U-73122, an aminosteroid phospholipase C antagonist, noncompetitively inhibits thyrotropin-releasing hormone effects in GH3 rat pituitary cells

Endocrinology

Volumn 131, Issue 4, 1992, Pages 1883-1888

  Smallridge, Robert C ^a   Kiang, Juliann G ^a   Gist, Irene D ^a   Fein, Henry G ^a   Galloway, Richard J ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 2,5 PYRROLIDINEDIONE; CALCIUM ION; NIFEDIPINE; PHOSPHOLIPASE C; PHOSPHOLIPASE INHIBITOR; PROLACTIN; PROTIRELIN; VERAPAMIL;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL STRAIN GH3; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ENZYME INHIBITION; HORMONE INHIBITION; HORMONE RELEASE; HYPOPHYSIS CELL; MICHAELIS CONSTANT; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; CALCIUM; CELL LINE; CYTOSOL; ESTRENES; INOSITOL PHOSPHATES; OSMOLAR CONCENTRATION; PHOSPHOLIPASE C; PITUITARY GLAND; PROLACTIN; PROTIRELIN; PYRROLIDINONES; RATS;

EID: 0026702863     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/endo.131.4.1396332     Document Type: Article

References (22)

1. 3 cells. J Biol Chem 258:14816-14822
2. 3 cells): direct evidence for the mobilization of cellular calcium. J Cell Biol99:83-87
3. 3 cells. Biochem Biophys Res Commun128:531-537
4. 2+. Endocrinology 116:591-596
5. Kolesnick RN, Gershengorn MC 1986 Thyrotropin-releasing hormone stimulation of prolactin secretion is coordinately but not synergistically regulated by an elevation of cytoplasmic calcium and 1,2-diacylglycerol. Endocrinology 119:2461-2466
6. 3). J Biol Chem 261:7223-7229
7. Gershengorn MC 1986 Mechanism of thyrotropin releasing hormone stimulation of pituitary hormone secretion. Annu Rev Physiol48:515-526
8. 1 rat pituitary cells. J Biol Chem 260:8366-8371
9. Kolesnick RN, Gershengorn MC 1985 Direct evidence that burst but not sustained secretion of prolactin stimulated by thyrotropinreleasing hormone is dependent on elevation of cytoplasmic calcium. J Biol Chem 260:5217-5220
10. 3 cells. J Biol Chem 265:7623-7631
11. 2+ signals evoked by activation of receptors linked to inositol lipid hydrolysis: mechanism of generation. J Membr Biol 118:93-105
12. Smith RJ, Sam LM, Justen JM, Bundy GL, Bala GA, Bleasdale JE1990 Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness. J Pharmacol Exp Ther253:688-697
13. Bleasdale JE, Thakur NR, Gremban RS, Bundy GL, Fitzpatrick FA, Smith RJ, Bunting S 1990 Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J Pharmacol Exp Ther255:756-768
14. Thompson AK, Mostafapour SP, Denlinger LC, Bleasdale JE, Fisher SK 1991 The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells. J Biol Chem 266:23856-23862
15. 2+-calmodulin dependent pathway. Clin Res 39:312A (Abstract)
16. Carr FE, Galloway RJ, Reid AH, Kaseem LL, Dhillon G, Fein HG, Smallridge RC 1991 Thyrotropin-releasing hormone regulation of thyrotropin β-subunit gene expression involves intracellular calcium and protein kinase C Biochemistry 30:3721-3728
17. Smallridge RC 1991 8-Diethylamino-octyl-3,4,5-trimethoxyben-zoate, a calcium store blocker, increases calcium influx, inhibits α-1 adrenergic receptor calcium mobilization, and alters iodide transport in FRTL-5 rat thyroid cells. Endocrinology 129:542-549
18. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450
19. Berridge MJ 1983 Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides rather than phosphatidylinositol. Biochem J 212:849-858
20. nd Annual Meeting of the Endocrine Society, Atlanta, GA, 1990 p 261 (Abstract 948)
21. Stryer L 1975 Biochemistry. WH Freeman, San Francisco, pp 124-133
22. 2+ accumulation, storage, and release. J Biol Chem 266:20159-20167