Relevance of glutamine metabolism to tumor cell growth

Molecular and Cellular Biochemistry

Volumn 113, Issue 1, 1992, Pages 1-15

  Medina, Miguel Angel ^a   Sánchez Jiménez, Francisca ^a   Márquez, Javier ^a   Rodríguez Quesada, Ana ^a   de Castro Núñez, Ignacio ^a  

^a UNIVERSITY OF MÁLAGA   (Spain)

Author keywords

glutaminase; glutamine; glutamine analogues; glutamine transport; tumor cells

Indexed keywords

6 DIAZO 5 OXONORLEUCINE; ACIVICIN; ASPARAGINASE; AZASERINE; GLUCOSE; GLUTAMINASE; GLUTAMINE; GLUTAMINE DERIVATIVE;

AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ANTINEOPLASTIC ACTIVITY; CANCER CHEMOTHERAPY; COMPETITIVE INHIBITION; ENERGY RESOURCE; ENZYME ACTIVITY; GLUCOSE METABOLISM; HUMAN; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TUMOR GROWTH;

ANIMAL; BIOLOGICAL TRANSPORT, ACTIVE; GLUTAMINE; HUMAN; MITOCHONDRIA; NEOPLASMS; SUPPORT, NON-U.S. GOV'T;

EID: 0026689816     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/BF00230880     Document Type: Article

References (176)

