NK-1, but not NK-2, tachykinin receptors mediate plasma extravasation induced by antidromic C-fiber stimulation in rat hindpaw: Demonstrated with the NK-1 antagonist CP-96,345 and the NK-2 antagonist Men 10207

Neuroscience Letters

Volumn 139, Issue 2, 1992, Pages 249-252

  Xu, X J ^a   Dalsgaard, C J ^b   Maggi, C A ^c   Wiesenfeld Hallin, Z ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c Menarini Ricerche SpA   (Italy)

Author keywords

Neurogenic inflammation; Neurokinin A; Substance P; Tachykinin; Unmyelinated afferent

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; NEUROKININ A [4-10][5 TYROSINE 6,8,9 DEXTRO TRYPTOPHAN 10 ARGININE]; RECEPTOR SUBTYPE; TACHYKININ RECEPTOR; TACHYKININ RECEPTOR ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EXTRAVASATION; INFLAMMATION; INTRADERMAL DRUG ADMINISTRATION; MALE; NONHUMAN; PAW; PRIORITY JOURNAL; RAT; SENSORY NERVE;

ANIMALS; BIPHENYL COMPOUNDS; ELECTRIC STIMULATION; FEMALE; FOOT; NERVE FIBERS; NEUROKININ A; PEPTIDE FRAGMENTS; RATS; RATS, INBRED STRAINS; RECEPTORS, NEUROTRANSMITTER; RECEPTORS, TACHYKININ;

EID: 0026688898     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(92)90564-N     Document Type: Article

References (19)

1. Effects of tachykinins and selective receptor agonists on vascular permeability in the rat lower urinary tract: evidence for the involvement of NK-1 receptors
2. NK-1 receptor mediation of neurogenic plasma extravasation in rat skin
3. Plasma extravasation induced by mammalian tachykinins in rat skin: influence of anesthetic agents and an acetylcholine antagonist
4. Neurokinin A-like immunoreactivity in rat primary sensory neurons; coexistence with substance P
5. Substance P-induced cutaneous plasma extravasation in rats in mediated by NK-1 tachykinin receptors
6. Potentiation of tachykinin-induced plasma extravasation by calcitonin gene-related peptide
7. Spantide II, a novel tachykinin antagonist having high potency and low histamine-releasing effect
8. Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides
9. Capillary permeability induced by intravenous neurokinins: receptor characterization and mechanism of action
10. Role of NK-1 tachykinin receptors in thermonociception: effect of (±)-CP-96,345, a non-peptide substance P antagonist, on the hot plate test in mice
11. Competitive antagonists discriminate between NK-2 tachykinin receptor subtypes
12. Activity and distribution of binding sites in brain of a non-peptide substance P (NK-1) receptor antagonist
13. Novel SP antagonist, CP-96,345, blocks responses of cat spinal dorsal horn neurons to noxious cutaneous stimulation and to substance-P
14. A potent non-peptide antagonist of the substance P (NK-1) receptor
15. Partially overlapping territories of nerves to hindlimb foot skin demonstrated by plasma extravasation to antidromic C-fiber stimulation in the rat
16. Spantide II, a novel tachykinin antagonist, and galanin inhibit plasma extravasation induced by antidromic C-fiber stimulation in rat hindpaw
17. On the role of NK-2 tachykinin receptor in the mediation of spinal reflex excitability in the rat
18. On the role of NK-1 and NK-2 tachykinin receptors in mediation of spinal cord reflex excitability