Enhanced prostaglandin biosynthesis in human gingival fibroblasts isolated from patients treated with phenytoin

Journal of Oral Pathology & Medicine

Volumn 21, Issue 6, 1992, Pages 251-255

  Modeer T ^a   Anduren, I ^a   Lerner, U H ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

Author keywords

gingival fibroblasts; Interleukin; phenytoin; prostaglandin E2; TNF

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ARACHIDONIC ACID; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; PHENYTOIN; PHOSPHOLIPASE A2; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ADVERSE DRUG REACTION; ARTICLE; CASE REPORT; DOSE RESPONSE; DRUG SENSITIVITY; EPILEPSY; FIBROBLAST CULTURE; GINGIVA HYPERPLASIA; HUMAN; HUMAN CELL; SCHOOL CHILD;

EID: 0026698784     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.1992.tb01005.x     Document Type: Article

References (24)

1. Phenytoin: Mechanisms of its anticonvulsant action
2. Chronic antiepileptic toxicity
3. Proteoglycans and glycosaminoglycans in phenytoin‐in‐duced gingival overgrowth
4. Synthesis of sulfated glycosaminoglycans by human gingival fibroblasts from phenyton‐induced gingival overgrowth in vitro
5. Potentiation of fibroblast DNA synthesis by a phenytoin‐induced mononuclear cell derived factor in vitro
6. Phenytoin induces interleukin‐1 production in vitro
7. Biology of interleukin‐1
8. An intcrleukin‐1 like factor stimulates bone resorption in vitro
9. Effects of cytokines on prostaglandin E and cAMP levels in human periodontal ligament fibroblasts in vitro
10. Interlcukin 1 stimulates its own receptor expression on human fibro‐blasls through the endogenous production of proslaglandin(s)
11. The effects of interleukin I on collagenolytic activity and prostaglandin‐E secretion by human periodontal‐ligamcnt and gingival fibroblast
12. Comparison of human interleukin‐1 p and its 163 171 peptide in bone resorption and the immune response
13. The effect of interleukin‐1β on hyaluronic acid synthesized by adult human gingival fibroblasts in vitro
14. The effect of interleukin 1P on proteoglycans synthesized by human gingival fibroblasts in vitro
15. Effect of fluoride on gingivitis and dental caries in a preventive program based on plaque control
16. The effect of the phenytoin metabolite p‐HPPH on proliferation of gingival fibroblasts in vitro
17. Stimulation of bone resorption in cultured mouse calvaria by Lysbradykinin (kallidin). a potential mediator of bone resorption linking ana‐phylaxis processes to rarefying osteitis
18. Bradykinin stimulates production of prostaglandin E; and prostacyclin in murine osteoblasts
19. 2+ level in human gingival fibroblasts
20. Fibroblast heterogeneity and prostaglandin regulation of subpopulations
21. 2 in cultured lung fibroblasts
22. Modulation of the effects of interleukin‐1 on glycosaminoglycan synthesis by the urine‐derived interleukin‐1 inhibitor, but not by interleu‐kin‐6