Impairment of Renal Function with Increasing Blood Lead Concentrations in the General Population

New England Journal of Medicine

Volumn 327, Issue 3, 1992, Pages 151-156

  Staessen, Jan A ^a   Lauwerys, Robert R ^b   Buchet, Jean Pierre ^b   Bulpitt, Christopher J ^a   Rondia, Désiré ^c   Vanrenterghem, Yves ^d   Amery, Antoon ^a  

^a KU LEUVEN DEPARTMENT OF REHABILITATION SCIENCES   (Belgium)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c UNIVERSITY OF LIÈGE   (Belgium)

^d UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; CADMIUM; CREATININE; GAMMA GLUTAMYLTRANSFERASE; LEAD; PROTOPORPHYRIN ZINC;

ADULT; ARTICLE; BLOOD CHEMISTRY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; KIDNEY FUNCTION; LEAD BLOOD LEVEL; MALE; NORMAL HUMAN; PRIORITY JOURNAL; QUESTIONNAIRE;

EID: 0026704297     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199207163270303     Document Type: Article

References (29)

1. Bernard A, Lauwerys R. Cadmium in human population. Experientia 1984; 40: 143–52.
2. Wedeen RP, Maesaka JK, Weiner B, et al. Occupational lead nephropathy. Am J Med 1975; 59: 630–41.
3. Buchet J-P, Lauwerys R, Roels H, et al. Renal effects of cadmium body burden of the general population. Lancet 1990; 336: 699–702.
4. Staessen J, Yeoman WB, Fletcher AE, et al. Blood lead concentration, renal function, and blood pressure in London civil servants. Br J Ind Med 1990; 47: 442–7.
5. Lauwerys R, Amery A, Bernard A, et al. Health effects of environmental exposure to cadmium: objectives, design and organization of the Cadmibel Study: a cross-sectional morbidity study carried out in Belgium from 1985 to 1989. Environ Health Perspect 1990; 87: 283–9.
6. Staessen J, Bulpitt CJ, Fagard R, Joossens JV, Lijnen P, Amery A. Salt intake and blood pressure in the general population: a controlled intervention trial in two towns. J Hypertens 1988; 6: 965–73.
7. Karlsson FA, Wibell L, Evrin PE. β2-Microglobulin in clinical medicine. Scand J Clin Lab Invest Suppl 1980; 154: 27–37.
8. Bartels H, Böhmer M. Eine Mikromethode zur Kreatininbestimmung. Clin Chim Acta 1971; 32: 81–5.
9. Bernard AM, Lauwerys RR. Continuous-flow system for automation of latex immunoassay by particle counting. Clin Chem 1983; 29: 1007–11.
10. Persijn JP, van der Silk W. A new method for the determination of γ-glutamyltransferase in serum. J Clin Chem Clin Biochem 1976; 14: 421–7.
11. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16: 31–41.
12. Emmerson BT, Lecky DS. The lead content of bone in subjects without recognized past lead exposure and in patients with renal disease. Australas Ann Med 1963; 12: 139–42.
13. Campbell BC, Elliott HL, Meredith PA. Lead exposure and renal failure: does renal insufficiency influence lead kinetics? Toxicol Lett 1981; 9: 121–4.
14. Batuman V, Landy E, Maesaka JK, Wedeen RP. Contribution of lead to hypertension with renal impairment. N Engl J Med 1983; 309: 17–21.
15. Emmerson BT. Lead stores in patients with renal insufficiency. Nephron 1991; 58: 233–4.
16. Hilbrands LB, Artz MA, Wetzels JFM, Koene RAP. Cimetidine improves the reliability of creatinine as a marker of glomerular filtration. Kidney Int 1991; 40: 1171–6.
17. Staessen J, Sartor F, Roels H, et al. The association between blood pressure, calcium and other divalent cations: a population study. J Hum Hypertens 1991; 5: 485–94.
18. Chisolm JJ Jr. Aminoaciduria as a manifestation of renal tubular injury in lead intoxication and a comparison with patterns of aminoaciduria seen in other diseases. J Pediatr 1962; 60: 1–17.
19. Emmerson BT, Mirosch W. Douglas JB. The relative contributions of tubular reabsorption and secretion to urate excretion in lead nephropathy. Aust N Z J Med 1971; 1: 353–62.
20. Graziano JH, Slavkovic V, Factor-Litvak P, Popovac D, Ahmedi X, Mehmeti A. Depressed serum erythropoietin in pregnant women with elevated blood lead. Arch Environ Health 1991; 46: 347–50.
21. Cramer K, Goyer RA, Jagenburg R, Wilson MH. Renal ultrastructure, renal function, and parameters of lead toxicity in workers with different periods of lead exposure. Br J Ind Med 1974; 31: 113–27.
22. A review of the evidence relating to lead as an aetiological agent in chronic nephritis in Queensland. Med J Aust 1934; 1: 600–6.
23. Sharp DS, Becker CE, Smith AH. Chronic low-level lead exposure: its role in the pathogenesis of hypertension. Med Toxicol 1987; 2: 210–32.
24. Pocock SJ, Shaper AG, Ashby D, Delves T, Whitehead TP. Blood lead concentration, blood pressure, and renal function. BMJ 1984; 289: 872–4.
25. Buchet JP, Roels H, Bernard A, Lauwerys R. Assessment of renal function of workers exposed to inorganic lead, cadmium or mercury vapor. J Occup Med 1980; 22: 741–50.
26. Gerhardsson L, Chettle DR, Englyst V, et al. Kidney effects in long term exposed lead smelter workers. Br J Ind Med 1992; 49: 186–92.
27. Intersalt Cooperative Study Group. Intersalt: an international study of electrolyte excretion and blood pressure: results for 24 hour urinary sodium and potassium excretion. BMJ 1988; 297: 319–28.
28. Levey AS, Perrone RD, Madias NE. Serum creatinine and renal function. Annu Rev Med 1988; 39: 465–90.
29. World Health Organization Regional Office for Europe. Air quality guidelines for Europe. WHO regional publications, European series no. 23. Copenhagen, Denmark: World Health Organization, 1987:242–61.