Antigenic variation and strain heterogeneity in Borrelia spp.

Research in Microbiology

Volumn 143, Issue 6, 1992, Pages 583-596

  Wilske, B ^a   Barbour, A G ^b   Bergström, S ^c   Burman, N ^c   Restrepo, B I ^b   Rosa, P A ^d   Schwan, T ^d   Soutschek, E ^e   Wallich, R ^f  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF TEXAS   (United States)

^c UMEÅ UNIVERSITY   (Sweden)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e MIKROGEN GMBH   (Germany)

^f GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Antigenic variation and heterogeneity; Antig nicite, Borrelia; Borrelia, Antigenicity; Recombinant proteins, Vaccination; Variation et h t rog n it antig nique, Vaccination, Prot ines recombinantes

Indexed keywords

BACTERIAL ANTIGEN;

BACTERIUM; BORRELIA; CONFERENCE PAPER; NONHUMAN; PRIORITY JOURNAL; PROTEIN POLYMORPHISM;

ANTIGENIC VARIATION; BACTERIAL OUTER MEMBRANE PROTEINS; BORRELIA BURGDORFERI GROUP; FLAGELLIN; IN VITRO; RECOMBINATION, GENETIC; SEROTYPING;

EID: 0026701683     PISSN: 09232508     EISSN: 17697123     Source Type: Journal    
DOI: 10.1016/0923-2508(92)90116-6     Document Type: Article

References (61)

1. Phenotypic and genotypic analysis of Borrelia burgdorferi isolates from various sources
2. Antibodies of patients with Lyme disease to components of the Ixodes dammini spirochete
3. Structural analysis of the variable major proteins of Borrelia hermsii
4. Variable antigen genes of the relapsing fever agent Borrelia hermsii are activated by promoter addition
5. Tandem insertion sequence-like elements define the expression site for variable antigen genes of Borrelia hermsii
6. Linear plasmids of the bacterium Borrelia burgdorferi have covalently closed ends
7. Heterogeneity of major proteins in Lyme disease Borreliae: a molecular analysis of North American and European isolates
8. Polymorphisms of major surface proteins of Borrelia burgdorferi
9. Variation in a major surface protein of Lyme disease spirochetes
10. Variable major proteins of Borrelia hermsii
11. Lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibody
12. Molecular analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi
13. Characterization of Borrelia burgdorferi strains isolated from Ixodes pacificus ticks in California
14. Immunogenic integral membrane proteins of Borrelia burgdorferi are lipoproteins
15. Crossrective proteins of Borrelia burgdorferi
16. Clonal polymorphisms of outer membrane protein OspB of Borrelia burgdorferi
17. Susceptibility of the black lagged tick, Ixodes scapularis, to the Lyme disease spirochete, Borrelia burgdorferi
18. The variable antigens Vmp7 and Vmp21 of the relapsing fever bacterium Borrelia hermsii are structurally analogous to the VSG proteins of the African trypanosome
19. Antigens of Borrelia burgdorferi recognized during Lyme disease
20. The relapsing fevers: tick-spirochete specificity studies
21. Genetic analysis of Borrelia
22. Protection of mice against the Lyme disease agent by immunizing with recombinant OspA
23. Molecular analysis and expression of a Borrelia burgdorferi gene encoding a 22-kDa protein (pC) in Escherichia coli
24. Analysis of the Borrelia burgdorferi GeHo fla gene and antigenic characterization of its gene product
25. N-terminal amino acid sequence of the Borrelia burgdorferi flagellin
26. Immunoblot analysis of immunoglobulin G response to the Lyme disease agent (Borrelia burgdorferi) in experimentally and naturally exposed dogs
27. Comparison of immunoblotting and indirect enzyme-linked immunosorbent assay using different antigen preparations for diagnosing early Lyme disease
28. A single recombinant plasmid expressing two major outer surface proteins of the Lyme disease spirochete
29. Experimental infection of the hamster with B. burgdorferi
30. Borrelia burgdorferi sp nv etiologic agent of Lyme disease
31. Heterogeneity of outer membrane proteins of Borrelia burgdorferi: Comparison of osp Operons of three isolates of different geographic origins
32. Juxtaposition of expressed variable antigen genes with a conserved telomere in the bacterium Borrelia hermsii
33. The 83-kilodalton antigen of Borrelia burgdorferi which stimulates immunoglobulin M (IgM) and IgG responses in infected hosts is expressed by a chromosomal gene
34. Biochemical and immunological characterization of the surface proteins of Borrelia burgdorferi
35. Antigenic variation is associated with DNA rearrangements in a relapsing fever Borrelia sp.
36. Analysis of North American and European isolates of Borrelia burgdorferi with antiserum to a recombinant antigen
37. Expression of antigens from chromosomal and linear plasmid DNA of Borrelia coriaceae
38. Transposition of structural genes to an expression sequence on a linear plasmid causes antigenic variation in Borrelia hermsii
39. Two genomic species in Borrelia burgdorferi
40. Culture of Borrelia burgdorferi on six solid media
41. A specific and sensitive assay for the Lyme disease spirochete Borrelia burgdorferi using the polymerase chain reaction
42. DNA sequencing with chain-terminating inhibitors
43. Monoclonal antibodies specific for the outer surface protein (OspA) prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice
44. Demonstration of antigen-specific t cells and histopathological alterations in mice experimentally inoculated with Borrelia burgdorferi
45. Antigenic changes in B. burgdorferi as a result of in vitro cultivation
46. Changes in infectivity and plasmid profile of the Lyme disease spirochete, Borrelia burgdorferi, as a result of in vitro cultivation
47. Molecular and immunological analysis of a polymorphic periplasmic protein of Borrelia burgdorferi
48. Borrelia transfer by ticks during their life cycle
49. Antigenic variation of Borrelia hermsii
50. Outbreak of tick-borne relapsing fever in Spokane County, Washington
51. Characterization of an immunoreactive 93-kDa core protein of Borrelia burgdorferi with a human IgG monoclonal antibody
52. The Borrelia burgdorferi flagellum-associated 41-kilodalton antigen (flagellin): molecular clonin, expression, and amplification of the gene
53. Cloning and sequencing of the gene encoding the outer surface protein A (OspA) of a European Borrelia burgdorferi isolate
54. Antigenic heterogeneity of European Borrelia burgdorferi strains isolated from patients and ticks [letter]
55. Immunochemical and immunological analysis of European Borrelia burgdorferi strains
56. Antigenic variability of Borrelia burgdorferi
57. Immunochemische Analyse der Immunantwort bei Spätmanifestationen der Lyme Borreliose
58. Detection of IgM and IgG antibodies to Borrelia burgdorferi using different strains as antigen
59. Immunodominant proteins of Borrelia burgdorferi; implications for improving serodiagnosis of Lyme borreliosis
60. Taxonomy of Borrelia spp.
61. Genetic polymorphism of the gene encoding the outer surface protein A (OspA) of Borrelia burgdorferi