.
3. Ziegler E. J. Fisher C. J. Jr, Sprung C. L. Straube R. C. Sadoff J. C. Foulke G. E. Wortel C. H. Fink M. P. Dellinger R. P. Teng N. N. et al. Treatment of gramnegative bacteremia and septic shock with IIA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group. N Engl J Med, 324:429-36, 19