DAPI (4', 6-Diamidino-2-Phenylindóle) Binds Differently to DNA and RNA: Minor-Groove Binding at AT Sites and Intercalation at AU Sites

Biochemistry

Volumn 31, Issue 12, 1992, Pages 3103-3112

  Tanious, Farial A ^a   Veal, James M ^a   Buczak, Henryk ^a   Ratmeyer, Lynda S ^a   Wilson, W David ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; ADENINE; DISTAMYCIN A; DNA; INTERCALATING AGENT; MEPACRINE; PROPIDIUM IODIDE; RNA; THYMINE; URACIL;

ABSORPTION SPECTROSCOPY; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; DNA BINDING; DNA SEQUENCE; DRUG BINDING SITE; DRUG DESIGN; DRUG PROTEIN BINDING; PRIORITY JOURNAL; PROTEIN STABILITY; RNA CONFORMATION; RNA SEQUENCE;

ADENINE NUCLEOTIDES; BINDING SITES; COMPARATIVE STUDY; DNA; FLUORESCENT DYES; INDOLES; INTERCALATING AGENTS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROPIDIUM; RNA; SALTS; SPECTROMETRY, FLUORESCENCE; SUPPORT, U.S. GOV'T, P.H.S.; URACIL NUCLEOTIDES; VISCOSITY;

EID: 0026690994     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00127a010     Document Type: Article

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