Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant n,n′-diphenyl-phenylenediamine

Journal of Clinical Investigation

Volumn 89, Issue 6, 1992, Pages 1885-1891

  Sparrow, Carl P ^a   Doebber, Thomas W ^a   Olszewski, Joanne ^a   Wu, Margaret S ^a   Ventre, John ^a   Stevens, Karla A ^a   Chao, Yu Sheng ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Arteriosclerosis; Cholesterol; Macrophage; Probucol; Scavenger receptors

Indexed keywords

BUTYLCRESOL; COPPER SULFATE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN; N,N' DIPHENYL 1,4 PHENYLENEDIAMINE; PROBUCOL;

ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; LIPOPROTEIN METABOLISM; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RABBIT; STRUCTURE ACTIVITY RELATION; TRIACYLGLYCEROL BLOOD LEVEL;

ADMINISTRATION, ORAL; ANIMAL; ANTIOXIDANTS; ARTERIOSCLEROSIS; CHOLESTEROL; HUMAN; KINETICS; LIPOPROTEINS, LDL; MALE; OXIDATION-REDUCTION; PHENYLENEDIAMINES; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0026708232     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI115793     Document Type: Article

References (17)

1. Gown, A. M., T. Tsukada, and R. Ross. 1986. Human Atherosclerosis: II Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions. Am. J. Pathol. 125:191-207.
2. Gerrity, R. G. 1981. The role of the monocyte in atherogenesis. I. Transition of blood-borne monocytes into foam cells in fatty lesions. Am. J. Pathol. 103:181-190.
3. Zemel, P. C. and J. R. Sowers. 1990. Relation between lipids and atherosclerosis: epidemiologic evidence and clinical implications. Am. J. Cardiol. 66:71-121.
4. Heiss, G., N. Johnson, S. Reiland, C. E. Davis, and H. E. Tyroler. 1980. The epidemiology of plasma high-density lipoprotein cholesterol levels: the lipid research clinics program prevalence study. Circulation. 62 (Suppl. IV):116-136.
5. Glomset, J. A. 1968. The plasma lecithin:cholesterol acyltransferase reaction. J. Lipid Res. 9:155-167.
6. Steinberg, D., S. Parthasarathy, T. E. Carew, J. C. Khoo, and J. L. Witztum. 1989. Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. N. Engl. J. Med. 320:915-924.
7. Steinbrecher, U. P., S. Parthasarathy, D. S. Leake, J. L. Witztum, and D. Steinberg. 1984. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc. Natl. Acad. Sci. USA. 81:3883-3887.
8. Cathcart, M. K., D. W. Morel, and G. M. Chisolm. 1985. Monocytes and neutrophihs oxidize low density lipoprotein making it cytotoxic. J. Leukocyte Biol. 38:341-350.
9. Parthasarathy, S., D. J. Printz, D. Boyd, L. Joy, and D. Steinberg. 1986. Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor. Arteriosclerosis. 6:505-510.
10. Sparrow, C. P., S. Parthasarathy, and D. Steinberg. 1989. A macrophage receptor that recognizes oxidized low density lipoprotein but not acetylated low density lipoprotein. J. Biol. Chem. 264:2599-2604.
11. Brown, M. S., and J. L. Goldstein. 1983. Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis. Annu. Review Biochem. 52:223-261.
12. Quinn, M. T., S. Parthasarathy, L. G. Fong, and D. Steinberg. 1987. Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis. Proc. Natl. Acad. Sci. USA. 84:2995-2998.
13. Rosenfeld, M. E., T. Tsukada, A. Chait, E. L. Bierman, A. M. Gown, and R. Ross. 1987. Fatty streak expansion and maturation in Watanabe heritable hyperlipemic and comparably hypercholesterolemic fat-fed rabbits. Arteriosclerosis. 7:24-34.
14. Cushing, S. D., J. A. Berliner, A. J. Valente, M. C. Territo, M. Navab, F. Parhami, R. Gerrity, C. J. Schwartz, and A. M. Fogelman. 1990. Minimally modified low density lipoprotein induces monocyte chemotactic protein I in human endothelial cells and smooth muscle cells. Proc. Natl. Acad. Sci. USA. 87:5134-5138.
15. Haberland, M. E., D. Fong, and L. Cheng. 1988. Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipemic rabbits. Science (Wash. DC). 241:215-218.
16. Rosenfeld, M. E., W. Palinski, S. Yla-Herttuala, S. Butler, and J. L. Witztum. 1990. Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits. Arteriosclerosis. 10:336-349.
17. O'Brien, K., Y. Nagano, A. Gown, T. Kita, and A. Chait. 1991. Probucol treatment affects the cellular composition but not anti-oxidized low density liprotein immunoreactivity of plaques from Watanabe heritable hyperlipidemic rabbits. Arterioscler. Thromb. 11:751-759.