Synthesis of in vivo potent antimalarial 1,2,4-trioxanes

Bioorganic and Medicinal Chemistry Letters

Volumn 2, Issue 5, 1992, Pages 497-500

  Singh, Chandan ^a   Misra, Dharmendra ^a   Saxena, Gunjan ^a   Chandra, Subhash ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 TRIOXANE DERIVATIVE; ANTIMALARIAL AGENT;

ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STABILITY; DRUG SYNTHESIS; INTRAPERITONEAL DRUG ADMINISTRATION; MALARIA; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; TEMPERATURE;

EID: 0026697610     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)80177-8     Document Type: Article

References (30)

1. Current trends in new drug research in the People's Republic of China
2. Synthesis and reaction of 1,2,4-trioxanes
3. Synthesis of 1,2,4-trioxanes via intramolecular oxymercuriation
4. Perhydrolysis of epoxides
5. A novel tricyclic peroxide from the photochemical oxidation of plastoquinone-1 [2,3-dimethyl-5-(3-methylbut-2-enyl)-1,4-benzoquinone]
6. Laser-induced formation of 1,2,4-trioxans: the trapping of oxetan precursors with molecular oxygen
7. Exothermic cyclic peroxide reactions. Decomposition of a 1,2,4-trioxane
8. Synthesis and reactions of 5-arylamino-1,2,4-trioxans
9. Photo-oxygenation of alkenoyl-1,4-quinones by atmospheric oxygen. Formation of stable cyclic peroxides