1. Glutaminolysis and glycolysis interactions in proliferant cells
2. Amino acids and glucose utilization by different metabolic pathways in ascites-tumour cells
3. Ketone body, glucose, lactic acid and amino acid utilization by tumors in vivo in fasted rats
4. Glycolysis and glutaminolysis in perifused Ehrlich ascites tumour cells
5. The utilization of unsterified palmitate by Ehrlich ascites tumor cells
6. Competition for host essential and nonessential fatty acids in Ehrlich ascites carcinoma in mice
7. Fatty acid oxidation to H2O by Ehrlich ascites carcinoma in mice
8. Nitrogen movement between host and tumor in mice inoculated with Ehrlich ascites tumor cells
9. Malate-citrate cycle during glycolysis and glutaminolysis in Ehrlich ascites tumor cells
10. Effect of palmitate, acetate and glucose on glutamine metabolism in Ehrlich ascites tumor cells
11. Some aspects of nitrogen and energy metabolism in cancerous subjects
12. The metabolic environment of cancer
13. A quantitative approach to metabolic control
14. Glucagon and epinephrine effect on blood-glucose levels in rats carrying Yoshida solid sarcoma and Walker-256 carcinosarcoma
15. Altered amino-acid kinetics in rats with progressive tumor growth
16. Amino acid metabolism in man
17. Nitrogen metabolism in tumor bearing mice
18. The pathways of glutamate and glutamine oxidation by tumor cell mitochondria
19. Tumor causes changes in host protein synthesis under different dietary situations
20. On the multiform relationships between the tumor and the host
21. Metabolic alterations in cancer I
22. Metabolic alterations in cancer II
23. Cancer, a disease of individuals. Relationship between host and tumor
24. Nutrition and cancer: physiological interrelationships
25. Catalytic mechanism of glutamine synthetase; overview of glutamine metabolism
26. Glutamine metabolism in the animal body
27. Glutamine: a major energy source for cultured mammalian cells
28. Enzymology of glutamine
29. Mitochondrial metabolism of glutamine and glutamate and its physiological significance
30. Glutaminolysis in animal cells
31. Glycolysis, glutaminolysis and cell proliferation
32. Regulation of renal ammoniagenesis. Subcellular localization of rat kidney glutaminase isoenzymes
33. Enzymes of cerebral glutamine metabolism
34. Glutamine metabolism in skeletal muscle from the broiler chick (Gallus domesticus) and the laboratory rat (Rattus norvegicus)
35. The possible role of glutamine substrate cycles in skeletal muscle
36. Does glutamine regulate skeletal muscle protein turnover?
37. Factors regulating amino acid release from extrasplanchnic tissues in the rat. Interactions of alanine and glutamine
38. Glutamine metabolism in the rat
39. Metabolism of glutamine, glutamate and aspartate
40. Enterohepatic aspects of glutamine metabolism
41. Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver
42. Cellular distribution and regulation of glutamine synthetase in liver
43. Localization and some properties of phosphate-dependent glutaminase in disrupted liver mitochondria
44. Bioenergetics of tumor cells. Glutamine metabolism in tumor cell mitochondria
45. Hepatic glutamine and ammonia metabolism. Nitrogen and redox balance and the intercellular glutamine cycle
46. Distribution of hepatic glutaminase activity and mRNA in perivenous and periportal rat hepatocytes
47. Hepatic glutamine metabolism under the influence of the portal ammonia concentration in the perfused rat liver
48. Regulation of flux through glutaminase and glutamine synthetase in isolated perfused rat liver
49. Hepatic glutaminase flux regulation of glutamine homeostasis. Studies in vivo
50. Amino acid extrusion and NH3 metabolism by the human kidney during the prolonged administration of NH4Cl
51. Glutamine synthetase and glutamyltransferase in the kidney of man, dog, and rat
52. Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency
53. Arteriovenous differences for amino acids and lactate across kidneys of normal and acidotic rats
54. Species differences in renal glutamine synthesis in vivo
55. Role of fatty acids in simultaneous regulation of flux through glutaminase and glutamine synthetase in rat kidney cortex
56. Measurements of the turnover rate of glutamine in normal and acidotic rats
57. Amino acid neurotransmitters
58. The metabolic fate of 13N-labeled ammonia in rat brain
59. Cerebral glutamine synthetase
60. Enzymes of cerebral glutamine metabolism
61. Cerebral glutamine/glutamate interrelationships and metabolis compartmentation
62. Glutamine metabolism in brain
63. Glutamine utilization by the small intestine
64. Uptake and metabolism of plasma glutamine by the small intestine
65. Metabolism of vascular and luminal glutamine by intestinal mucosa in vivo
66. Nutritional abnormalities in cancer
67. The enzymic pattern of neoplastic tissue
68. Alanine as a gluconeogenic carrier
69. Contribution by host tissues to circulating glutamine in mice inoculated with Ehrlich ascites tumor cells
70. The effects of tumour necrosis factor-alpha (cachectin) and tumour growth on hepatic amino acid utilization in the rat
71. Reduction of tumor growth following treatment with a glutamine antimetabolite
72. The effect of an Ehrlich ascites tumour on the rate of protein synthesis in muscle and liver of the host
73. Protein metabolism in tumour-bearing mouse
74. Comparative biochemistry of hepatomas. V
75. Mouse liver free amino acids during the development of Ehrlich ascites tumour
76. The energy state of tumorbearing rats
77. Early development of protein metabolic perturbations in the liver and skeletal muscle of tumour-bearing rats
78. Early systemic effects on the hepatic mitochondria of tumour bearing mice
79. Altered ornithine metabolism in tumor-bearing mice
80. The effect of metabolic acidosis on the synthesis and turnover of rat renal phosphatedependent glutaminase
81. Kinetics of cell proliferation and polyamine synthesis during Ehrlich ascites tumor growth
82. Stoffwechseluntersuchungen bei Krebskranken
83. Malignancy and tissue metabolism
84. Proteins of amino acid biosynthesis from labeled glucose
85. Metabolic patterns for glucose-1-C14 in tissues of tumor-bearing rats
86. Electrogenic amino acid transport
87. Amino acid transport in tumor cells
88. Role of amino acid transport and countertransport in nutrition and metabolism
89. Characteristics of an amino acid transport system in rat liver for glutamine, asparagine, histidine, and closely related analogs
90. The use of the perfused rat hindlimb for studies of sugar and amino acid transport
91. L-Glutamine transport in native vesicles isolated from Ehrlich ascites tumor cell membranes
92. Distinct mediating systems for the transport of neutral amino acids by the Ehrlich cell
