The Discovery of (2S,3S)-cis-2-(Diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]- octan-3-amine as a Novel, Nonpeptide Substance P Antagonist

Journal of Medicinal Chemistry

Volumn 35, Issue 14, 1992, Pages 2591-2600

  Lowe, John A ^a   Drozda, Susan E ^a   Snider, R Michael ^a   Longo, Kelly P ^a   Zorn, Stevin H ^a   Morrine, J Morrine ^a   Jackson, Elisa R ^a   McLean, Stafford ^a   Bryce, Dianne K ^a   Bordner, J Bordner ^a   Nagahisa, Atsushi ^a   Kanai, Yoshihito ^a   Suga, Osamu ^a   Tsuchiya, Megumi ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; SUBSTANCE P ANTAGONIST; SUBSTANCE P RECEPTOR;

ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG SYNTHESIS; EXTRAVASATION; GUINEA PIG; NONHUMAN; PLASMA; PRIORITY JOURNAL; SALIVATION; STRUCTURE ACTIVITY RELATION;

EID: 0026695818     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00092a009     Document Type: Article

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