The effects of plasma estradiol levels on increases in vertebral and femoral bone density following therapy with estradiol and estradiol with testosterone implants

Obstetrics and Gynecology

Volumn 79, Issue 6, 1992, Pages 968-972

  Garnett, Timothy ^a,b   Studd, John ^a,b   Watson, Neale ^a,b   Savvas, Michael ^a,b   Leather, Andrew ^a,b  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

^b LISTER HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; NORETHISTERONE ACETATE; TESTOSTERONE;

ARTICLE; BONE DENSITY; CONTROLLED STUDY; FEMALE; HORMONE DEFICIENCY; HORMONE SUBSTITUTION; HUMAN; MAJOR CLINICAL STUDY; MENOPAUSE; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

BONE DENSITY; DRUG IMPLANTS; DRUG THERAPY, COMBINATION; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; FEMALE; FEMUR; HUMAN; LUMBAR VERTEBRAE; MENOPAUSE; MIDDLE AGE; SUPPORT, NON-U.S. GOV'T; TESTOSTERONE;

EID: 0026708615     PISSN: 00297844     EISSN: 1873233X     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Lindsay R, Hart DM, Aitken JM, MacDonald EB, Anderson JB, Clark AC. Long-term prevention of postmenopausal osteoporosis by oestrogen. Lancet 1976;1:1038-9.
2. Nachtigall LE, Nachtigall H, Nachtigall RD, Beckman ME. Estrogen replacement therapy. 1: A 10-year prospective study of the relationship to osteoporosis. Obstet Gynecol 1979;53:277-81.
3. Christiansen C, Christensen S, McNair P, Hagen C. Prevention of early postmenopausal bone loss: Controlled 2-year study in 315 normal females. Eur J Clin Invest 1980;10:273-9.
4. Ettinger B, Genant HK, Cann CE. Post-menopausal bone loss is prevented by treatment with low-dosage estrogen with calcium. Ann Intern Med 1987;106:40-5.
5. Munk-Jensen N, Nielsen SP, Obel EB, Eriksen PB. Reversal of postmenopausal vertebral bone loss by oestrogen and progestogen: A double-blind placebo controlled study. Br Med J 1988;296: 1150-2.
6. Stevenson JC, Cust MP, Ganger KF, Hillard TC, Lees B, White- head ML Effects of transdermal versus oral hormone replacement therapy on bone density in spine and proximal femur in postmenopausal women. Lancet 1990;336:265-9.
7. Studd JWW, Magos AL. Hormone pellet implantation for the menopause and premenstrual syndrome. Obstet Gynecol Clin North Am 1987;14:229-49.
8. Savvas M, Studd JWW, Fogelman I, Dooley M, Montgomery J, Murby B. Skeletal effects of oral oestrogen compared with subcutaneous oestrogen and testosterone in post-menopausal women. Br Med J 1988;297:331-3.
9. Thom M, Studd JWW. Practical procedures: Hormone implantation. Br Med J 1980;280:648-50.
10. Sturdee D, Wade-Evans T, Paterson MEL, Thom M, Studd JWW. Relations between bleeding pattern, endometrial histology and oestrogen treatment in menopausal women. Br Med J 1978;1: 1575-7.
11. Lindsay R, Hart DM, Clark DM. The minimum effective dose of estrogen for prevention of post-menopausal bone loss. Obstet Gynecol 1984;63:759-63.
12. Civitelli R, Agnusdei D, Nardi P, Zacchei F, Avioli LV, Gennari C. Effects of one-year treatment with estrogens on bone mass, intestinal calcium absorption, and 25-hydroxyvitamin D-1cxhydroxylase reserve in postmenopausal osteoporosis. Calcif Tissue Int 1988;42:77-86.
13. Adami S, Suppi R, Bertoldo F, et al. Transdermal estradiol in the treatment of postmenopausal bone loss. Bone Miner 1989;7:79-86.
14. Riis BJ, Thomsen K, Stom V, Christiansen C. The effect of percutaneous estradiol and natural progesterone on postmenopausal bone loss. Am J Obstet Gynecol 1987;156:61-5.
15. Parfitt AM, Mathews CHE, Villanueva AR, Kleerekoper B, Rao DS. Relationships between surface, volume and thickness of iliac trabecular bone in aging and in osteoporosis. J Clin Invest 1983;72:1396-409.
16. Ernst M, Heath JK, Rodan G. Estradiol effects on proliferative messenger ribonucleic acid for collagen and insulin-like growth factor I, and parathyroid hormone-stimulated adenylate cyclase activity in osteoblastic cells for calvariae and long bones. Endocrinology 1989;125:825-33.
17. Brincat M, Versi E, Moniz CF, Magos A, deTrafford J, Studd JWW. Skin collagen changes in postmenopausal women receiving different regimens of estrogen therapy. Obstet Gynecol 1987;70:123-7.
18. Montgomery JC, Appleby L, Brincat M, Studd JWW. Sexual dysfunction in climacteric women: Treatment with implanted estradiol alone and in combination with testosterone. Maturitas (in press).
19. Montgomery JC, Appleby L, Brincat M, et al. Effect of estrogen and testosterone implants on psychological disorders in the climacteric. Lancet 1987;1:297-9.
20. Brincat M, Magos AL, Studd JWW. Sub-cutaneous hormone implants for the control of climacteric symptoms: A prospective study. Lancet 1984;1:16-8.
21. Stevenson JC, Lees B, Devenport M, Cust MP, Ganger KF. Determinants of bone density in normal women: Risk factors for future osteoporosis? Br Med J 1989;298:924-8.
22. Hedlund LR, Galagher JC. The effect of age and menopause on bone mineral density of the proximal femur. J Bone Miner Res 1989;4:639-42.
23. Melton LJ, Wahner HW, Richelson LS, O’Fallon WM, Riggs BL. Osteoporosis and the risk of hip fracture. Am J Epidemiol 1986;124:254-61.
24. Hutchinson TA, Polansky SM, Feinstein A. Postmenopausal oestrogens protect against fractures of hip and distal radius. Lancet 1979;2:706-9.
25. Weiss NS, Ure CL, Ballard JH, Williams AR, Daling JR. Decreased risk of fractures of the hip and lower forearm with postmenopausal use of estrogen. N Engl J Med 1980;303:1095-8.
26. Al-Azzawi F, Hart DM, Lindsay R. Long term effect of oestrogen replacement therapy on bone mass as measured by dual photon absorptiometry. Br Med J 1987;298:924-8.
27. Garnett T, Studd JWW, Henderson AF, Watson NR, Savvas M, Leather A. Hormone implants and tachyphylaxis. Br J Obstet Gynaecol 1990;97:917-21.