Stereoisomers of Ketoconazole: Preparation and Biological Activity

Journal of Medicinal Chemistry

Volumn 35, Issue 15, 1992, Pages 2818-2825

  Rotstein, David M ^a   Kertesz, Denis J ^a   Walker, Keith A M ^a   Swinney, David C ^b  

^a Syntex Research Institute of Organic Chemistry   (United States)

^b Department of Drug Metabolism ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYTOCHROME P450; DRUG METABOLIZING ENZYME; KETOCONAZOLE; LYASE; OXYGENASE;

ANIMAL CELL; ARTICLE; BROMINATION; CHOLESTEROL SYNTHESIS; DRUG ACTIVITY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; LIVER MICROSOME METABOLISM; MALE; MICROSOME; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; STEREOISOMERISM; STEROIDOGENESIS; SWINE; XENOBIOTIC METABOLISM;

ADRENAL GLANDS; ANIMAL; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HUMAN; KETOCONAZOLE; MALE; MICROSOMES; MICROSOMES, LIVER; PLACENTA; PREGNANCY; RATS; STEREOISOMERISM; SWINE; TESTIS;

EID: 0026703849     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00093a015     Document Type: Article

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