Determinants of metabolite disposition

Annual Review of Pharmacology and Toxicology

Volumn 32, Issue , 1992, Pages 623-669

  Pang, K Sandy ^a   Xu, Xin ^a,b   St Pierre, Marie V ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

^c TUFTS UNIVERSITY   (United States)

Author keywords

clearances (intrinsic, transmembrane, hepatic, renal, unbound); drug and metabolite (primary, secondary, tertiary) extraction ratios; liver, intestine and kidney metabolism and excretion; metabolite sequential metabolism; physiological variables (organ blood flow, protein binding, enzymic heterogeneity)

Indexed keywords

DRUG METABOLITE; ENALAPRIL; ENALAPRILAT; GENTISAMIDE; HARMOL; LIDOCAINE; PARACETAMOL; PHENACETIN; SALICYLAMIDE; UMBELLIFERONE;

DRUG CLEARANCE; DRUG DISPOSITION; DRUG METABOLISM; HUMAN; INTESTINE; KIDNEY; LIVER; LIVER BLOOD FLOW; LIVER PERFUSION; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; REVIEW;

EID: 0026690639     PISSN: 00664251     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.pa.32.040192.003203     Document Type: Review

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