Modulation by opioids and by afferent sensory neurones of prostanoid protection of the rat gastric mucosa

British Journal of Pharmacology

Volumn 106, Issue 4, 1992, Pages 846-852

  Esplugues, J V ^a   Whittle, B J R ^b   Moncada, S ^b  

^a UNIVERSITY OF VALENCIA   (Spain)

^b WELLCOME RESEARCH LABORATORIES   (United Kingdom)

Author keywords

16,16 dimethyl PGE2; capsaicin; gastric damage; morphine; mucosal protection; Opioids; prostaglandins; sensory neurones

Indexed keywords

16,16 DIMETHYLPROSTAGLANDIN E2; 17 METHYLNALORPHINE; ALCOHOL; AMINOPHYLLINE; CAPSAICIN; MORPHINE; NALOXONE; NEUROPEPTIDE; OPIATE; TERBUTALINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; HISTOLOGY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; STOMACH MUCOSA LESION; STOMACH PROTECTION;

ANIMAL; CAPSAICIN; DINOPROSTONE; ETHANOL; GASTRIC MUCOSA; MALE; MORPHINE; NALOXONE; NARCOTICS; NEURONS, AFFERENT; PROSTAGLANDINS; RATS; RATS, INBRED STRAINS;

EID: 0026703991     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1992.tb14423.x     Document Type: Article

References (51)

1. Modification by capsaicin and compound 48/80 of dye leakage induced by irritants in the rat
2. Opiate agonists inhibit neurogenic plasma extravasation in the rat
3. Comparison of the effects of histamine and prostaglandin on afferent C‐fiber endings and irritant receptors in the intrapulmonary airways
4. Stimulation of ‘irritant’ receptors and afferent C‐fibres in the lungs by prostaglandins
5. Peptide‐containing nerve fibres in the stomach wall of rat and mouse
6. Influence of capsaicin‐sensitive afferent neurones on the acid secretory responses of the rat stomach in vivo
7. Morphine potentiation of ethanol‐induced gastric mucosal damage in the rat
8. Peripheral opioid‐sensitive mechanisms of mucosal injury and protection
9. Local opioid‐sensitive afferent sensory neurones in the modulation of gastric damage induced by PAF.
10. II‐Prostaglandin hyperalgesia: the peripheral analgesic activity of morphine, enkephalines and opioid antagonists
11. Characterization of the peptidergic afferent innervation of the stomach in the rat, mouse and guinea‐pig
12. Histologic and microcirculatory changes in alcohol‐induced gastric lesions in the rat: effect of prostaglandin cytoprotection
13. Influence of vagotomy on mucosal protection against alcohol‐induced gastric damage in the rat
14. Local effector functions of capsaicin‐sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene‐related peptide and other neuropeptides
15. Capsaicin: Cellular targets, mechanism of action, and selectivity for thin sensory neurones
16. Neuropeptide control of rat gastric mucosal blood flow: increase by calcitonin gene‐related peptide and vasoactive intestinal polypeptide, but not substance P and neurokinin A.
17. Stimulation of afferent nerve endings by intragastric capsaicin protect against ethanol‐induced damage of gastric mucosa
18. Sensory neurones mediate protective vasodilatation in rat gastric mucosa
19. Afferent nerve‐mediated protection against deep mucosal damage in the rat stomach
20. Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin‐sensitive afferent neurones
21. Microscopic analysis of ethanol damage to the rat gastric mucosa after treatment with a prostaglandin
22. Opioid control of the function of primary afferent substance P fibres
23. Close arterial infusion of calcitonin gene‐relate peptide into the rat stomach inhibits aspirin‐ and ethanol‐induced hemorrhagic damage
24. Prostanoids modulate reflex micturition by acting through capsaicin‐sensitive afferents
25. Effects of opioid drugs on capsaicin‐sensitive neurones in guinea‐pig atria
26. Substance P and peripheral inflammatory hyperalgesia
27. A role of nitric oxide in capsaicin‐induced gastroprotection
28. 2 or sodium thiosulfate
29. Influence of morphine or capsaicin pretreatment on rat gastric microcirculatory response to PAF.
30. Endogenous nitric oxide as a mediator of gastric mucosal vasodilatation during acid secretion
31. The vasodilator role of endogenous nitric oxide in the rat gastric microcirculation
32. Capsaicin‐sensitive vagal afferent fibres and stimulation of gastric acid secretion in anaesthetized rats
33. Antisecretory, anti‐ulcer, cytoprotective and diarrhoegenic properties of prostaglandins
34. Prostaglandins and the gastrointestinal tract
35. Cytoprotection by prostaglandins in rats‐Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury
36. Morphine and met‐enkephalin effects on sural A afferent terminal excitability
37. Sensory substance P innervation of the stomach and pancreas. Demonstration of capsaicin‐sensitive sensory neurones in the rat by combined immunohistochemistry and retrograde tracing
38. Peripheral opioid receptors on rat saphenous nerve
39. Distribution and characterisation of calcitonin gene‐related peptide immunoreactivity in the digestive system of normal and capsaicin‐treated rats
40. Dual intrinsic and extrinsic origins of CGRP‐ and NPY‐immunoreative nerves of rat gut and pancreas
41. Impaired defense mechanism to peptic ulcer in the capsaicin‐desensitized rat
42. Endogenous nitric oxide and sensory neuropeptides interact in the modulation of the rat gastric microcirculation
43. Capsaicin‐sensitive afferent fibres contribute to gastric mucosal blood flow response to electrical vagal stimulation
44. Relationship between the prevention of rat gastric erosions and the inhibition of acid secretion by prostaglandins
45. The potentiation of taurocholate‐induced rat gastric erosions following parenteral administration of cyclooxygenase inhibitors
46. Role of endogenous nitric oxide in the mechanisms underlying gastric mucosal integrity
47. Interactions between the vascular peptide endothelin‐1 and sensory neuropeptides in gastric mucosal injury
48. Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat
49. Evaluation of the protection of rat gastric mucosa by a prostaglandin analogue using cellular enzyme marker and histologic techniques
50. Role of endogenous vasoactive mediators, nitric oxide, prostanoids and sensory neuropeptides in the regulation of gastric mucosal blood flow and mucosal integrity
51. Prostanoids as regulators of gastrointestinal function