93. A distinct Na+-requir-ing transport system for alanine, serine, cysteine, and similar amino acids
94. Evidence for an essential suithydryl group at the substrate binding side of the A system transport of Ehrlich cell plasma membranes
95. Uptake of glutamine antimetabolites 6-diazo-5-oxo-L-norleucine (DON) and Acivicin in sensitive and resistent tumor cell lines
96. Effect of Acivicin on glutamine transport by rat renal brush border membrane vesicles
97. Substrate-specificity of glutamine transporters in membrane vesicles from rat liver and skeletal muscle investigated using amino acid analogues
98. Simple and effective purification of a Na+-dependent amino acid transport system from Ehrlich ascites cell plasma membranes
99. Overview on mitochondrial metabolite transport systems
100. Direct methods for measuring metabolite transport and distribution in mitochondria
101. Methodology for transport studies. Graphical and computer curve fitting methods for glutamate and aspartate efflux kinetics
102. Metabolic transport in mitochondria
103. Condition for activity of glutaminase in kidney mitochondria
104. The transport and metabolism of glutamine by kidney cortex mitochondria from normal and acidotic rats
105. Glutamine transport and metabolism by mitochondria from dog renal cortex
106. Glutamine transport by mitochondria isolated from normal and acidotic rats
107. Importance of the flux of phosphate across the inner membrane of kidney mitochondria for the activation of glutaminase and the transport of glutamine
108. The inhibitory effect of sulfhydryl reagents on the transport and hydrolysis of glutamine in rat liver mitochondria
109. Renal mitochondrial glutamine transport and metabolism. Studies with rapid-mixing, rapid filtration technique
110. Kinetics of glutamine efflux from liver mitochondria loaded with the 14C-labeled substrate
111. Glutamine transport in submitochondrial particles
112. Molecular targets of anti-glutamine therapy with Acivicin in cancer cells
113. Multi-enzyme-targeted chemotherapy by Acivicin and actinomycin
114. Neoplastic transformation of newborn rat astrocytes in culture
115. Glutamine synthetase and glutaminase activities in various hepatoma cells
116. A comparative study of glutaminase isozymes in rat tissues
117. Glutamine and glucose metabolism during thymocyte proliferation
118. Glutaminase of the human malignant cell, strain HeLa
119. Distribution of glutaminase isoenzymes in kidney cells
120. Purification of phosphatedependent glutaminase from isolated mitochondria of Ehrlich ascites-tumour cells
121. Cellular compartmentation of Ehrlich ascites tumor cells
122. Inorganic phosphate and energy charge compartmentation in Ehrlich ascites tumour cells in the pres ence of glucose and/or glutamine
123. 31P-NMR studies of glucose and glutamine metabolism in cultured mammalian cells
124. Purification, kinetic behavior, and regulation of NAD(P)+ malic enzyme of tumor mitochondria
125. The function of redox shuttles during aerobic glycolysis in two strains of Ehrlich ascites tumor cells
126. Glutamine metabolism in Ehrlich ascites carcinoma cells
127. Glutamine and glucose as energy substrates for Ehrlich ascites tumour cells
128. L-Glutamine: a major substrate for tumor cells in vivo?
129. Respiration of mitochondria isolated from differentiated and undifferentiated HT29 colon cancer cells in the presence of various substrates and ADP generating systems
130. Evidence that glutamate, not sugar, is the major energy source for cultured HeLa cells
131. Measurement of ‘in situ’ mitochondrial membrane potential in Ehrlich ascites tumor cells during aerobic glycolysis
132. Evidence of an intracellular dissipative structure
133. Metabolism and action of amino acid analog anti-cancer agents
134. Efficacy of 6-diazo-5-oxo-L-norleucine and N-N-gamma-glutamyl-6-diazo-5-oxo-norleucinyl-6-diazo-5-oxo-norleucine against experimental tumors in conventional and nude mice
135. The rediscovery of DON
136. Phase I and pharmacokinetic studies of DON
137. Acivicin. An antitumor antibiotic
138. Effects of acivicin and dichloroallyl lawsone upon pyrimidine biosynthesis in mouse L1210 leukemia cells
139. Enzyme targets of antiglutamine agents in cancer chemotherapy
140. Inactivation by acivicin of carbamoyl-phosphate synthetase II of human colon carcinoma
141. Control of enzymic programs and nucleotide pattern in cancer cells by acivicin and tiazofurin
142. Biochemical pharmacology of acivicin in rat hepatoma cells
143. Effect of L-glutamine antagonists on 5-phosphoribosyl 1-pyrophosphate levels in P388 leukemia and in murine colon adenocarcinomas in vivo
144. Glutaminases and gamma-glutamil transferases
145. Reduction of tumor growth following treatment with a glutamine antimetabolite
146. Enhancement of the sensitivity of human colon cancer cells to growth inhibition by acivicin achieved through inhibition of nucleic acid precursor salvage by dipyridamole
147. Glutamine-enriched diets support muscle glutamine metabolism without stimulating tumor growth
148. Response of tumor and host to hyperalimentation and antiglutamine treatments
149. Insulin and acivicin improve host nutrition and prevent tumor growth during total parenteral nutrition
150. Prevention of central nervous system toxicity of the antitumor antibiotic acivicin by concomitant infusion of an amino acid mixture
151. Effects of the combination of acivicin and cis-diammine-dichloroplatinum (II) on thymidylate synthesis of A549 lung cancer cells
152. In vitro and in vivo anti-tumor activity of L-glutamic acid gamma-monohydroxamate against L1210 leukemia and B16 melanoma
153. Phase II trial of 6-diazo-5-oxo-L-norleucine versus aclacinomycin-A in ad vanced sarcomas and mesotheliomas
154. Phase II study of acivicin in non-small cell lung cancer: a National Cancer Institute of Canada Study
155. Phase II trial of acivicin in patients with advanced colorectal carcinoma
156. Phase II trial of acivicin in patients with advanced epithelial ovarian carcinoma
157. Interaction of azaserine and raw soya flour on the rat pancreas
158. Growth of pancreatic foci and development of pancreatic cancer with a single dose of azaserine in the rat
159. Inhibition of tumor cell glutamine uptake by isolated neutrophils
160. Nitrogen utilization in mice bearing Ehrlich ascites tumor treated with Acinetobacter glutaminaseasparaginase
161. Amino acid utilization and urine protein excretion in children treated with succinylated Acinetobacter glutaminase-asparaginase
162. Enhancement of antitumor activity of glutamine antagonists 6-diazo-5-oxo-L-norleucine and Acivicin in cell culture by glutaminase-asparaginase
163. Asparaginase as a drug for treatment of acute lymphoblastic leukaemia
164. Inactivation of microbial glutamin-(aparagin-)ase by azaserine and 6-diazo-5-oxoL-norleucine